Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega

Research in Veterinary Science

Volumn 99, Issue , 2015, Pages 87-95

  Leal, Rodolfo O ^a,b   Gil, Solange ^a   Duarte, Ana ^a   McGahie, David ^c   Sepúlveda, Nuno ^d,e   Niza, Maria M R E ^a   Tavares, Luís ^a  

^a FACULDADE DE MEDICINA VETERINÁRIA   (Portugal)

^b CENTRE HOSPITALIER VÉTÉRINAIRE FRÉGIS   (France)

^c Virbac SA   (France)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e Center of Statistics Applications of Lisbon University CEAUL   (Portugal)

Author keywords

Cytokine; Feline; FIV; Immunomodulator; Interferon

Indexed keywords

ACUTE PHASE PROTEIN; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; RECOMBINANT INTERFERON; RECOMBINANT INTERFERON OMEGA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IMMUNOLOGIC FACTOR; INTERFERON; INTERFERON OMEGA 1; INTERLEUKIN 12P40; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CAT DISEASE; CLINICAL PROTOCOL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FELINE IMMUNODEFICIENCY VIRUS; FELINE IMMUNODEFICIENCY VIRUS INFECTION; INNATE IMMUNITY; LYMPHOCYTE COUNT; NONHUMAN; PROVIRUS; REAL TIME POLYMERASE CHAIN REACTION; VIREMIA; VIRUS INFECTION; VIRUS LOAD; ANIMAL; BLOOD; CAT; COMPARATIVE STUDY; DRUG EFFECTS; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME; VETERINARY; VIROLOGY;

FELIDAE; FELINE IMMUNODEFICIENCY VIRUS;

ADMINISTRATION, ORAL; ANIMALS; CAT DISEASES; CATS; CYTOKINES; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; IMMUNODEFICIENCY VIRUS, FELINE; IMMUNOLOGIC FACTORS; INJECTIONS, SUBCUTANEOUS; INTERFERON TYPE I; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-4; INTERLEUKIN-6; RECOMBINANT PROTEINS; RNA, MESSENGER; TREATMENT OUTCOME; VIRAL LOAD; VIREMIA;

EID: 84925047702     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2015.02.008     Document Type: Article

References (52)

