White blood cells count as an indicator to identify whether obesity leads to increased risk of type 2 diabetes

Diabetes Research and Clinical Practice

Volumn 141, Issue , 2018, Pages 140-147

  Gu, Yeqing ^a   Hu, Kuiru ^a   Huang, Yuhan ^a   Zhang, Qing ^a   Liu, Li ^a   Meng, Ge ^a   Wu, Hongmei ^a   Xia, Yang ^a   Bao, Xue ^a   Shi, Hongbin ^a   Wang, Honglei ^a   Sun, Shaomei ^a   Wang, Xing ^a   Zhou, Ming ^a   Jia, Qiyu ^a   Song, Kun ^a   Niu, Kaijun ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Inflammatory levels; Obesity; Type 2 diabetes; White blood cell count

Indexed keywords

ADULT; ARTICLE; CLINICAL INDICATOR; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSESSMENT; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INFLAMMATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROSPECTIVE STUDY; RISK ASSESSMENT; BLOOD; INCIDENCE; LEUKOCYTE; METABOLISM; MIDDLE AGED; PATHOLOGY; RISK FACTOR;

ADULT; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INCIDENCE; INFLAMMATION; LEUKOCYTES; MALE; MIDDLE AGED; OBESITY; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 85046850381     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2018.04.041     Document Type: Article

References (39)

