The use of recombinant feline interferon omega therapy as an immune-modulator in cats naturally infected with feline immunodeficiency virus: New perspectives

Veterinary Sciences

Volumn 3, Issue 4, 2016, Pages

  Leal, Rodolfo Oliveira ^a   Gil, Solange ^b  

^a CENTRE HOSPITALIER VÉTÉRINAIRE FRÉGIS   (France)

^b UNIVERSITY OF LISBON   (Portugal)

Author keywords

Feline; Feline immunodeficiency virus; Immune modulation; Interferon therapy; Recombinant feline interferon omega

Indexed keywords

EID: 85045409180     PISSN: None     EISSN: 23067381     Source Type: Journal    
DOI: 10.3390/vetsci3040032     Document Type: Review

References (36)

1. Hartmann, K. Clinical aspects of feline retroviruses: A review. Viruses 2012, 4, 2684-2710
2. Hartmann, K. Clinical aspects of feline immunodeficiency and feline leukemia virus infection. Vet. Immunol. Immunopathol. 2011, 143, 190-201
3. Hartmann, K. Efficacy of antiviral chemotherapy for retrovirus-infected cats: What does the current literature tell us? J. Feline Med. Surg. 2015, 17, 925-939
4. Hartmann, K. Chapter 2: Antiviral and Immmunomodulatory Chemotherapy. In Infectious Diseases of the Dog and Cat; Elsevier: Missouri, MO, USA, 2012; pp. 10-25
5. Sadler, A.J.; Williams, B.R.G. Interferon-inducible antiviral effectors. Nat. Rev. Immunol. 2008, 8, 559-568
6. Sirén, J.; Pirhonen, J.; Julkunen, I.; Matikainen, S. IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29. J. Immunol. 2005, 174, 1932-1937
7. Colonna, M.; Trinchieri, G.; Liu, Y.-J. Plasmacytoid dendritic cells in immunity. Nat. Immunol. 2004, 5, 1219-1226
8. Bracklein, T.; Theise, S.; Metzler, A.; Spiess, B.M.; Richter, M. Activity of feline interferon-omega after ocular or oral administration in cats as indicated by Mx protein expression in conjunctival and white blood cells. Am. J. Vet. Res. 2006, 67, 1025-1032
9. Goodbourn, S.; Didcock, L.; Randall, R.E. Interferons: Cell signalling, immune modulation, antiviral response and virus countermeasures. J. Gen. Virol. 2000, 81, 2341-2364
10. Sandler, N.G.; Bosinger, S.E.; Estes, J.D.; Zhu, R.T.R.; Tharp, G.K.; Boritz, E.; Levin, D.; Wijeyesinghe, S.; Makamdop, K.N.; del Prete, G.Q.; et al. Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature 2014, 511, 601-605
11. Doyle, T.; Goujon, C.; Malim, M.H. HIV-1 and interferons: Who's interfering with whom? Nat. Rev. Microbiol. 2015, 13, 403-413
12. Wang, F.-X.; Huang, J.; Zhang, H.; Ma, X.; Zhang, H. APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells. J. Gen. Virol. 2008, 89, 722-730
13. Michaelis, B.; Levy, J.A. HIV replication can be blocked by recombinant human interferon beta. AIDS Lond. Engl. 1989, 3, 27-31
14. Horton, R.E.; McLaren, P.J.; Fowke, K.; Kimani, J.; Ball, T.B. Cohorts for the study of HIV-1-exposed but uninfected individuals: Benefits and limitations. J. Infect. Dis. 2010, 202, S377-S381
15. Sivro, A.; Su, R.-C.; Plummer, F.A.; Ball, T.B. Interferon responses in HIV infection: From protection to disease. AIDS Rev. 2014, 16, 43-51
16. Azzoni, L.; Foulkes, A.S.; Papasavvas, E.; Mexas, A.M.; Lynn, K.M.; Mounzer, K.; Tebas, P.; Jacobson, J.M.; Frank, I.; Busch, M.P.; et al. Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration. J. Infect. Dis. 2013, 207, 213-222
17. Doménech, A.; Miró, G.; Collado, V.M.; Ballesteros, N.; Sanjosé, L.; Escolar, E.; Martin, S.; Gomez-Lucia, E. Use of recombinant interferon omega in feline retrovirosis: From theory to practice. Vet. Immunol. Immunopathol. 2011, 143, 301-306
18. De Mari, K.; Maynard, L.; Sanquer, A.; Lebreux, B.; Eun, H.-M. Therapeutic effects of recombinant feline interferon-omega on feline leukemia virus (FeLV)-infected and FeLV/feline immunodeficiency virus (FIV)-coinfected symptomatic cats. J. Vet. Intern. Med. Am. Coll. Vet. Intern. Med. 2004, 18, 477-482
19. Tompkins, W.A. Immunomodulation and therapeutic effects of the oral use of interferon-alpha: Mechanism of action. J. Interferon Cytokine Res. 1999, 19, 817-828
