Molecular characterization of Clostridium difficile Isolates in China from 2010 to 2015

Frontiers in Microbiology

Volumn 9, Issue APR, 2018, Pages

  Liu, Xiao shu ^a   Li, Wen ge ^a   Zhang, Wen zhu ^a   Wu, Yuan ^a   Lu, Jin xing ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Clostridium difficile; MLST; Molecular characterization; PCR ribotyping; Toxin genes profile

Indexed keywords

BACTERIAL TOXIN; CYTOTOXIN; ENTEROTOXIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CHILD; CHINA; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DIARRHEA; DNA ISOLATION; FEMALE; GENETIC ANALYSIS; GEOGRAPHIC DISTRIBUTION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MOLECULAR TYPING; MULTILOCUS SEQUENCE TYPING; NEWBORN; PEPTOCLOSTRIDIUM DIFFICILE; PHYLOGENY; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; RIBOTYPING; VERY ELDERLY;

EID: 85046688593     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2018.00845     Document Type: Article

References (41)

1. Antunes, A., and Dupuy, B. (2010). Molecular methods to study transcriptional regulation of Clostridium difficile toxin genes. Methods Mol. Biol. 646, 93-115. doi: 10.1007/978-1-60327-365-7_7
2. Bauer, M. P., Notermans, D. W., van Benthem, B. H., Brazier, J. S., Wilcox, M. H., Rupnik, M., et al. (2011). Clostridium difficile infection in Europe: a hospital-based survey. Lancet 377, 63-73. doi: 10.1016/S0140-6736(10)61266-4
3. Cairns, M. D., Preston, M. D., Hall, C. L., Gerding, D. N., Hawkey, P. M., Kato, H., et al. (2017). Comparative genome analysis and global phylogeny of the toxin variant Clostridium difficile PCR ribotype 017 reveals the evolution of two independent sublineages. J. Clin. Microbiol. 55, 865-876. doi: 10.1128/JCM.01296-16
4. Carter, G. P., Douce, G. R., Govind, R., Howarth, P. M., Mackin, K. E., Spencer, J., et al. (2011). The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile. PLoS Pathog. 7:e1002317. doi: 10.1371/journal.ppat.1002317
5. Cheng, J. W., Xiao, M., Kudinha, T., Kong, F., Xu, Z. P., Sun, L. Y., et al. (2016). Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolates from a university teaching hospital in China. Front. Microbiol. 7:1621. doi: 10.3389/fmicb.2016.01621
6. Cohen, S. H., Gerding, D. N., Johnson, S., Kelly, C. P., Loo, V. G., McDonald, L. C., et al. (2010). Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect. Control Hosp. Epidemiol. 31, 431-455. doi: 10.1086/651706
7. Cohen, S. H., Tang, Y. J., and Silva, J. J. (2000). Analysis of the pathogenicity locus in Clostridium difficile strains. J. Infect. Dis. 181, 659-663. doi: 10.1086/315248
8. Collins, D. A., Hawkey, P. M., and Riley, T. V. (2013). Epidemiology of Clostridium difficile infection in Asia. Antimicrob. Resist. Infect. Control 2:21. doi: 10.1186/2047-2994-2-21
9. Dingle, K. E., Elliott, B., Robinson, E., Griffiths, D., Eyre, D. W., Stoesser, N., et al. (2014). Evolutionary history of the Clostridium difficile pathogenicity locus. Genome Biol. Evol. 6, 36-52. doi: 10.1093/gbe/evt204
10. Dingle, K. E., Griffiths, D., Didelot, X., Evans, J., Vaughan, A., Kachrimanidou, M., et al. (2011). Clinical Clostridium difficile: clonality and pathogenicity locus diversity. PLoS One 6:e19993. doi: 10.1371/journal.pone.0019993
11. Freeman, J., Bauer, M. P., Baines, S. D., Corver, J., Fawley, W. N., Goorhuis, B., et al. (2010). The changing epidemiology of Clostridium difficile infections. Clin. Microbiol. Rev. 23, 529-549. doi: 10.1128/CMR.00082-09
