Quercetin attenuates myocardial ischemia-reperfusion injury via downregulation of the HMGB1-TLR4-NF-кB signaling pathway

American Journal of Translational Research

Volumn 10, Issue 5, 2018, Pages 1273-1283

  Dong, Li Ya ^a   Chen, Feng ^b   Xu, Min ^a   Yao, Li Ping ^a   Zhang, Yun Jiao ^a   Zhuang, Yu ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Inflammation; Myocardial ischemia reperfusion; Quercetin

Indexed keywords

CYTOKINE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; QUERCETIN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ELECTROCARDIOGRAM; EXPERIMENTAL MYOCARDIAL ISCHEMIA; GENETIC TRANSFECTION; HEART INFARCTION; HEART INJURY; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART PROTECTION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; ISOLATED HEART; LEFT CORONARY ARTERY; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NONHUMAN; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; ST SEGMENT ELEVATION; WESTERN BLOTTING;

EID: 85047664305     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Hu Q, Wei B, Wei L, Hua K, Yu X, Li H and Ji H. Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in beagle dogs through NLRP3 inflammasome. Int J Cardiol 2015; 196: 183-92.
2. Zhu L, Wei T, Gao J, Chang X, He H, Luo F, Zhou R, Ma C, Liu Y and Yan T. The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation. Apoptosis 2015; 20: 1433-1443.
3. Weinreuter M, Kreusser MM, Beckendorf J, Schreiter FC, Leuschner F, Lehmann LH, Hofmann KP, Rostosky JS, Diemert N and Xu C. CaM kinase II mediates maladaptive post-in- farct remodeling and pro-inflammatory che-moattractant signaling but not acute myocardial ischemia/reperfusion injury. EMBO Mol Med 2014; 6: 1231-45.
4. Hua K, Sheng X, Li T, Wang L, Zhang Y, Huang Z and Ji H. The edaravone and 3-n-bu-tylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats. Acta Pharmacol Sin 2015; 36: 917-927.
5. Andrassy M, Volz HC, Igwe JC, Funke B, Eich-berger SN, Kaya Z, Buss S, Autschbach F, Ple-ger ST and Lukic IK. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008; 117: 3216-26.
6. Klune JR, Dhupar R, Cardinal J, Billiar TR and Tsung A. HMGB1: endogenous danger signaling. Mol Med 2008; 14: 476-84.
7. Volz HC, Laohachewin D, Schellberg D, Wien-brandt AR, Nelles M, Zugck C, Kaya Z, Katus HA and Andrassy M. HMGB1 is an independent predictor of death and heart transplantation in heart failure. Clin Res Cardiol 2012; 101: 427-35.
8. Erden IM and Kahraman A. The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats. Toxicology 2000; 154: 21-29.
9. Lee M, Son M, Ryu E, Yu SS, Kim JG, Kang BW, Sung GH, Cho H and Kang H. Quercetin-in-duced apoptosis prevents EBV infection. Oncotarget 2015; 6: 12603-12624.
10. Qin YH, Dai SM, Tang GS, Zhang J, Ren D, Wang ZW and Shen Q. HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products. J Immunol 2009; 183: 6244-50.
11. Karuppagounder V, Arumugam S, Thandava-rayan RA, Pitchaimani V, Sreedhar R, Afrin R, Harima M, Suzuki H, Nomoto M and Miyashita S. Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. Exp Dermatol 2015; 24: 418-23.
12. van Beijnum JR, Buurman WA and Griffioen AW. Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis 2008; 11: 91-99.
13. de Haan JJ, Smeets MB, Pasterkamp G and Ar-slan F. Danger signals in the initiation of the inflammatory response after myocardial infarction. Mediators Inflamm 2013; 2013: 206039.
14. Favre J, Musette P, Douinechinard V, Laude K, Henry JP, Arnal JF, Thuillez C and Richard V. Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol 2007; 27: 1064-71.
15. Zhang K, Liu J, You X, Kong P, Song Y, Cao L, Yang S, Wang W, Fu Q and Ma Z. P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice. Neurosci Lett 2015; 613: 60-65.
16. Chorianopoulos E, Heger T, Lutz M, Frank D, Bea F, Katus HA and Frey N. FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. Basic Res Cardiol 2010; 105: 301-13.