Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid-producing plants of Ethiopia

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 6, 2009, Pages 801-808

  Nibret, Endalkachew ^a   Sporer, Frank ^a   Asres, Kaleab ^b   Wink, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ADDIS ABABA UNIVERSITY   (Ethiopia)

Author keywords

Ethiopia; HL 60 cells; In vitro; Medicinal plants; Pyrrolizidine alkaloids; Trypanosoma brucei brucei

Indexed keywords

CROTALARIA PHILLIPSIAE EXTRACT; DICHLOROMETHANE; PLANT EXTRACT; PYRROLIZIDINE ALKALOID; SENECIONINE; SOLANECIO ANGULATUS EXTRACT; UNCLASSIFIED DRUG; ZINC; ANTINEOPLASTIC AGENT; ANTITRYPANOSOMAL AGENT;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CROTALARIA PHILLIPSIAE; CYTOTOXICITY; DRUG SELECTIVITY; ETHIOPIA; FLOW; HUMAN; IC 50; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; SOLANECIO ANGULATUS; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS; ANIMAL; ASTERACEAE; CELL STRAIN HL 60; CHEMISTRY; CROTALARIA; DRUG EFFECT; FLOWER; ISOLATION AND PURIFICATION; PLANT STEM;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ASTERACEAE; CELL PROLIFERATION; CROTALARIA; ETHIOPIA; FLOWERS; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; PLANT EXTRACTS; PLANT STEMS; PYRROLIZIDINE ALKALOIDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 85047681738     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.06.0014     Document Type: Article

References (40)

