Myristic acid induces proteomic and secretomic changes associated with steatosis, cytoskeleton remodeling, endoplasmic reticulum stress, protein turnover and exosome release in HepG2 cells

Journal of Proteomics

Volumn 181, Issue , 2018, Pages 118-130

  Speziali, Giulia ^a   Liesinger, Laura ^b,c   Gindlhuber, Juergen ^b,c   Leopold, Christina ^b   Pucher, Bettina ^b,c,d   Brandi, Jessica ^a   Castagna, Annalisa ^e   Tomin, Tamara ^b,c   Krenn, Petra ^b,c   Thallinger, Gerhard G ^c,d   Olivieri, Oliviero ^e   Martinelli, Nicola ^e   Kratky, Dagmar ^b,c   Schittmayer, Matthias ^b,c   Birner Gruenberger, Ruth ^b,c   Cecconi, Daniela ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c BIOTECHMED GRAZ   (Austria)

^d GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^e UNIVERSITY OF VERONA   (Italy)

Author keywords

HepG2 cells; Myristic acid; Primary murine hepatocytes; Proteome; Secretome

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; ADIPOPHILIN; ALPHA 2 MACROGLOBULIN; APOLIPOPROTEIN E; ASIALOGLYCOPROTEIN RECEPTOR; CASEIN KINASE II; CD147 ANTIGEN; CONDENSIN; CYTOCHROME C OXIDASE; DYNAMIN II; FAT DROPLET; FATTY ACID; FIBRINOGEN; INITIATION FACTOR 4E; INTERCELLULAR ADHESION MOLECULE 1; LONG CHAIN 3 HYDROXYACYL COENZYME A DEHYDROGENASE; MARCKS PROTEIN; MEMBRANE ANTIGEN; MYRISTIC ACID; PROLYL ENDOPEPTIDASE; RETINOL BINDING PROTEIN 4; SIGNAL RECOGNITION PARTICLE; URIDINE DIPHOSPHATE GLUCOSE DEHYDROGENASE; PROTEOME;

ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR DISEASE; CELL SELECTION; CONTROLLED STUDY; CYTOSKELETON; ENDOPLASMIC RETICULUM STRESS; EXOSOME; GENE ONTOLOGY; HEP-G2 CELL LINE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SECRETION; PROTEOMICS; STEATOSIS; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; FATTY LIVER; LIVER; METABOLISM; PATHOLOGY; PROTEIN DEGRADATION;

ANIMALS; CYTOSKELETON; ENDOPLASMIC RETICULUM STRESS; EXOSOMES; FATTY LIVER; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER; MICE; MYRISTIC ACID; PROTEOLYSIS; PROTEOME;

EID: 85045844894     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2018.04.008     Document Type: Article

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