Editorial Focus: CFTR-dependent bicarbonate secretion by Calu-3 cells

Physiological Reports

Volumn 6, Issue 10, 2018, Pages

  Rubenstein, Ronald C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FORSKOLIN; OSMOTIC AGENT; PENDRIN; SODIUM CHLORIDE; CFTR PROTEIN, HUMAN;

APICAL MEMBRANE; CALU-3 CELL LINE; CYSTIC FIBROSIS; EDITORIAL; GENE MUTATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SECRETION (PROCESS); BREATHING DISORDER; COMPLICATION; METABOLISM; TUMOR CELL LINE;

BICARBONATES; CELL LINE, TUMOR; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; RESPIRATION DISORDERS;

EID: 85047507011     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.13691     Document Type: Editorial

References (12)

1. Adams, K. M., V. Abraham, D. Spielman, J. K. Kolls, R. C. Rubenstein, G. E. Conner, et al. 2014. IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. PLoS ONE 9:e103263.
2. Ballard, S. T., L. Trout, A. Mehta, and S. K. Inglis. 2002. Liquid secretion inhibitors reduce mucociliary transport in glandular airways. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L329–L335.
3. Chen, E. Y., N. Yang, P. M. Quinton, and W. C. Chin. 2010. A new role for bicarbonate in mucus formation. Am. J. Physiol. Lung Cell. Mol. Physiol. 299:L542–L549.
4. Choi, J. Y., D. Muallem, K. Kiselyov, M. G. Lee, P. J. Thomas, and S. Muallem. 2001. Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis. Nature 410:94–97.
5. Garnett, J. P., E. Hickman, R. Burrows, P. Hegyi, L. Tiszlavicz, A. W. Cuthbert, et al. 2011. Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells. J. Biol. Chem. 286:41069–41082.
6. Haggie, P. M., P. W. Phuan, J. A. Tan, L. Zlock, W. E. Finkbeiner, and A. S. Verkman. 2016. Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis. FASEB J. 30:2187–2197.
7. Hoegger, M. J., A. J. Fischer, J. D. McMenimen, L. S. Ostedgaard, A. J. Tucker, M. A. Awadalla, et al. 2014. Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science 345:818–822.
8. Huang, J., D. Kim, J. Shan, A. Abu-Arish, Y. Luo, and J. W. Hanrahan. 2018. Most bicarbonate secretion by Calu-3 cells is mediated by CFTR and independent of pendrin. Physiol. Rep. 6:e13641.
9. Joo, N. S., T. Irokawa, R. C. Robbins, and J. J. Wine. 2006. Hyposecretion, not hyperabsorption, is the basic defect of cystic fibrosis airway glands. J. Biol. Chem. 281:7392–7398.
10. Ko, S. B., N. Shcheynikov, J. Y. Choi, X. Luo, K. Ishibashi, P. J. Thomas, et al. 2002. A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J. 21:5662–5672.
11. Pezzulo, A. A., X. X. Tang, M. J. Hoegger, M. H. Alaiwa, S. Ramachandran, T. O. Moninger, et al. 2012. Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature 487:109–113.
12. Yang, N., M. A. Garcia, and P. M. Quinton. 2013. Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2 + -mediated mucin exocytosis. J. Physiol. 591:4581–4593.