1. Barnard A., Mahon B.P., Watkins J., Redhead K., Mills K.H. Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T-cell subsets as Th1, Th2 or Th0. Immunology 1996, 87:372-380.
2. Ceron J.J., Eckersall P.D., Martýnez-Subiela S. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Veterinary Clinical Pathology 2005, 34:85-99.
3. de Mari K., Maynard L., Sanquer A., Lebreux B., Eun H.-M. Therapeutic effects of recombinant feline interferon-omega on feline leukemia virus (FeLV)-infected and FeLV/feline immunodeficiency virus (FIV)-coinfected symptomatic cats. Journal of Veterinary Internal Medicine 2004, 18:477-482.
4. Day M. Basic immunology. Clinical Immunology of the Dog and Cat 2012, 11-61. Manson Publishing, London, UK. M. Day (Ed.).
5. Dean G.A., Pedersen N.C. Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection. Journal of Virology 1998, 72:9436-9440.
6. Dean G.A., Bernales J.A., Pedersen N.C. Effect of feline immunodeficiency virus on cytokine response to Listeria monocytogenes in vivo. Veterinary Immunology and Immunopathology 1998, 65:125-138.
7. Doménech A., Miró G., Collado V.M., Ballesteros N., Sanjosé L., Escolar E., et al. Use of recombinant interferon omega in feline retrovirosis: from theory to practice. Veterinary Immunology and Immunopathology 2011, 143:301-306. 10.1016/j.vetimm.2011.06.008.
8. Duan X., Yarmush D.M., Jayaraman A., Yarmush M.L. Dispensable role for interferon-gamma in the burn-induced acute phase response: a proteomic analysis. Proteomics 2004, 4:1830-1839. 10.1002/pmic.200300696.
9. Duarte A., Tavares L. Phylogenetic analysis of Portuguese Feline Immunodeficiency Virus sequences reveals high genetic diversity. Veterinary Microbiology 2006, 114:25-33. 10.1016/j.vetmic.2005.11.056.
10. Duarte A., Marques M.I., Tavares L., Fevereiro M. Phylogenetic analysis of five Portuguese strains of FIV. Archives of Virology 2002, 147:1061-1070. 10.1007/s00705-002-0785-7.
11. Etheridge A., Gomes C.P.C., Pereira R.W., Galas D., Wang K. The complexity, function and applications of RNA in circulation. Frontiers in Genetics 2013, 4:115. 10.3389/fgene.2013.00115.
12. Gil S., Leal R.O., Duarte A., McGahie D., Sepúlveda N., Siborro I., et al. Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter. Research in Veterinary Science 2013, 94:753-763. 10.1016/j.rvsc.2012.09.025.
13. Gil S., Leal R.O., McGahie D., Sepúlveda N., Duarte A., Niza M.M.R.E., et al. Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats: clinical and laboratory evaluation. Research in Veterinary Science 2014, 96:79-85. 10.1016/j.rvsc.2013.11.007.
14. Hennet P.R., Camy G.A.L., McGahie D.M., Albouy M.V. Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, double-blind study in 39 cats. Journal of Feline Medicine and Surgery 2011, 13:577-587. 10.1016/j.jfms.2011.05.012.
15. Hochepied T., Berger F.G., Baumann H., Libert C. Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine and Growth Factor Reviews 2003, 14:25-34.
16. Kennedy M.A. A brief review of the basics of immunology: the innate and adaptive response. The Veterinary Clinics of North America. Small Animal Practice 2010, 40:369-379. 10.1016/j.cvsm.2010.01.003.
17. Kipar A., Boretti F.S., Meli M.M., Failing K., Reinacher M., Lutz H. Reduced constitutive cytokine transcription in isolated monocytes of clinically healthy cats, infected with an FIV strain of low pathogenicity. Veterinary Immunology and Immunopathology 2004, 98:215-221. 10.1016/j.vetimm.2003.12.002.
18. Lawrence C.E., Callanan J.J., Willett B.J., Jarrett O. Cytokine production by cats infected with feline immunodeficiency virus: a longitudinal study. Immunology 1995, 85:568-574.
19. Leal R.O., Gil S., Brito M.T., McGahie D., Niza M.M., Tavares L. The use of oral recombinant feline interferon omega in two cats with type II diabetes mellitus and concurrent feline chronic gingivostomatitis syndrome. Irish Veterinary Journal 2013, 66:19. 10.1186/2046-0481-66-19.
20. Leal R.O., Gil S., Sepúlveda N., McGahie D., Duarte A., Niza M.M.R.E., et al. Monitoring acute phase proteins in retrovirus infected cats undergoing feline interferon-ω therapy. The Journal of Small Animal Practice 2014, 55:39-45. 10.1111/jsap.12160.
21. Lerner D.L., Grant C.K., de Parseval A., Elder J.H. FIV infection of IL-2-dependent and -independent feline lymphocyte lines: host cells range distinctions and specific cytokine upregulation. Veterinary Immunology and Immunopathology 1998, 65:277-297.
22. Leutenegger C.M., Klein D., Hofmann-Lehmann R., Mislin C., Hummel U., Böni J., et al. Rapid feline immunodeficiency virus provirus quantitation by polymerase chain reaction using the TaqMan fluorogenic real-time detection system. Journal of Virological Methods 1999, 78:105-116.
23. Levy J.K., Ritchey J.W., Rottman J.B., Davidson M.G., Liang Y.H., Jordan H.L., et al. Elevated interleukin-10-to-interleukin-12 ratio in feline immunodeficiency virus-infected cats predicts loss of type 1 immunity to Toxoplasma gondii. The Journal of Infectious Diseases 1998, 178:503-511.
24. Liang Y., Hudson L.C., Levy J.K., Ritchey J.W., Tompkins W.A., Tompkins M.B. T cells overexpressing interferon-gamma and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats. The Journal of Infectious Diseases 2000, 181:564-575. 10.1086/315226.