1. Donelson JE. Antigenic variation and the African trypanosome genome. Acta Trop 2003; 85(30): 391-404.
2. Ford J et al. Trypanosomiasis Control Programme for Ethiopia. Report to the Ethiopian government of the British technical assistance team appointed to determine a programme for Tsetse fly and trypanosomiasis control and subsequent land use in southwestern Ethiopia. London: Ministry of Overseas Development of the British Government. 1976.
3. Geerts S et al. African bovine trypanosomiasis: the problem of drug resistance. Trends Parasitol 2001; 17(1): 25-28.
4. Matovu E et al. Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle. Microbes Infect 2001; 3: 763-770.
5. Asres K et al. Patterns of pyrrolizidine alkaloids in 12 Ethiopian Crotalaria species. Biochem Syst Ecol 2004; 32: 915-930.
6. Asres K et al. Identification and quantification of hepatotoxic pyrrolizidine alkaloids in the Ethiopian medicinal plant Solanecio gigas (Asteraceae). Pharmazie 2007; 69: 709-713.
7. Asres K et al. Occurrence of pyrrolizidine alkaloids in three Ethiopian Solanecio species. Biochem Syst Ecol 2008; 36: 399-407.
8. Mattocks AR. Hydrolysis and hepatoxicity of retronecine diesters. Toxicol Lett 1982; 14: 111-116.
9. Couet CE et al. Metabolic activation of pyrrolizidine alkaloids by human, rat and avocado microsomes. Toxicon 1996; 34(9): 1058-1061.
10. Fu PP et al. Pyrrolizidine alkaloids: genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug Metab Rev 2004; 36(1): 1-55.
11. Lien EJ, Li WY. Anticancer Chinese drugs: structure-activity relationships. In: Chang HM et al. eds. Advances in Chinese Medicinal Materials Research. Singapore: World Scientific, 1985: 433-452.
12. Kugelman M et al. Indicine-N-oxide: the antitumor principle of Heliotropium indicum. Lloydia 1976; 39: 125-128.
13. Singh B et al. Antineoplastic and antiviral screening of pyrrolizidine alkaloids from Heliotropium subulatum. Pharm Biol 2002; 40(8): 581-586.
14. Culvenor CCJ. Tumor-inhibiotory activity of pyrrolizidine alkaloids. J Pharm Sci 1968; 57(7): 1112-1117.
15. Toma W et al. Preventive activity of pyrrolizidine alkaloids from Senecio brasiliensis (Asteraceae) on gastric and duodenal induced ulcer on mice and rats. J Ethnopharmacol 2004; 95: 345-351.
16. Barret SV, Barrett MP. Anti-sleeping sickness drugs and cancer chemotherapy. Parasitol Today 2000; 16(1): 7-9.
17. Merschjohann K et al. In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense. Planta Med 2001; 67(7): 623-627.
18. Baltz T et al. Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J 1985; 4: 1273-1277.
19. Räz B et al. The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T. b. rhodesiense and T. b. gambiense) in vitro. Acta Trop 1997; 68: 139-147.
20. Rolón M et al. Development of resazurin microtiter assay for drug testing of Trypanosoma cruzi epimastigotes. Parasitol Res 2006; 99: 103-107.
21. Huber W, Koella JC. A comparison of three methods of estimating EC50 in studies of drug resistance of malaria parasites. Acta Trop 1993; 55: 257-261.
22. Abebe D et al. Illustrated Checklist: Medicinal Plants and Other Useful Plants of Ethiopia, 1st edn. Singapore: Camerapix, 2003.
23. Abate G. Etse Debdabe: Ethiopian Traditional Medicine. Addis Ababa: Addis Ababa University Press, 1989.
24. Wondimu T et al. Ethnobotanical study of medicinal plants around 'Dheeraa' town, Arsi Zone, Ethiopia. J Ethnopharmacol 2007; 112: 152-161.
25. Mun'im A et al. Antioxidative compounds from Crotalaria sessiliflora. Biosci Biotechnol Biochem 2003; 67(2): 410-414.
26. Ahmed B et al. Crotalic and emarginellic acids: two triterpenes from Crotalaria emarginella and anti-inflammatory and antihepatotoxic activity of crotalic acid. Phytochemistry 2006; 67: 956-964.
27. Wink M et al. Modes of action of allelochemical alkaloids: interaction with neuroreceptors, DNA, and other molecular targets. J Chem Ecol 1998; 24(11): 1881-1937.
28. Schmeller T et al. Allelochemical activities of pyrrolizidine alkaloids: interactions with neuroreceptors and acetylcholine related enzymes. J Chem Ecol 1997; 23(2): 399-416.
29. Desta B. Ethiopian traditional herbal drugs. Part II: Antimicrobial activity of 63 medicinal plants. J Ethnopharmacol 1993; 39: 129-139.
30. Giday M et al. An ethnobotanical study of medicinal plants used by the Zay people in Ethiopia. J Ethnopharmacol 2003; 85: 43-52.
31. Yineger H et al. Ethnoveterinary medicinal plants at Bale Mountains National Park, Ethiopia. J Ethnopharmacol 2007; 112: 55-70.
32. El-Shazly A et al. Pyrrolizidine alkaloids of Cynoglossum officinale and Cynoglossum amabile (Family Boraginaceae). Biochem Syst Ecol 1996; 24(5): 415-421.
33. Jin Y-P et al. Chemical constituents from Cynoglossum gansuense. Helv Chim Acta 2007; 90: 776-782.
34. Guntern A et al. Quinones from Heliotropium ovalifolium. Phytochemistry 2001; 58: 631-635.
35. Villarroel L et al. Heliotropium huascoense resin exudate: chemical constituents and defensive properties. J Nat Prod 2001; 64(9): 1123-1126.
36. Singh B, Dubey MM. Estimation of triterpenoids from Heliotropium marifolium Koen. Ex Retz. in vivo and in vitro. I. Antimicrobial screening. Phytother Res 2001; 15: 231-234.
37. Njoroge GN, Bussmann RW. Herbal usage and informant consensus in ethnoveterinary management of cattle diseases among the Kikuyus (Central Kenya). J Ethnopharmacol 2006; 108: 332-339.
38. Wink M. Bioprospecting: the search for bioactive lead structures from nature. In: Kayser O, Quax WJ, eds. Medicinal Plant Biotechnology: from Basic Research to Industrial Applications. Weinheim: Wiley-VCH, 2007: 97-116.
39. Mikus J et al. In vitro effect of essential oils and isolated monoand sesquiterpenes on Leishmania major and Trypanosoma brucei. Planta Med 2000; 66: 366-338.
40. Asres K et al. Chemical composition and antimicrobial activity of the flower essential oil of Solanecio gigas (Vatke) C. Jeffrey. Int J Essent Oil Ther 2007; 1(3): 135-139.