Deficiency of natriuretic peptide receptor 2 promotes bicuspid aortic valves, aortic valve disease, left ventricular dysfunction, and ascending aortic dilatations in mice

Circulation Research

Volumn 122, Issue 3, 2018, Pages 405-416

  Blaser, Mark C ^a,b   Wei, Kuiru ^b   Adams, Rachel L E ^a,b   Zhou, Yu Qing ^a,c   Caruso, Laura Lee ^a,e   Mirzaei, Zahra ^a,e   Lam, Alan Y L ^a,b   Tam, Richard K K ^a,b   Zhang, Hangjun ^a,d   Heximer, Scott P ^a,d   Henkelman, R Mark ^c   Simmons, Craig A ^a,b,e  

^a TED ROGERS CENTRE FOR HEART RESEARCH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aortic aneurysm; Aortic valve stenosis; Bicuspid aortic valve; C type natriuretic peptide; Natriuretic peptide receptor 2

Indexed keywords

COLLAGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; NATRIURETIC PEPTIDE RECEPTOR B; NATRIURETIC PEPTIDE TYPE C; ATRIAL NATRIURETIC FACTOR RECEPTOR; CYCLIC GMP DEPENDENT PROTEIN KINASE 1; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEOGLYCAN;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC VALVE DISEASE; ARTERY CALCIFICATION; ARTICLE; ASCENDING AORTIC DILATATION; BICUSPID AORTIC VALVE; BONE DEVELOPMENT; CARDIAC MUSCLE CELL; CONTROLLED STUDY; DISEASE EXACERBATION; DOWN REGULATION; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; FIBROGENESIS; HEART DILATATION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE FIBROSIS; IN VITRO STUDY; IN VIVO STUDY; LOW DENSITY LIPOPROTEIN RECEPTOR KNOCKOUT MOUSE; MALE; MOUSE; MYOFIBROGENESIS; NEWBORN; NONHUMAN; PIG; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN SYNTHESIS; PROTEOGLYCAN SYNTHESIS; SIGNAL TRANSDUCTION; VALVE INTERSTITIAL CELL; WILD TYPE MOUSE; ABNORMALITIES; ANIMAL; AORTA; AORTIC ANEURYSM; AORTIC VALVE; AORTIC VALVE STENOSIS; BIOSYNTHESIS; CALCINOSIS; CELL CULTURE; COMPLICATION; CYTOLOGY; DEFICIENCY; GENETICS; HEART LEFT VENTRICLE FUNCTION; HYPERLIPIDEMIA; KNOCKOUT MOUSE; METABOLISM; MYOFIBROBLAST; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VALVULAR HEART DISEASE;

ANIMALS; AORTA; AORTIC ANEURYSM; AORTIC VALVE; AORTIC VALVE STENOSIS; CALCINOSIS; CELLS, CULTURED; COLLAGEN; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE I; EXTRACELLULAR MATRIX; HEART VALVE DISEASES; HYPERLIPIDEMIAS; MICE; MICE, KNOCKOUT; MYOFIBROBLASTS; NATRIURETIC PEPTIDE, C-TYPE; OSTEOGENESIS; PROTEOGLYCANS; RECEPTORS, ATRIAL NATRIURETIC FACTOR; RECEPTORS, LDL; SWINE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 85047663940     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.311194     Document Type: Article

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