Evolution of high-level resistance during low-level antibiotic exposure

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Wistrand Yuen, Erik ^a   Knopp, Michael ^a   Hjort, Karin ^a   Koskiniemi, Sanna ^a   Berg, Otto G ^a   Andersson, Dan I ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; RIBOSOME RNA; STREPTOMYCIN; TRANSFER RNA; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; RIBOSOMAL PROTEIN S12; RIBOSOME PROTEIN;

ANTIBIOTICS; BACTERIUM; ENZYME; ENZYME ACTIVITY; MUTATION; REDUCTION; RNA;

AADA GENE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; CONTROLLED STUDY; CYOB GENE; DRUG EXPOSURE; FRAMESHIFT MUTATION; GIDB GENE; LOSS OF FUNCTION MUTATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; MUTATION RATE; NONHUMAN; NUOG GENE; OPERON; POPULATION SIZE; PROTON MOTIVE FORCE; RESPIRATORY CHAIN; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; TRKH GENE; UPREGULATION; WHOLE GENOME SEQUENCING; ZNUA GENE; BACTERIAL GENOME; BIOLOGICAL MODEL; DOSE RESPONSE; DRUG EFFECT; GENETIC SELECTION; GENETICS; MICROBIAL SENSITIVITY TEST; MUTATION; PHYSIOLOGY; SALMONELLA ENTERICA;

SALMONELLA ENTERICA;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; EVOLUTION, MOLECULAR; GENOME, BACTERIAL; MICROBIAL SENSITIVITY TESTS; MODELS, GENETIC; MUTATION; RIBOSOMAL PROTEINS; SALMONELLA ENTERICA; SELECTION, GENETIC; STREPTOMYCIN; WHOLE GENOME SEQUENCING;

EID: 85046139949     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-04059-1     Document Type: Article

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