1. Denis, G.V., Obin, M.S., ‘Metabolically healthy obesity’: origins and implications. Mol Aspects Med 34 (2013), 59–70.
2. Mokdad, A.H., Ford, E.S., Bowman, B.A., Dietz, W.H., Vinicor, F., Bales, V.S., et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289 (2003), 76–79.
3. Van Gaal, L.F., Mertens, I.L., De Block, C.E., Mechanisms linking obesity with cardiovascular disease. Nature 444 (2006), 875–880.
4. Kelly, T., Yang, W., Chen, C.S., Reynolds, K., He, J., Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 32 (2008), 1431–1437.
5. Smith, S.R., Lovejoy, J.C., Greenway, F., Ryan, D., deJonge, L., de la Bretonne, J., et al. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism 50 (2001), 425–435.
6. Atzmon, G., Yang, X.M., Muzumdar, R., Ma, X.H., Gabriely, I., Barzilai, N., Differential gene expression between visceral and subcutaneous fat depots. Horm Metab Res 34 (2002), 622–628.
7. Ouwens, D.M., Sell, H., Greulich, S., Eckel, J., The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease. J Cell Mol Med 14 (2010), 2223–2234.
8. Hinnouho, G.M., Czernichow, S., Dugravot, A., Nabi, H., Brunner, E.J., Kivimaki, M., et al. Metabolically healthy obesity and the risk of cardiovascular disease and type 2 diabetes: the Whitehall II cohort study. Eur Heart J 36 (2015), 551–559.
9. Vaag, A., Lund, S.S., Non-obese patients with type 2 diabetes and prediabetic subjects: distinct phenotypes requiring special diabetes treatment and (or) prevention?. Appl Physiol Nutr Metab 32 (2007), 912–920.
10. Spalding, K.L., Arner, E., Westermark, P.O., Bernard, S., Buchholz, B.A., Bergmann, O., et al. Dynamics of fat cell turnover in humans. Nature 453 (2008), 783–787.
11. Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., et al. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol, 9, 2008, R14.
12. Halberg, N., Khan, T., Trujillo, M.E., Wernstedt-Asterholm, I., Attie, A.D., Sherwani, S., et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 29 (2009), 4467–4483.
13. Khan, T., Muise, E.S., Iyengar, P., Wang, Z.V., Chandalia, M., Abate, N., et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29 (2009), 1575–1591.
14. Divoux, A., Tordjman, J., Lacasa, D., Veyrie, N., Hugol, D., Aissat, A., et al. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 59 (2010), 2817–2825.
15. Skurk, T., Alberti-Huber, C., Herder, C., Hauner, H., Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92 (2007), 1023–1033.
16. Hotamisligil, G.S., Inflammation and metabolic disorders. Nature 444 (2006), 860–867.
17. Hotamisligil, G.S., Inflammation, metaflammation and immunometabolic disorders. Nature 542 (2017), 177–185.
18. Prattichizzo, F., De Nigris, V., Spiga, R., Mancuso, E., La Sala, L., Antonicelli, R., et al. Inflammageing and metaflammation: the yin and yang of type 2 diabetes. Ageing Res Rev 41 (2018), 1–17.
19. Nakanishi, N., Yoshida, H., Matsuo, Y., Suzuki, K., Tatara, K., White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men. Diabetologia 45 (2002), 42–48.
20. Zhang, H., Yang, Z., Zhang, W., Niu, Y., Li, X., Qin, L., et al. White blood cell subtypes and risk of type 2 diabetes. J Diabetes Complicat 31 (2017), 31–37.
21. Twig, G., Afek, A., Shamiss, A., Derazne, E., Tzur, D., Gordon, B., et al. White blood cells count and incidence of type 2 diabetes in young men. Diabetes Care 36 (2013), 276–282.
22. Vozarova, B., Weyer, C., Lindsay, R.S., Pratley, R.E., Bogardus, C., Tataranni, P.A., High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51 (2002), 455–461.
23. Consultation, W.H.O.E., Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363 (2004), 157–163.
24. Zhou, B.F., Cooperative Meta-Analysis Group of the Working Group on Obesity in C. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults–study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 15 (2002), 83–96.
25. Chen, C., Lu, F.C., Department of Disease Control Ministry of Health PRC, The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci 17:Suppl (2004), 1–36.
26. American Diabetes Association, Standards of medical care in diabetes–2013. Diabetes Care 36:Suppl 1 (2013), S11–S66.
27. Alberti, K.G., Eckel, R.H., Grundy, S.M., Zimmet, P.Z., Cleeman, J.I., Donato, K.A., et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120 (2009), 1640–1645.
28. Vatcheva, K.P., Fisher-Hoch, S.P., Rahbar, M.H., Lee, M., Olvera, R.L., McCormick, J.B., Association of total and differential white blood cell counts to development of type 2 diabetes in Mexican Americans in Cameron County Hispanic Cohort. Diabetes Res 1 (2015), 103–112.
29. Lionetti, L., Mollica, M.P., Lombardi, A., Cavaliere, G., Gifuni, G., Barletta, A., From chronic overnutrition to insulin resistance: the role of fat-storing capacity and inflammation. Nutr Metab Cardiovasc Dis 19 (2009), 146–152.
30. de Ferranti, S., Mozaffarian, D., The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 54 (2008), 945–955.
31. Arner, E., Westermark, P.O., Spalding, K.L., Britton, T., Ryden, M., Frisen, J., et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59 (2010), 105–109.
32. Wanders, D., Ghosh, S., Stone, K.P., Van, N.T., Gettys, T.W., Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. BioFactors 40 (2014), 13–26.
33. Bluher, S., Schwarz, P., Metabolically healthy obesity from childhood to adulthood – does weight status alone matter?. Metabolism 63 (2014), 1084–1092.
34. Karelis, A.D., Metabolically healthy but obese individuals. Lancet 372 (2008), 1281–1283.
35. Mohamed-Ali, V., Goodrick, S., Rawesh, A., Katz, D.R., Miles, J.M., Yudkin, J.S., et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82 (1997), 4196–4200.
36. Kishimoto, T., The biology of interleukin-6. Blood 74 (1989), 1–10.
37. Tanaka, T., Kishimoto, T., The biology and medical implications of interleukin-6. Cancer Immunol Res 2 (2014), 288–294.
38. Rotter, V., Nagaev, I., Smith, U., Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278 (2003), 45777–45784.
39. Prattichizzo, F., De Nigris, V., Mancuso, E., Spiga, R., Giuliani, A., Matacchione, G., et al. Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages. Redox Biol 15 (2018), 170–181.