Comparison of surgical and medical therapy for type 2 diabetes in severely obese adolescents

JAMA Pediatrics

Volumn 172, Issue 5, 2018, Pages 452-460

  Inge, Thomas H ^a   Laffel, Lori M ^b   Jenkins, Todd M ^c   Marcus, Marsha D ^d,j   Leibel, Natasha I ^e,k   Brandt, Mary L ^f   Haymond, Morey ^f   Urbina, Elaine M ^c   Dolan, Lawrence M ^c   Zeitler, Philip S ^a,o   McKay, Siripoo ^f   Anderson, Barbara ^f   Bush, Cresendo ^f   Gunn, Sheila ^f   Holden, Heather ^f   Jones, Mary ^f   Jeha, George ^f   McGirk, Sue ^f   Thamotharan, Sneha ^f   Cuttler, Leona ^g   Abrams, Ericka ^g   Casey, Terri ^g   Dahms, Bill ^g   Ievers Landis, Carolyn ^g   Kaminski, Beth ^g   Koontz, Michaela ^g   MacLeish, Sarah ^g   McGuigan, Paul ^g   Narasimhan, Sumana ^g   Geffner, Mitchell ^h   Barraza, Veronica ^h   Chang, Nancy ^h   Conrad, Barry ^h   Dreimane, Daina ^h   Estrada, Silvia ^h   Fisher, Lynda ^h   Fleury Milfort, Evelyne ^h   Hernandez, Socorro ^h   Hollen, Barbara ^h   Kaufman, Francine ^h   Law, Emily ^h   Mansilla, Vanessa ^h   Miller, Debra ^h   Muñoz, Cynthia ^h   Ortiz, Rosa ^h   Ward, Andriette ^h   Wexler, Keren ^h   Xu, Y K ^h   Yasuda, Patrice ^h   Levitt Katz, Lorraine ⁱ   Berkowitz, Robert ⁱ   Boyd, Sakeenah ⁱ   Johnson, Bonnie ⁱ   Kaplan, Joan ⁱ   Keating, Catherine ⁱ   Lassiter, Chad ⁱ   Lipman, Terri ⁱ   McGinley, Gerre ⁱ   McKnight Menci, Heather ⁱ   Schwartzman, Beth ⁱ   Willi, Steven ⁱ   Arslanian, Silva ^j   Bacha, Fida ^j   Foster, Sally ^j   Galvin, Bryan ^j   Hannon, Tamara ^j   Kriska, Andrea ^j   Libman, Ingrid ^j   Porter, Kristin ^j   Songer, Thomas ^j   Venditti, Elizabeth ^j   Goland, Robin ^k   Gallagher, Dympna ^k   Kringas, Patricia ^k   Ng, Debbie ^k   Ovalles, Martin ^k   Seidman, Daniel ^k   Goebel Fabbri, Ann ^b   Hall, Melanie ^b   Higgins, Laurie ^b   Keady, Joyce ^b   Malloy, Maureen ^b   Milaszewski, Kerry ^b   Rasbach, Lisa ^b   Nathan, David ^l   Angelescu, Amanda ^l   Bissett, Laurie ^l   Ciccarelli, Carol ^l   Delahanty, Linda ^l   Goldman, Valerie ^l   Hardy, Olga ^l   Larkin, Mary ^l   Levitsky, Lynne ^l   McEachern, Rebecca ^l   Norman, Dennis ^l   Nwosu, Benjamin ^l   Park Bennett, Soja ^l   Richards, Denise ^l   Sherry, Nicole ^l   Steiner, Barbara ^l   Tollefsen, Sherida ^m   Carnes, Silvia ^m   Dempsher, David ^m   Flomo, David ^m,r   Whelan, Theresa ^m   Wolff, Bonita ^m   Weinstock, Ruth ⁿ   Bowerman, Deborah ⁿ   Bristol, Suzan ⁿ   Bulger, Jane ⁿ   Hartsig, Jennifer ⁿ   Izquierdo, Roberto ⁿ   Kearns, Joanne ⁿ   Saletsky, Ron ⁿ   Trief, Paula ⁿ   Abramson, Natalie ^o   Bradhurst, Amanda ^o   Celona Jacobs, Nicole ^o   Higgins, Janine ^o   Kelsey, Megan ^o   Klingensmith, Georgeanna ^o   Nadeau, Kristen ^o   Witten, Teresa ^o   Copeland, Kenneth ^p   Boss, Evynn ^p   Brown, Ryan ^p   Chadwick, Jennifer ^p   Chalmers, Laura ^p   Chernausek, Steven ^p   Hebensperger, Ashley ^p   Macha, Chris ^p   Newgent, Rebecca ^p   Nordyke, Allison ^p   Olson, Donna ^p   Poulsen, Tawney ^p   Pratt, Lauren ^p   Preske, Jeff ^p   Schanuel, Jill ^p   Sternlof, Steve ^p   Lynch, Jane ^q   Amodei, Nancy ^q   Barajas, Rose Ann ^q   Cody, Catherine ^q   Hale, Dan ^q   Hernandez, J ^q   Ibarra, Cori ^q   Morales, Elisa ^q   Rivera, Semilla ^q   Rupert, Guadalupe ^q   Wauters, Aimee ^q   White, Neil ^r   Arbeláez, Ana ^r   Jones, Jackie ^r   Jones, Tracy ^r   Sadler, Michelle ^r   Tanner, Marilyn ^r   Timpson, Alexis ^r   Welch, Robinson ^r   Caprio, Sonia ^s   Grey, Margaret ^s   Guandalini, Cindy ^s   Lavietes, Sylvia ^s   Rose, Paulina ^s   Syme, Amy ^s   Tamborlane, William ^s   Hirst, Kathryn ^t   Edelstein, Sharon ^t   Feit, Preethy ^t   Grover, Nisha ^t   Long, Christen ^t   Pyle, Laura ^t   Linder, Barbara ^u   Marcovina, Santica ^v   Harting, Jessica ^v   Shepherd, John ^w   Fan, Bo ^w   Marquez, Lorena ^w   Sherman, Mary ^w   Wang, Jeff ^w   Nichols, Michele ^x   Mayer Davis, Beth ^x   Liu, Yuan ^x   Lima, Joao ^y   Gidding, Sam ^y   Puccella, Joann ^y   Ricketts, Erin ^y   Danis, Ronald ^z   Domalpally, Amitha ^z   Goulding, Anne ^z   Neill, Sherri ^z   Vargo, Pam ^z   Wilfley, Denise ^aa   Aldrich Rasche, Deb ^aa   Franklin, K ^aa   Massmann, Cherie ^aa   O'Brien, Dennis ^aa   Patterson, Jeremy ^aa   Tibbs, Tiffany ^aa   Van Buren, Dorothy ^aa   Palmert, Mark ^ab   Ratner, Robert ^ac   Dremaine, Daina ^ad   Silverstein, Janet ^ae   Simmons, Mark ^c   Sherman, Vadim ^f   Lee, Margaret Callie ^f   Allen, David ^f   Caston, Natoya ^f   Turybury, Keri ^f   Washington, Gia ^f   Price, Karin ^f   Clements, Ronald ^af   Stahl, Richard ^af   Bray, Molly ^af   Haynes, Beverly ^af   Austin, Heather ^af   Cushing, Constance ^af   Ramanathan, Ramesh ^ag   McCloskey, Carol A ^ag   Eid, George M ^ag   Eagleton, Jessie ^ag   Gourash, William ^ag   Lee, Lindsay ^ag   Pierson, Sheila ^ag   Gibbs, Catherine ^ag   Farrell, Dana ^ag   Coburn, Christopher ^ag   Rofey, Dana ^ag   Search, Rebecca ^ag   Shaw, Mark ^ag   Shirley, Eleanor ^ag   Topolski, Kevin ^ag   Teich, Steven ^ah   Browne, Allen ^ah   Carter, Karen ^ah   Helton, Melinda ^ah   Bowen, Bonny ^ah   Yensel, Cynthia ^ah   Guittar, Patsy ^ah   Lear, Deanna ^ah   Murray, Robert David ^ah   Hedge, Andrea ^ah   Smith, Kevin ^ah   Baughcum, Amy ^ah   Wentzel, Grace ^ah   Davies, Paula ^ah   Evans, Mary ^u   Marcovina, Santica M ^v   Kleiner, David E ^ai   Daniels, Stephen ^aj   more..

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b JOSLIN DIABETES CENTER   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g CASE WESTERN RESERVE UNIVERSITY   (United States)

^h CHILDREN S HOSPITAL LOS ANGELES   (United States)

ⁱ CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^j CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^k Department of Medicine   (United States)

^l MASSACHUSETTS GENERAL HOSPITAL   (United States)

^m SAINT LOUIS UNIVERSITY   (United States)

ⁿ SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^o UNIVERSITY OF COLORADO   (United States)

^p UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^q UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^r WASHINGTON UNIVERSITY   (United States)

^s YALE UNIVERSITY   (United States)

^t GEORGE WASHINGTON UNIVERSITY   (United States)

^u NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^v UNIVERSITY OF WASHINGTON   (United States)

^w UNIVERSITY OF CALIFORNIA   (United States)

^x UNIVERSITY OF SOUTH CAROLINA   (United States)

^y JOHNS HOPKINS UNIVERSITY   (United States)

^z Fundus Photography Reading Center (University of Wisconsin)   (United States)

^aa Lifestyle Program Core (Washington University)   (United States)

^ab HOSPITAL FOR SICK CHILDREN   (Canada)

^ac MEDSTAR RESEARCH INSTITUTE   (United States)

^ad TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^ae UNIVERSITY OF FLORIDA   (United States)

^af CHILDREN S HOSPITAL OF ALABAMA   (United States)

^ag UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^ah NATIONWIDE CHILDREN S HOSPITAL   (United States)

^ai NATIONAL CANCER INSTITUTE   (United States)

^aj UNIVERSITY OF COLORADO   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CREATININE; CYSTATIN C; GLIPIZIDE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; METFORMIN; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; GLYCOSYLATED HEMOGLOBIN;

ADOLESCENT; ADVERSE EVENT; ALBUMIN BLOOD LEVEL; ARTICLE; BARIATRIC SURGERY; BODY MASS; CARDIOVASCULAR RISK; CHOLECYSTECTOMY; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; DYSLIPIDEMIA; ELEVATED BLOOD PRESSURE; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLYCEMIC CONTROL; HOSPITAL READMISSION; HUMAN; INSULIN BLOOD LEVEL; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; ROUX-EN-Y GASTRIC BYPASS; SECONDARY ANALYSIS; SLEEVE GASTRECTOMY; TRIACYLGLYCEROL BLOOD LEVEL; ANTHROPOMETRY; BLOOD; CHILD; CLINICAL TRIAL; COMPLICATION; LONGITUDINAL STUDY; METABOLISM; MORBID OBESITY; MULTICENTER STUDY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ANTHROPOMETRY; BARIATRIC SURGERY; BLOOD GLUCOSE; BODY MASS INDEX; CHILD; DIABETES MELLITUS, TYPE 2; FEMALE; GLYCATED HEMOGLOBIN A; HUMANS; HYPOGLYCEMIC AGENTS; LONGITUDINAL STUDIES; MALE; METFORMIN; OBESITY, MORBID;

EID: 85046740894     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2017.5763     Document Type: Article

References (30)

1. Fazeli Farsani S, van der Aa MP, van der Vorst MM, Knibbe CA, de Boer A. Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches. Diabetologia. 2013;56(7):1471-1488
2. Daniels SR, Arnett DK, Eckel RH, et al. Overweight in children and adolescents: pathophysiology, consequences, prevention, and treatment. Circulation. 2005;111(15):1999-2012
3. Dabelea D, Bell RA, D'Agostino RB Jr, et al; Writing Group for the SEARCH for Diabetes in Youth Study Group. Incidence of diabetes in youth in the United States. JAMA. 2007;297(24):2716-2724
4. Zeitler P, Hirst K, Pyle L, et al; TODAY Study Group. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med. 2012;366 (24):2247-2256
5. Gottschalk M, Danne T, Vlajnic A, Cara JF. Glimepiride versus metformin as monotherapy in pediatric patients with type 2 diabetes: a randomized, single-blind comparative study. Diabetes Care. 2007;30(4):790-794
6. Rosenstock J, Rood J, Cobitz A, Huang C, Garber A. Improvement in glycaemic control with rosiglitazone/metformin fixed-dose combination therapy in patients with type 2 diabetes with very poor glycaemic control. Diabetes Obes Metab. 2006;8(6):643-649
7. Narasimhan S,Weinstock RS. Youth-onset type 2 diabetes mellitus: lessons learned from the TODAY study. Mayo Clin Proc. 2014;89(6):806-816
8. Tryggestad JB, Willi SM. Complications and comorbidities of T2DM in adolescents: findings from the TODAY clinical trial. J Diabetes Complications. 2015;29(2):307-312
9. Linder BL, Fradkin JE, Rodgers GP. The TODAY study: an NIH perspective on its implications for research. Diabetes Care. 2013;36(6):1775-1776
10. Nadeau KJ, Anderson BJ, Berg EG, et al. Youth-onset type 2 diabetes consensus report: current status, challenges, and priorities. Diabetes Care. 2016;39(9):1635-1642
11. Copeland KC, Zeitler P, Geffner M, et al; TODAY Study Group. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab. 2011;96(1):159-167
12. Inge TH, Courcoulas AP, Jenkins TM, et al; Teen-LABS Consortium.Weight loss and health status 3 years after bariatric surgery in adolescents. N Engl J Med. 2016;374(2):113-123
13. American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care. 2017;40 (suppl 1):S11-S24
14. Zeitler P, Epstein L, GreyM, et al; TODAY Study Group. Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy ofmetformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes. Pediatr Diabetes. 2007;8(2): 74-87
15. Buse JB, Caprio S, CefaluWT, et al. How do we define cure of diabetes? Diabetes Care. 2009;32 (11):2133-2135
16. Al-Saeed AH, Constantino MI, Molyneaux L, et al. An inverse relationship between age of type 2 diabetes onset and complication risk and mortality: the impact of youth-onset type 2 diabetes. Diabetes Care. 2016;39(5):823-829
17. Inge TH, Krebs NF, Garcia VF, et al. Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics. 2004; 114(1):217-223
18. Pratt JS, Lenders CM, Dionne EA, et al. Best practice updates for pediatric/adolescent weight loss surgery. Obesity (Silver Spring). 2009;17(5): 901-910
19. Michalsky M, Reichard K, Inge T, Pratt J, Lenders C; American Society forMetabolic and Bariatric Surgery. ASMBS pediatric committee best practice guidelines. Surg Obes Relat Dis. 2012; 8(1):1-7
20. Aikenhead A, Lobstein T, Knai C. Review of current guidelines on adolescent bariatric surgery. Clin Obes. 2011;1(1):3-11
21. Schauer PR, Bhatt DL, Kirwan JP, et al; STAMPEDE Investigators. Bariatric surgery versus intensive medical therapy for diabetes-3-year outcomes. N Engl J Med. 2014;370(21):2002-2013
22. Schauer PR, Bhatt DL, Kirwan JP, et al; STAMPEDE Investigators. Bariatric surgery versus intensive medical therapy for diabetes: 5-year outcomes. N Engl J Med. 2017;376(7):641-651
23. Sjöström L, Peltonen M, Jacobson P, et al. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. JAMA. 2014;311 (22):2297-2304
24. Rubino F, Nathan DM, Eckel RH, et al; Delegates of the 2nd Diabetes Surgery Summit. Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations. Surg Obes Relat Dis. 2016;12 (6):1144-1162
25. Manning S, Pucci A, Batterham RL. GLP-1: a mediator of the beneficial metabolic effects of bariatric surgery? Physiology (Bethesda). 2015;30 (1):50-62
26. Kelly AS, Ryder JR, Marlatt KL, Rudser KD, Jenkins T, Inge TH. Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity. Int J Obes (Lond). 2016;40(2):275-280
27. Ryan KK, Tremaroli V, Clemmensen C, et al. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature. 2014;509(7499): 183-188
28. Aron-Wisnewsky J, Clement K. The effects of gastrointestinal surgery on gut microbiota: potential contribution to improved insulin sensitivity. Curr Atheroscler Rep. 2014;16(11):454
29. Bout-Tabaku S, Michalsky MP, Jenkins TM, et al. Musculoskeletal pain, self-reported physical function, and quality of life in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort. JAMA Pediatr. 2015;169(6):552-559
30. Pi-Sunyer X. The Look AHEAD Trial: a review and discussion of its outcomes. Curr Nutr Rep. 2014;3(4):387-391.