메뉴 건너뛰기




Volumn 3, Issue 4, 2014, Pages 387-391

The Look AHEAD Trial: A Review and Discussion of Its Outcomes

Author keywords

Cardiovascular outcomes; Cost; Diabetic complications; Intensive lifestyle intervention; Obese; Overweight; Quality of life; Randomized controlled trial; Type 2 diabetes

Indexed keywords

GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; TETRAHYDROLIPSTATIN;

EID: 84979858784     PISSN: None     EISSN: 21613311     Source Type: Journal    
DOI: 10.1007/s13668-014-0099-x     Document Type: Review
Times cited : (127)

References (35)
  • 1
    • 77951089891 scopus 로고    scopus 로고
    • International Diabetes Federation, Brussels: http://www.idf.org/diabetesatlas
    • International Diabetes Federation. IDF Diabetes Atlas. 6th ed. Brussels: International Diabetes Federation; 2013. http://www.idf.org/diabetesatlas.
    • (2013) IDF Diabetes Atlas
    • International Diabetes Federation1
  • 2
    • 84856487711 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
    • PID: 22253363
    • Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012;307:491–7.
    • (2012) JAMA , vol.307 , pp. 491-497
    • Flegal, K.M.1    Carroll, M.D.2    Kit, B.K.3    Ogden, C.L.4
  • 3
    • 64649083354 scopus 로고    scopus 로고
    • The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis
    • PID: 19320986
    • Guh DP, Zhang W, Bansback N, et al. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88. doi:10.1186/1471-2458-9-88.
    • (2009) BMC Public Health , vol.9 , pp. 88
    • Guh, D.P.1    Zhang, W.2    Bansback, N.3
  • 5
    • 77953821528 scopus 로고    scopus 로고
    • Diabetes fasting glucose concentration and risk of vascular disease: a collaborative metaanalysis of 102 prospective studies
    • Emerging Risk Factor Collaboration. Diabetes fasting glucose concentration and risk of vascular disease: a collaborative metaanalysis of 102 prospective studies. Lancet. 2010;375:2215–22.
    • (2010) Lancet , vol.375 , pp. 2215-2222
    • Emerging Risk Factor Collaboration1
  • 7
    • 84880323061 scopus 로고    scopus 로고
    • Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
    • This is the final results paper with the weight, fitness, and cardiovascular outcomes
    • The Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. NEJM. 2013;369:145–54. This is the final results paper with the weight, fitness, and cardiovascular outcomes.
    • (2013) NEJM , vol.369 , pp. 145-154
    • The Look AHEAD Research Group1
  • 8
    • 84906706277 scopus 로고    scopus 로고
    • Impact of an intensive lifestyle intervention on use and cost of medical services amont overweight and obese adults with type 2 diabetes: the Actsion for Health in Diabetes
    • PID: 25147253
    • Espeland MA, Glick HA, Bertoni A, for the Look AHEAD Research Group, et al. Impact of an intensive lifestyle intervention on use and cost of medical services amont overweight and obese adults with type 2 diabetes: the Actsion for Health in Diabetes. Diabetes Care. 2014;37:2548–56.
    • (2014) Diabetes Care , vol.37 , pp. 2548-2556
    • Espeland, M.A.1    Glick, H.A.2    Bertoni, A.3    for the Look AHEAD Research Group4
  • 9
    • 1642410185 scopus 로고    scopus 로고
    • Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes
    • This explains the design of the study
    • Look AHEAD Research Group. Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Con Clin Trials. 2003;24:610–28. This explains the design of the study.
    • (2003) Con Clin Trials , vol.24 , pp. 610-628
    • Look AHEAD Research Group1
  • 10
    • 33845431986 scopus 로고    scopus 로고
    • Baseline characteristics of the randomized cohort from the Look AHEAD (action for Health in Diabetes) study
    • PID: 17160917
    • Look AHEAD Research Group, Bray G, Gregg E, Haffner S, et al. Baseline characteristics of the randomized cohort from the Look AHEAD (action for Health in Diabetes) study. Diab Vasc Dis Res. 2006;3:202–15.
    • (2006) Diab Vasc Dis Res , vol.3 , pp. 202-215
    • Look AHEAD Research Group1    Bray, G.2    Gregg, E.3    Haffner, S.4
  • 11
    • 33845459014 scopus 로고    scopus 로고
    • The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it
    • PID: 16855180, This gives a description of the intensive intervention in the trial
    • Wadden TA, Smith West D, Delahanty LM, Jakicic JM, Rejeski J, Berkowitz KL, et al. The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Obesity. 2006;14(5):737–52. This gives a description of the intensive intervention in the trial.
    • (2006) Obesity , vol.14 , Issue.5 , pp. 737-752
    • Wadden, T.A.1    Smith West, D.2    Delahanty, L.M.3    Jakicic, J.M.4    Rejeski, J.5    Berkowitz, K.L.6
  • 12
    • 34249864128 scopus 로고    scopus 로고
    • Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD trial
    • PID: 17363746, Pi-Sunyer
