PPARα and GR differentially down-regulate the expression of nuclear factor-κB-responsive genes in vascular endothelial cells

Endocrinology

Volumn 142, Issue 8, 2001, Pages 3332-3339

  Xu, Xin ^a   Otsuki, Michio ^a   Saito, Hiroshi ^a   Sumitani, Satoru ^a   Yamamoto, Hiroyasu ^a   Asanuma, Nobuyuki ^a   Kouhara, Haruhiko ^a   Kasayama, Soji ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CELL NUCLEUS RECEPTOR; CYTOKINE; DEXAMETHASONE; FENOFIBRATE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; ANTILIPEMIC AGENT; CELL RECEPTOR; TRANSCRIPTION FACTOR;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATTLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA RESPONSIVE ELEMENT; DOWN REGULATION; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; VASCULAR ENDOTHELIUM; BIOSYNTHESIS; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANTILIPEMIC AGENTS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CELLS, CULTURED; DEXAMETHASONE; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-6; NF-KAPPA B; PROCETOFEN; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 85047684089     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.8.8340     Document Type: Article

References (56)

1. New roles for the endothelium in inflammation and immunity
2. The complexity of endothelial cells. A review
3. Endothelial-leukocyte adhesion molecules in human disease
4. Regulation of tumor necrosis factor α transcription in macrophages: Involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB
5. Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements
6. Glucocorticoid effects on the production and actions of immune cytokines
7. Sex hormones and dexamethasone modulate interleukin-5 gene expression in T lymphocytes
8. Glucocorticoids inhibit the production of IL6 from monocytes, endothelial cells and fibroblasts
9. Inhibition of interleukin-8 expression by dexamethasone in human cultured airway epithelial cells
10. A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1
11. Glucocorticoids inhibit E-selectin expression by targeting NF-κB and not ATF/ c-Jun
12. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms
13. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
14. Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
15. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
16. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor
17. Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids
18. Glucocorticoid-mediated repression of NF-κB activity in endothelial cells does not involve induction of IκBα synthesis
19. IκBα-independent downregulation of NF-κB activity by glucocorticoid receptor
20. Effects of 17β-estradiol on cytokine-induced endothelial cell adhesion molecule expression
21. Selective estrogen receptor modulators: Different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells
22. Progesterone, but not medroxyprogesterone, inhibits vascular cell adhesion molecule-1 expression in human vascular endothelial cells
23. Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule-1 by cultured dermal microvascular endothelial cells
24. PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
25. NF-κB and Rel: Participants in a multiform transcriptional regulatory system
26. NF-κB: A lesson in family values
27. Involvement of a NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines
28. Functional analysis of the human vascular cell adhesion molecule 1 promoter
29. Functional domains of the human glucocorticoid receptor
30. Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells
31. Advanced glycation end-products stimulate interleukin-6 production by human bone-derived cells
32. Glucocorticoid-mediated suppression of the promoter activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells
33. Expression of peroxisome proliferator-activated receptor α (PPARα) in primary cultures of human vascular endothelial cells
34. Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo
35. Expression and function of PPARγ in rat and human vascular smooth muscle cells
36. PPARγ activation in human endothelial cells increases plasminogen activator type-1 expression: PPARγ as a potential mediator in vascular disease
37. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
38. IL-6 and NF-IL6 in acute-phase response and viral infection
39. Interleukin-6 stimulates c-myc expression and proliferation of cultured vascular smooth muscle cells
40. Interleukin 6 gene transcripts are expressed in atherosclerotic legions of genetically hyperlipidemic rabbits
41. Interleukin 6 gene transcripts are expressed in human atherosclerotic legions
42. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA4/fibronectin binding site
43. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
44. Soluble forms of vascular adhesion molecules, E-selection, ICAM-1, and VCAM-I: Pathological significance
45. Circulating vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic NIDDM patients
46. Relationship between circulating vascular cell adhesion molecule-1 and microvascular complications in type 2 diabetes mellitus
47. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms
48. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids
49. Immuno-suppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
50. Repression of the interleukin-6 promoter by estrogen recepter is mediated by NF-κB and C/EBPβ
51. Negative interaction between the RelA (p65) subunit of NF-κB and the progesterone receptor
52. Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
53. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
54. Nuclear integration of glucocorticoid receptor and nuclear factor-κB signalling by CREB-binding protein and steroid receptor coactivator-1
55. CBP (CREB binding protein) integrates NF-κB (nuclear factor-κB) and glucocorticoid receptor physical interactions and antagonism
56. Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell