Levels of selected analytes in the emissions of “heat not burn” tobacco products that are relevant to assess human health risks

Archives of Toxicology

Volumn 92, Issue 6, 2018, Pages 2145-2149

  Mallock, Nadja ^a   Böss, Lisa ^a   Burk, Robert ^b   Danziger, Martin ^b   Welsch, Tanja ^b   Hahn, Harald ^b   Trieu, Hai Linh ^b   Hahn, Jürgen ^b   Pieper, Elke ^a   Henkler Stephani, Frank ^a   Hutzler, Christoph ^a   Luch, Andreas ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^b Official Chemical and Veterinary Surveillance Institute Sigmaringen   (Germany)

Author keywords

Carcinogens; Heat not burn; Nicotine; Non cigarette tobacco products; Smoke chemistry

Indexed keywords

1,3 BUTADIENE; ACETALDEHYDE; ACROLEIN; BENZENE; CARCINOGEN; CROTONALDEHYDE; FORMALDEHYDE; ISOPRENE; NICOTINE; STYRENE; TOBACCO SMOKE; TOLUENE; WATER; VOLATILE ORGANIC COMPOUND;

CANADA; CIGARETTE SMOKING; EXPOSURE; HEALTH HAZARD; HEALTH IMPACT ASSESSMENT; HEAT NOT BURN DEVICE; HIGH RISK POPULATION; HUMAN; LETTER; MONITORING; PARTICULATE MATTER; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; REPRODUCIBILITY; RISK ASSESSMENT; SMOKING DEVICE; STANDARD; TOBACCO CONSUMPTION; AIR POLLUTANT; ANALYSIS; HEAT; SMOKE; TOBACCO;

AIR POLLUTANTS; CANADA; HOT TEMPERATURE; NICOTINE; PARTICULATE MATTER; RISK ASSESSMENT; SMOKE; TOBACCO PRODUCTS; VOLATILE ORGANIC COMPOUNDS;

EID: 85046407676     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-018-2215-y     Document Type: Letter

References (28)