    • The Look AHEAD Research Group, Pi-Sunyer, et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD trial. Diabetes Care. 2007;30:1374–83.
    • (2007) Diabetes Care , vol.30 , pp. 1374-1383
    • The Look AHEAD Research Group1
  • 13
    • 62349104344 scopus 로고    scopus 로고
    • Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD study
    • COI: 1:STN:280:DC%2BD1M3gs1ylsw%3D%3D
    • Jakicic JM, Jaramillo SA, Balasubramanyam A, et al. Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD study. Int J Obes (Lond). 2009;33:305–16.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 305-316
    • Jakicic, J.M.1    Jaramillo, S.A.2    Balasubramanyam, A.3
  • 15
    • 77957690115 scopus 로고    scopus 로고
    • Long term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    • The Look AHEAD Research Group. Long term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Int Med. 2010;170:1566–75.
    • (2010) Arch Int Med , vol.170 , pp. 1566-1575
    • The Look AHEAD Research Group1
  • 16
    • 84892172318 scopus 로고    scopus 로고
    • Eight-year weight losses with an intensive lifestyle intervention: the Look AHEAD Study
    • The Look AHEAD Research Group. Eight-year weight losses with an intensive lifestyle intervention: the Look AHEAD Study. Obesity. 2014;22:5–13.
    • (2014) Obesity , vol.22 , pp. 5-13
    • The Look AHEAD Research Group1
  • 17
    • 70349776890 scopus 로고    scopus 로고
    • A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes, the Sleep AHEAD study
    • Foster GD, Borradaile KE, Sanders MH, et al. A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes, the Sleep AHEAD study. Arch Int Med. 2009;169:1619–26.
    • (2009) Arch Int Med , vol.169 , pp. 1619-1626
    • Foster, G.D.1    Borradaile, K.E.2    Sanders, M.H.3
  • 18
    • 84877119614 scopus 로고    scopus 로고
    • Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes
    • PID: 23633746
    • Kuna ST, Reboussin DM, Borradaile KE, Sanders MH, Millman RP, Zammit G, et al. Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes. Sleep. 2013;36:641–9.
    • (2013) Sleep , vol.36 , pp. 641-649
    • Kuna, S.T.1    Reboussin, D.M.2    Borradaile, K.E.3    Sanders, M.H.4    Millman, R.P.5    Zammit, G.6
  • 19
    • 78149283488 scopus 로고    scopus 로고
    • Effect of a 12-month intensive lifestyle intervention on hepatic steatosisin adults with type 2 diabetes
    • Lazo M, Solga S, Horska A, et al. Effect of a 12-month intensive lifestyle intervention on hepatic steatosisin adults with type 2 diabetes. Diab Care. 2010;33:2156–63.
    • (2010) Diab Care , vol.33 , pp. 2156-2163
    • Lazo, M.1    Solga, S.2    Horska, A.3
  • 20
    • 84859217994 scopus 로고    scopus 로고
    • One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study
    • Faulconbridge L, Wadden T, Rubin R, et al. One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring). 2012;20:783–93.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 783-793
    • Faulconbridge, L.1    Wadden, T.2    Rubin, R.3
  • 21
    • 84901461368 scopus 로고    scopus 로고
    • The Look AHEAD trial
    • The Look AHEAD Research Group. Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: The Look AHEAD trial. Diabetes Care 2014;37:1544–1553.
    • (2014) Diabetes Care , vol.37 , pp. 1544-1553
  • 22
    • 84862807230 scopus 로고    scopus 로고
    • Weight loss prevents urinary incontinence in women with type 2 diabetes: Results from the Look AHEAD Trial
    • PID: 22264468
    • Phelan S, Kanaya A, SubakL, et al. Weight loss prevents urinary incontinence in women with type 2 diabetes: Results from the Look AHEAD Trial. J Urol. 2012;187:939–44.
    • (2012) J Urol , vol.187 , pp. 939-944
    • Phelan, S.1    Kanaya, A.2    Subak, L.3
  • 23
    • 84921437510 scopus 로고    scopus 로고
    • Effect of a long-term behavioral weight loss intervention on nephropathy in overweigth or obese adults with type 2 diabetes: the Look AHEAD randomised clinical trial
    • The Look AHEAD Research Group. Effect of a long-term behavioral weight loss intervention on nephropathy in overweigth or obese adults with type 2 diabetes: the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2014. doi:10.1016/S2213-8587(14)70156-1.
    • (2014) Lancet Diabetes Endocrinol
  • 24
    • 77956071596 scopus 로고    scopus 로고
    • Effect of the Look AHEAD study intervention on medication use and related cost to treat cardiovascular disease risk factors in individuals with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXotFKiu7o%3D, PID: 20332353
    • Redmon B, Bertoni A, Connely S, et al. Effect of the Look AHEAD study intervention on medication use and related cost to treat cardiovascular disease risk factors in individuals with type 2 diabetes. Diabetes Care. 2010;33:1153–8.
    • (2010) Diabetes Care , vol.33 , pp. 1153-1158
    • Redmon, B.1    Bertoni, A.2    Connely, S.3
  • 25
    • 84876813863 scopus 로고    scopus 로고
    • Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: the Look AHEAD Trial
    • COI: 1:CAS:528:DC%2BC3sXnslWrsb4%3D
    • Jakicic JM, Egan CM, Fabricatore AN, Gaussoin SA, Glasser SP, Hesson LA, et al. Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: the Look AHEAD Trial. Diab Care. 2013;36:1297–303.
    • (2013) Diab Care , vol.36 , pp. 1297-1303
    • Jakicic, J.M.1    Egan, C.M.2    Fabricatore, A.N.3    Gaussoin, S.A.4    Glasser, S.P.5    Hesson, L.A.6
  • 26
    • 58849095749 scopus 로고    scopus 로고
    • Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes
    • Williamson D, Rejeski J, Lang WA, et al. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Int Med. 2009;169:163–71.
    • (2009) Arch Int Med , vol.169 , pp. 163-171
    • Williamson, D.1    Rejeski, J.2    Lang, W.A.3
  • 27
    • 78650679300 scopus 로고    scopus 로고
    • Intensive lifestyle intervention improves physical function among obese adults with knee pain: Findings from the Look AHEAD Trial
    • Foy C, Lewis B, Hairston K, et al. Intensive lifestyle intervention improves physical function among obese adults with knee pain: Findings from the Look AHEAD Trial. Obesity (Silver Spring). 2011;19:83–93.
    • (2011) Obesity (Silver Spring) , vol.19 , pp. 83-93
    • Foy, C.1    Lewis, B.2    Hairston, K.3
  • 28
    • 84891882105 scopus 로고    scopus 로고
    • Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: results from an ancillary Look AHEAD study
    • PID: 23757437
    • Wing RR, Bond DS, Gendrano 3rd IN, et al. Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: results from an ancillary Look AHEAD study. Diabetes Care. 2013;36:2937–44.
    • (2013) Diabetes Care , vol.36 , pp. 2937-2944
    • Wing, R.R.1    Bond, D.S.2    Gendrano, I.N.3
  • 29
    • 84879342248 scopus 로고    scopus 로고
    • Lifestyle intervention and/or statins for the reduction of C-reactive protein in diabetes: from the Look AHEAD Study
    • COI: 1:CAS:528:DC%2BC3sXpvFaksLk%3D
    • Belalcazar M, Haffner S, Lang W, et al. Lifestyle intervention and/or statins for the reduction of C-reactive protein in diabetes: from the Look AHEAD Study. Obesity (Silver Spring). 2013;21:944–50.
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 944-950
    • Belalcazar, M.1    Haffner, S.2    Lang, W.3
  • 30
    • 84857079880 scopus 로고    scopus 로고
    • Midcourse correction to a clinical trial when the event rate is underestimated.: the LookAHEAD (Action for Health in Diabetes) Study
    • PID: 22334468
    • Brancati FL et al. Midcourse correction to a clinical trial when the event rate is underestimated.: the LookAHEAD (Action for Health in Diabetes) Study. Clin Trials. 2012;9:113–24.
    • (2012) Clin Trials , vol.9 , pp. 113-124
    • Brancati, F.L.1
  • 31
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of ype 2 diabetes with lifestyle intervention or metformin
    • Diabetes Prevention Program Research Group. Reduction in the incidence of ype 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393–403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Diabetes Prevention Program Research Group1
  • 32
    • 83055166908 scopus 로고    scopus 로고
    • Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial
    • PID: 21836103
    • Unick JL, Beavers D, Jakicic JM, Kitabchi AE, Knowler WC, Wadded TA, et al. Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial. Diabetes Care. 2011;34:2152–7.
    • (2011) Diabetes Care , vol.34 , pp. 2152-2157
    • Unick, J.L.1    Beavers, D.2    Jakicic, J.M.3    Kitabchi, A.E.4    Knowler, W.C.5    Wadded, T.A.6
  • 33
    • 33845459014 scopus 로고    scopus 로고
    • The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it
    • [Erratum, Obesity (Silver Spring) 2007; 15: 1339.]
    • Look AHEAD Research Group, Wadden TA, West DS. The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring). 2006;14:737–52 [Erratum, Obesity (Silver Spring) 2007; 15: 1339.].
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 737-752
    • Look AHEAD Research Group1    Wadden, T.A.2    West, D.S.3
  • 34
    • 84871314601 scopus 로고    scopus 로고
    • Association of an intensive lifestyle intervention with remission of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXkt1ChtA%3D%3D, PID: 23288372
    • Gregg EW, Chen H, Wagenknecht LE, et al. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA. 2012;308:2489–98.
    • (2012) JAMA , vol.308 , pp. 2489-2498
    • Gregg, E.W.1    Chen, H.2    Wagenknecht, L.E.3
  • 35
    • 0025367559 scopus 로고
    • Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
    • COI: 1:STN:280:DyaK3c3ltVyhsQ%3D%3D, PID: 2338751
    • Haffner SM, Stern MP, Hazuda HP, et al. Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA. 1990;263:2893–8.
    • (1990) JAMA , vol.263 , pp. 2893-2898
    • Haffner, S.M.1    Stern, M.P.2    Hazuda, H.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.