The gm2-1 ganglioside islet autoantigen in insulin-dependent diabetes mellitus is expressed in secretory granules and is notβ -cell specific

Endocrinology

Volumn 139, Issue 1, 1998, Pages 316-319

  Dotta, Francesco ^a   Previti, Marcello ^a,c   Neerman Arbez, Marguerite ^e   Dionisi, Sabrina ^a   Cucinotta, Domenico ^c   Lenti, Luisa ^b   Di Mario, Umberto ^d   Halban, Philippe A ^e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

^d UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^e UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001348950     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo.139.1.5708     Document Type: Article

References (36)

1. Hakomori SI 1981 Glycosphingolipids in cellular interaction, differentiation and oncogenesis. Annu Rev Biochem 50:733-764
2. Castano L, Eisenbarth GS1990 Typel diabetes: a chronic autoimmune disease of human, mouse and rat. Annu Rev Immunol 8:647-679
3. Atkinson M A, MacLaren NK1993 Islet cell autoantigens in insulin dependent diabetes. J Clin Invest 92:1608
4. Gianani R, Pugliese A, Bonner Weir S, Schiffrin AJ, Soeldner JS, Erlich H, Awdeh Z, Alpert CA, Jackson RA, Eisenbarth GS 1992 Prognostically significant heterogeneity of cytoplasmic islet cell autoantibodies in relatives of patients with type 1 diabetes. Diabetes 41:347-353
5. Genovese S, Bonifacio E, McNally JM, Dean BM, Wagner R, Bosi E, Gale EAM, Bottazzo GF 1992 Distinct cytoploasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35:385-389
6. Atkinson MA, Kaufman DL, Campbell L, Tobin AJ, MacLaren NK 1993 Islet cell cytoplasmic antibodies reactivity to glutamate decarboxylase in insulin dependent diabetes. J Clin Invest 91:350-356
7. Colman PG, Nayak RC, Campbell IL, Eisenbarth GS 1988 Binding of cytoplasmic islet cell antibodies is blocked by human pancreatic glycolipid extract. Diabetes 37:645-652
8. Dotta F, Colman PG, Lombardi D, Scharp DW, Andreani D, Pontieri GM, Di Mario U, Lenti L, Eisenbarth GS, Nayak RC 1989 Ganglioside expression in human pancreatic islets. Diabetes 38:1478-1483
9. Dotta F, Tiberti C, Previti M, Anastasi E, Andreani D, Lenti L, Pontieri GM, Gianani R, Appel MC, Eisenbarth GS, Di Mario U 1993 Rat pancreatic ganglioside expression: differences between a model of autoimmune islet 0 cell destruction and a normal strain. Clin Immunol Immunopathol 66:143-149
10. Dotta F, Peterson LB, Previti M, Metzger J, Tiberti C, Anastasi E, Zoppitelli P, Wicker LS, Di Mario U 1992 Pancreatic islet ganglioside expression in non obese diabetic mice: comparison with C57BL/10 mice and changes after autoimmune β cell destruction. Endocrinology 130:37-42
11. Dotta F, Previti M, Lenti L, Dionisi S, Casetta B, D'Erme M, Eisenbarth GS, Di Mario U 1995 GM2-1 pancreatic islet ganglioside: identification and characterization of a novel islet-specific molecule. Diabetologia 38:1117-1121
12. Dotta F, Gianani R, Previti M, Lenti L, Dionisi S, D'Erme M, Eisenbarth GS, Di Mario U 1996 Autoimmunity to the GM2-1 islet ganglioside before and at the onset of type 1 diabetes. Diabetes 45:1193-1196
13. Appel MC, Dotta F, O'Neill JJ, Eisenbarth GS 1989 Beta cell activity regulates the expression of islet antigenic determinants. Diabetologia 32:461 (Abstract)
14. Roullier DG, Cirulli V, Halban PA 1990 Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell types. Exp Cell Res 191:305-312
15. Ullrich S, Wollheim C 1989 Characterization of a2-adrenoreceptors in a plas-ma-membrane enriched fraction from the insulin-secreting cell-line RINm5F. Acta Endocrinol (Copenh) 121:525-532
16. Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB 1992 Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178
17. Felsenfeld DP, Sweadner KJ 1988 Fine specificity mapping and topography of an isozyme-specific epitope of the Na, K-ATPase catalytic subunit. J Biol Chem 263:10932-10942
18. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ 1965 Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375-1384
19. Svennerholm L, Fredman P 1980 A procedure for quantitative isolation of brain gangliosides. Biochim Biophys Acta 617:97-109
20. Williams MA, McCluer RH 1980 The use of Sep-Pak C18 cartridges during the isolation of gangliosides. J Neurochem 35:266-269
21. Svennerholm L 1963 Chromatographic separation of human brain gangliosides. J Neurochem 10:613-623
22. Jourdian GW, Dean L, Roseman S1971 The sialic acids: a periodate-resorcinol method for the quantitative estimation of free sialic acids and their glycosides. J Biol Chem 246:430-435
23. Neerman-Arbez M, Sizonenko SV, Halban PA 1993 Slow cleavage at the proinsulin B-chain/connecting peptide junction associated with low levels of endoprotease PCIβ in transformed β cells. J Biol Chem 268:16098-16100
24. Neerman-Arbez M, Halban PA 1993 Novel, non-crinophagic degradation of connecting peptide in transformed pancreatic beta cells. J Biol Chem 16248-16252
25. Van Echten G, Sandhoff K 1993 Ganglioside metabolism. Enzymology, topology and regulation. J Biol Chem 268:5341-5344
26. Halban PA, Inninger JC 1994 Sorting and processing of secretory proteins. Biochem J 299:1-18
27. Seethaler G, Huttner W1991 Secretory protein sorting, processing and granule biogenesis. Trends Cell Biol 1:35-36
28. Pryer NK, Wuestehube LJ, Schekman R 1992 Vesicle-mediated protein sorting. Annu Rev Biochem 61:471-516
29. Orci L, Ravazzola M, Amherdt M, Louvard D, Perrelet A 1985 Clathrin-immunoreactive sites in the Golgi apparatus are concentrated at the trans pole in polypeptide hormone-secreting cells. Proc Natl Acad Sci USA 82:5385-5389
30. Griffiths G, Simons K 1986 The trans Golgi network: sorting at the exit site of the Golgi complex. Science 234:438-443
31. Palmer JP, Asplin CM, Clemons P, Lyon K, Tatpati O, Raghu P, Paquette TL 1983 Insulin autoantibodies in insulin dependent diabetes before insulin treatment. Science 222:1337-1339
32. Castano L, Russo E, Zhou L, Lipes MA, Eisenbarth GS1991 Identification and cloning of a granule autoantigen (carboxypeptidase H) associated with type 1 diabetes. J Clin Endocrinol Metab 73:1197-1201
33. Roep BO, Ardern SD, DeVries RRP, Hutton JC 1990 T-Cell clones from a type 1 diabetes patient respond to insulin secretory granules proteins. Nature 345:632-634
34. Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rae PMM 1994 Islet antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152:3183-3188
35. Hawkes CJ, Wasmeier C, Christie MR, Hutton JC 1996 Identification of the 37kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to LA-2. Diabetes 45:1187-1192
36. Aanstoot HJ, Kang S, Kim J, Lindsay L, Roll U, Knip M, Atkinson MA, Mose-Larsen P, Fey S, Ludvigsson J, Landin M, Bruining J, MacLaren N, Akerblom HK, Baekkeskov S 1996 Identification and characterization of Glima 38, a glycosilated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes. J Clin Invest 97:2772-2783