20. Fulton, R.W.; Burge, L.J. Susceptibility of feline herpesvirus 1 and a feline calicivirus to feline interferon and recombinant human leukocyte interferons. Antimicrob. Agents Chemother. 1985, 28, 698-699
21. Pedretti, E.; Passeri, B.; Amadori, M.; Isola, P.; di Pede, P.; Telera, A.; Vescovini, R.; Quintavalla, F.; Pistello, M. Low-dose interferon-alpha treatment for feline immunodeficiency virus infection. Vet. Immunol. Immunopathol. 2006, 109, 245-254
22. Weiss, R.C.; Oostrom-Ram, T. Inhibitory effects of ribavirin alone or combined with human alpha interferon on feline infectious peritonitis virus replication in vitro. Vet. Microbiol. 1989, 20, 255-265
23. Zeidner, N.S.; Myles, M.H.; Mathiason-DuBard, C.K.; Dreitz, M.J.; Mullins, J.I.; Hoover, E.A. Alpha interferon (2b) in combination with zidovudine for the treatment of presymptomatic feline leukemia virus-induced immunodeficiency syndrome. Antimicrob. Agents Chemother. 1990, 34, 1749-1756
24. Truyen, U.; Blewaska, S.; Schultheiss, U. Antiviral potency of interferon omega against selected canine and feline viruses. Der. Praktische Tierarzt 2002, 83, 862-865
25. Gil, S.; Leal, R.O.; McGahie, D.; Sepúlveda, N.; Duarte, A.; Niza, M.M.R.E.; Tavares, L. Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats: Clinical and laboratory evaluation. Res. Vet. Sci. 2014, 96, 79-85
26. Gil, S.; Leal, R.O.; Duarte, A.; McGahie, D.; Sepúlveda, N.; Siborro, I.; Cravo, J.; Cartaxeiro, C.; Tavares, L.M. Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter. Res. Vet. Sci. 2013, 94, 753-763
27. Leal, R.O.; Gil, S.; Duarte, A.; McGahie, D.; Sepúlveda, N.; Niza, M.M.R.E.; Tavares, L. Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega. Res. Vet. Sci. 2015, 99, 87-95
28. Leal, R.O.; Gil, S.; Sepúlveda, N.; McGahie, D.; Duarte, A.; Niza, M.M.R.E.; Tavares, L. Monitoring acute phase proteins in retrovirus infected cats undergoing feline interferon-! therapy. J. Small Anim. Pract. 2014, 55, 39-45
29. Jahoor, F.; Gazzard, B.; Phillips, G.; Sharpstone, D.; Delrosario, M.; Frazer, M.E.; Heird, W.; Smith, R.; Jackson, A. The acute-phase protein response to human immunodeficiency virus infection in human subjects. Am. J. Physiol. 1999, 276, E1092-E1098
30. Treitinger, A.; Spada, C.; da Silva, L.M.; Hermes, E.M.; Amaral, J.A.; Abdalla, D.S. Lipid and acute-phase protein alterations in HIV-1 infected patients in the early stages of infection: Correlation with CD4+ lymphocytes. Braz. J. Infect. Dis. 2001, 5, 192-199
31. Barbai, V.H.; Ujhelyi, E.; Szlávik, J.; Vietorisz, I.; Varga, L.; Fey, E.; Füst, G.; Bánhegyi, D. Changes in the levels of some acute-phase proteins in human immunodeficiency virus-1 infected patients, following interleukin-2 treatment. Clin. Exp. Immunol. 2010, 161, 134-141
32. Hosie, M.J.; Addie, D.; Belák, S.; Boucraut-Baralon, C.; Egberink, H.; Frymus, T.; Gruffydd-Jones, T.; Hartmann, K.; Lloret, A.; Lutz, H.; et al. Feline immunodeficiency. ABCD guidelines on prevention and management. J. Feline Med. Surg. 2009, 11, 575-584
33. Ceron, J.J.; Eckersall, P.D.; Martýnez-Subiela, S. Acute phase proteins in dogs and cats: Current knowledge and future perspectives. Vet. Clin. Pathol. Am. Soc. Vet. Clin. Pathol. 2005, 34, 85-99
34. Paltrinieri, S. The feline acute phase reaction. Vet. J. 2008, 177, 26-35
35. Robert-Tissot, C.; Rüegger, V.L.; Cattori, V.; Meli, M.L.; Riond, B.; Gomes-Keller, M.A.; Vögtlin, A.; Wittig, B.; Juhls, C.; Hofmann-Lehmann, R.; et al. The innate antiviral immune system of the cat: Molecular tools for the measurement of its state of activation. Vet. Immunol. Immunopathol. 2011, 143, 269-281
36. Hennet, P.R.; Camy, G.A.L.; McGahie, D.M.; Albouy, M.V. Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: A randomised, multi-centre, controlled, double-blind study in 39 cats. J. Feline Med. Surg. 2011, 13, 577-587