1. Auer R, Concha-Lozano N, Jacot-Sadowski I, Cornuz J, Berthet A (2017) Heat-not-burn tobacco cigarettes: smoke by any other name. JAMA Intern Med 177(7):1050–1052. 10.1001/jamainternmed.2017.1419
2. Baker RR, Massey ED, Smith G (2004) An overview of the effects of tobacco ingredients on smoke chemistry and toxicity. Food Chem Toxicol 42 (Suppl):S53–S83 10.1016/j.fct.2004.01.001
3. Bekki K, Inaba Y, Uchiyama S, Kunugita N (2017) Comparison of chemicals in mainstream smoke in heat-not-burn tobacco and combustion cigarettes. J UOEH 39(3):201–207. 10.7888/juoeh.39.201
4. Caputi TL (2016) Industry watch: heat-not-burn tobacco products are about to reach their boiling point. Tob Control 26(5):609–610. 10.1136/tobaccocontrol-2016-053264
5. Counts ME, Morton MJ, Laffoon SW, Cox RH, Lipowicz PJ (2005) Smoke composition and predicting relationships for international commercial cigarettes smoked with three machine-smoking conditions. Regul Toxicol Pharmacol 41(3):185–227. 10.1016/j.yrtph.2004.12.002
6. EU (2014) Directive 2014/40/EU of the European Parliament and of the Council of 3 April 2014 on the approximation of the laws, regulation and administrative provisions of the member states concerning the manufacture, presentation and sale of tobacco and related products and repealing Directive 2001/37/EC
7. Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K (2017) Nicotine delivery to the aerosol of a heat-not-burn tobacco product: comparison with a tobacco cigarette and e-cigarettes. Nicotine Tob Res. 10.1093/ntr/ntx138
8. Food and Drug Administration (2018) FDA briefing document: January 24–25, 2018 TPSAC meeting. https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/TobaccoProductsScientificAdvisoryCommittee/UCM593109.pdf. Accessed Mar 2018
9. Fowles J, Dybing E (2003) Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob Control 12(4):424–430. 10.1136/tc.12.4.424
10. GBD 2015 Tobacco Collaborators (2017) Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015. Lancet 389(10082):1885–1906 10.1016/S0140-6736(17)30819-X
11. Ghosh D, Jeannet C (2014) An improved Cambridge filter pad extraction methodology to obtain more accurate water and “tar” values: in situ Cambridge filter pad extraction methodology. Beitr Tabakforschung/Int Contrib Tob Res 26(2):38–49. 10.2478/cttr-2014-0008
12. Health Canada (2000) Tobacco reporting regulations, SOR/2000 – 273
13. Henkler F, Luch A (2015) Alternativen zu Zigaretten und herkömmlichen Tabakerzeugnissen—Ein kurzer historischer und aktueller Überblick. Rundschau für Fleischhygiene Lebensmittelüberwachung 67(1):39–41
14. Hoffmann D, Hoffmann I, El-Bayoumy K (2001) The less harmful cigarette: A controversial issue. A tribute to Ernst L. Wynder. Chem Res Toxicol 14(7):767–790
15. Inoue-Choi M, Hartge P, Liao LM, Caporaso N, Freedman ND (2018) Association between long-term low-intensity cigarette smoking and incidence of smoking-related cancer in the national institutes of health-AARP cohort. Int J Cancer 142(2):271–280. 10.1002/ijc.31059
16. ISO 3308 (2012) Routine analytical cigarette-smoking machine - Definitions and standard conditions. International Organisation for Standardisation, Geneva
17. ISO 4387 (2000) Cigarettes—determination of total and nicotine-free dry particulate matter using a routine analytical smoking machine. International Organisation for Standardisation, Geneva
18. Law MR, Morris JK, Watt HC, Wald NJ (1997) The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer. Br J Cancer 75(11):1690–1693
19. Li X, Luo Y, Jiang X et al (2018) Chemical analysis and simulated pyrolysis of tobacco heating system 2.2 compared to conventional cigarettes. Nicotine Tob Res. 10.1093/ntr/nty005
20. Muramatsu M (2005) An approach to modeling a burning cigarette. Beitr Tabakforschung/Int Contrib Tob Res 21(5):286–293. 10.2478/cttr-2013-0795
21. Pesch B, Kendzia B, Gustavsson P et al (2012) Cigarette smoking and lung cancer—relative risk estimates for the major histological types from a pooled analysis of case–control studies. Int J Cancer 131(5):1210–1219. 10.1002/ijc.27339
22. Rodgman A, Green CR (2003) toxic chemicals in cigarette mainstream smoke—hazard and hoopla. Beitr Tabakforschung/Int Contrib Tob Res 20(8):481–545. 10.2478/cttr-2013-0764
23. Savareear B, Lizak R, Brokl M, Wright C, Liu C, Focant JF (2017) Headspace solid-phase microextraction coupled to comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the analysis of aerosol from tobacco heating product. J Chromatogr A 1520:135–142. 10.1016/j.chroma.2017.09.014
24. Schaller JP, Keller D, Poget L et al (2016) Evaluation of the tobacco heating system 2.2. Part 2: chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol. Regul Toxicol Pharmacol 81(Suppl 2):S27-S47. 10.1016/j.yrtph.2016.10.001
25. Stephens WE (2018) Comparing the cancer potencies of emissions from vapourised nicotine products including e-cigarettes with those of tobacco smoke. Tob Control 27:10–17. 10.1136/tobaccocontrol-2017-053808
26. Talhout R, Schulz T, Florek E, van Benthem J, Wester P, Opperhuizen A (2011) Hazardous compounds in tobacco smoke. Int J Environ Res Public Health 8(2):613–628. 10.3390/ijerph8020613
27. World Health Organization (2014) Work in progress in relation to Articles 9 and 10 of the WHO FCTC. http://apps.who.int/gb/fctc/PDF/cop6/FCTC_COP6_14-en.pdf. Accessed Jan 2018
28. World Health Organization (2018) Framework convention on tobacco control. http://www.who.int/fctc/en/. Accessed Jan 2018