12. Gao, Q., Wu, S., Huang, H., Ni, Y., Chen, Y., Hu, Y., et al. (2016). Toxin profiles, PCR ribotypes and resistance patterns of Clostridium difficile: a multicentre study in China, 2012-2013. Int. J. Antimicrob. Agents 48, 736-739. doi: 10.1016/j.ijantimicag.2016.09.009
13. Goorhuis, A., Bakker, D., Corver, J., Debast, S. B., Harmanus, C., Notermans, D. W., et al. (2008). Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clin. Infect. Dis. 47, 1162-1170. doi: 10.1086/592257
14. Gravel, D., Miller, M., Simor, A., Taylor, G., Gardam, M., McGeer, A., et al. (2009). Health care-associated Clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian nosocomial infection surveillance program study. Clin. Infect. Dis. 48, 568-576. doi: 10.1086/596703
15. Griffiths, D., Fawley, W., Kachrimanidou, M., Bowden, R., Crook, D. W., Fung, R., et al. (2010). Multilocus sequence typing of Clostridium difficile. J. Clin. Microbiol. 48, 770-778. doi: 10.1128/JCM.01796-09
16. Huang, H., Shi, W. U., Zhu, D., Jufang, W. U., Wang, M., and Zhang, Y. (2011). Antimicrobial resistance in 188 clinical isolates of Clostridium difficile. Chin. J. Infect. Chemother. 11, 1-5
17. Janezic, S., and Rupnik, M. (2015). Genomic diversity of Clostridium difficile strains. Res. Microbiol. 166, 353-360. doi: 10.1016/j.resmic.2015.02.002
18. Jin, D., Luo, Y., Huang, C., Cai, J., Ye, J., Zheng, Y., et al. (2017). Molecular epidemiology of Clostridium difficile infection in hospitalized patients in eastern China. J. Clin. Microbiol. 55, 801-810. doi: 10.1128/JCM.01898-16
19. Kato, H., Kato, N., Watanabe, K., Iwai, N., Nakamura, H., Yamamoto, T., et al. (1998). Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J. Clin. Microbiol. 36, 2178-2182
20. Kato, N., Ou, C. Y., Kato, H., Bartley, S. L., Brown, V. K., Dowell, V. R., et al. (1991). Identification of toxigenic Clostridium difficile by the polymerase chain reaction. J. Clin. Microbiol. 29, 33-37
21. Knetsch, C. W., Lawley, T. D., Hensgens, M. P., Corver, J., Wilcox, M. W., and Kuijper, E. J. (2013). Current application and future perspectives of molecular typing methods to study Clostridium difficile infections. Euro Surveill. 18:20381. doi: 10.2807/ese.18.04.20381-en
22. Knetsch, C. W., Terveer, E. M., Lauber, C., Gorbalenya, A. E., Harmanus, C., Kuijper, E. J., et al. (2012). Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages. Infect. Genet. Evol. 12, 1577-1585. doi: 10.1016/j.meegid.2012.06.003
23. Knight, D. R., Elliott, B., Chang, B. J., Perkins, T. T., and Riley, T. V. (2015). Diversity and evolution in the genome of Clostridium difficile. Clin. Microbiol. Rev. 28, 721-741. doi: 10.1128/CMR.00127-14
24. Kuijper, E. J., Barbut, F., Brazier, J. S., Kleinkauf, N., Eckmanns, T., Lambert, M. L., et al. (2008). Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. Euro. Surveill. 13:18942
25. Kuijper, E. J., de Weerdt, J., Kato, H., Kato, N., van Dam, A. P., van der Vorm, E. R., et al. (2001). Nosocomial outbreak of Clostridium difficile-associated diarrhoea due to a clindamycin-resistant enterotoxin A-negative strain. Eur. J. Clin. Microbiol. Infect. Dis. 20, 528-534. doi: 10.1007/s100960100550
26. Lemee, L., Dhalluin, A., Testelin, S., Mattrat, M. A., Maillard, K., Lemeland, J. F., et al. (2004). Multiplex PCR targeting tpi (triose phosphate isomerase), tcdA (Toxin A), and tcdB (Toxin B) genes for toxigenic culture of Clostridium difficile. J. Clin. Microbiol. 42, 5710-5714. doi: 10.1128/JCM.42.12.5710-5714.2004
27. Lessa, F. C., Gould, C. V., and McDonald, L. C. (2012). Current status of Clostridium difficile infection epidemiology. Clin. Infect. Dis. 55, 65-70. doi: 10.1093/cid/cis319
28. Liao, F., Li, W., Gu, W., Zhang, W., Liu, X., Fu, X., et al. (2018). A retrospective study of community-acquired Clostridium difficile infection in southwest China. Sci. Rep. 8:3992. doi: 10.1038/s41598-018-21762-7
29. Lin, Y. C., Huang, Y. T., Tsai, P.-J., Lee, T. F., Lee, N. Y., Liao, C. H., et al. (2011). Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in taiwan. Antimicrob. Agents Chemother. 55, 1701-1705. doi: 10.1128/AAC.01440-10
30. O'Neill, G. L., Brazier, J. S., and Duerden, B. I. (1996). Modification of a PCR ribotyping method for application as a routine typing scheme for Clostridium difficile. Anaerobe 2, 205-209. doi: 10.1006/anae.1996.0028
31. Rineh, A., Kelso, M. J., Vatansever, F., Tegos, G. P., and Hamblin, M. R. (2014). Clostridium difficile infection: molecular pathogenesis and novel therapeutics. Exp. Rev. Anti Infect. Ther. 12, 131-150. doi: 10.1586/14787210.2014.866515
32. Rupnik, M., Widmer, A., Zimmermann, O., Eckert, C., and Barbut, F. (2008). Clostridium difficile toxinotype V, ribotype 078, in animals and humans. J. Clin. Microbiol. 46:2146. doi: 10.1128/JCM.00598-08
33. Rupnik, M., Wilcox, M. H., and Gerding, D. N. (2009). Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat. Rev. Microbiol. 7, 526-536. doi: 10.1038/nrmicro2164
34. Spigaglia, P., and Mastrantonio, P. (2002). Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile clinical isolates. J. Clin. Microbiol. 40, 3470-3475. doi: 10.1128/JCM.40.9.3470-3475.2002
35. Stabler, R. A., Dawson, L. F., Valiente, E., Cairns, M. D., Martin, M. J., Donahue, E. H., et al. (2012). Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations. PLoS One 7:e31559. doi: 10.1371/journal.pone.0031559
36. Stubbs, S., Rupnik, M., Gibert, M., Brazier, J., Duerden, B., and Popoff, M. (2000). Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile. FEMS Microbiol. Lett. 186, 307-312. doi: 10.1111/j.1574-6968.2000.tb09122.x
37. Sun, X., and Hirota, S. A. (2015). The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection. Mol. Immunol. 63, 193-202. doi: 10.1016/j.molimm.2014.09.005
38. Tang, C., Cui, L., Xu, Y., Xie, L., Sun, P., Liu, C., et al. (2016). The incidence and drug resistance of Clostridium difficile infection in Mainland China: a systematic review and meta-analysis. Sci. Rep. 6:37865. doi: 10.1038/srep37865
39. Tian, T. T., Zhao, J. H., Yang, J., Qiang, C. X., Li, Z. R., Chen, J., et al. (2016). Molecular characterization of Clostridium difficile isolates from human subjects and the environment. PLoS One 11:e0151964. doi: 10.1371/journal.pone.0151964
40. Voth, D. E., and Ballard, J. D. (2005). Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18, 247-263. doi: 10.1128/CMR.18.2.247-263.2005
41. Yan, Q., Zhang, J., Chen, C., Zhou, H., Du, P., Cui, Z., et al. (2013). Multilocus sequence typing (MLST) analysis of 104 Clostridium difficile strains isolated from China. Epidemiol. Infect. 141, 195-199. doi: 10.1017/S0950268812000453