25. Linenberger M.L., Deng T. The effects of feline retroviruses on cytokine expression. Veterinary Immunology and Immunopathology 1999, 72:343-368.
26. Litzlbauer P., Weber K., Mueller R.S. Oral and subcutaneous therapy of canine atopic dermatitis with recombinant feline interferon omega. Cytokine 2014, 66:54-59. 10.1016/j.cyto.2013.12.001.
27. Locksley R.M., Scott P. Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunology Today 1991, 12:A58-A61. 10.1016/S0167-5699(05)80017-9.
28. Martínez-Subiela S.T.V.F., Parra Muñoz M.D., Cerón J.J.M. Proteínas de fase aguda: conceptos básicos y principales aplicaciones clínicas en medicina veterinaria [Acute phase proteins: general concepts and main clinical applications in veterinary medicine]. Anales de Veterinaria de Murcia 2001, 17:97-113.
29. Murphy B., Vapniarsky N., Hillman C., Castillo D., McDonnel S., Moore P., et al. FIV establishes a latent infection in feline peripheral blood CD4+ T lymphocytes in vivo during the asymptomatic phase of infection. Retrovirology 2012, 9:12. 10.1186/1742-4690-9-12.
30. Osborne J., Hunter S.J., Devaney E. Anti-interleukin-4 modulation of the Th2 polarized response to the parasitic nematode Brugia pahangi. Infection and Immunity 1996, 64:3461-3466.
31. Paltrinieri S. The feline acute phase reaction. Veterinary Journal (London, England: 1997) 2008, 177:26-35. 10.1016/j.tvjl.2007.06.005.
32. Pedersen N.C., Dean G.A., Bernales J., Sukura A., Higgins J. Listeria monocytogenes and Serratia marcescens infections as models for Th1/Th2 immunity in laboratory cats. Veterinary Immunology and Immunopathology 1998, 63:83-103.
33. Petersen H.H., Nielsen J.P., Heegaard P.M.H. Application of acute phase protein measurements in veterinary clinical chemistry. Veterinary Research 2004, 35:163-187. 10.1051/vetres:2004002.
34. Robert-Tissot C., Rüegger V.L., Cattori V., Meli M.L., Riond B., Gomes-Keller M.A., et al. The innate antiviral immune system of the cat: molecular tools for the measurement of its state of activation. Veterinary Immunology and Immunopathology 2011, 143:269-281. 10.1016/j.vetimm.2011.06.005.
35. Roitt I.M., Delves P.J. The production of effectors. Essential Immunology 2001, 147-164. Blackwell Publishing, Massachusetts. I.M. Roitt, P.J. Delves (Eds.).
36. Romagnani S., Del Prete G., Manetti R., Ravina A., Annunziato F., De Carli M., et al. Role of TH1/TH2 cytokines in HIV infection. Immunological Reviews 1994, 140:73-92.
37. Scott V.L., Shack L.A., Eells J.B., Ryan P.L., Donaldson J.R., Coats K.S. Immunomodulator expression in trophoblasts from the feline immunodeficiency virus (FIV)-infected cat. Virology Journal 2011, 8:336. 10.1186/1743-422X-8-336.
38. Steel D.M., Whitehead A.S. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunology Today 1994, 15:81-88. 10.1016/0167-5699(94)90138-4.
39. Taglinger K., Van Nguyen N., Helps C.R., Day M.J., Foster A.P. Quantitative real-time RT-PCR measurement of cytokine mRNA expression in the skin of normal cats and cats with allergic skin disease. Veterinary Immunology and Immunopathology 2008, 122:216-230. 10.1016/j.vetimm.2007.11.014.
40. Tizard I.R. Cell signaling: cytokines and their receptors. Veterinary Immunology: An Introduction 2009, Saunders, Missouri.
41. Tizard I.R. Helper T-cells and their response to Antigen. Veterinary Immunology: An Introduction 2009, Saunders, Missouri.
42. Tomonaga K., Inoshima Y., Ikeda Y., Mikami T. Temporal patterns of feline immunodeficiency virus transcripts in peripheral blood cells during the latent stage of infection. The Journal of General Virology 1995, 76(Pt 9):2193-2204.
43. Tompkins M.B., Tompkins W.A. Lentivirus-induced immune dysregulation. Veterinary Immunology and Immunopathology 2008, 123:45-55. 10.1016/j.vetimm.2008.01.011.
44. Tovey M.G. Oromucosal cytokine therapy: mechanism(s) of action. Taehan Kan Hakhoe chi 2002, 8:125-131.
45. Trinchieri G., Pflanz S., Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2003, 19:641-644.
46. Truyen U., Schultheiss U. A study of the anti-viral activity of interferon omega against selected canine and feline viruses. Der Praktische Tierarzt 2002, 10:862-864.
47. Ueda Y., Sakurai T., Kasama K., Satoh Y., Atsumi K., Hanawa S., et al. Pharmacokinetic properties of recombinant feline interferon and its stimulatory effect on 2',5'-oligoadenylate synthetase activity in the cat. The Journal of Veterinary Medical Science 1993, 55:1-6.
48. VanCott J.L., Staats H.F., Pascual D.W., Roberts M., Chatfield S.N., Yamamoto M., et al. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. The Journal of Immunology 1996, 156:1504-1514.
49. Vogel C., Marcotte E.M. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nature Reviews. Genetics 2012, 13:227-232. 10.1038/nrg3185.
50. Wong S.C.C., Lo E.S.F., Cheung M.T. An optimised protocol for the extraction of non-viral mRNA from human plasma frozen for three years. Journal of Clinical Pathology 2004, 57:766-768. 10.1136/jcp.2003.007880.
51. Wood B.A., Troyer R.M., Terwee J.A., Vandewoude S. Microsphere immunoassay for the detection of cytokines in domestic cat (Felis catus) plasma: elevated IL-12/23 in acute feline immunodeficiency virus infections. Veterinary Immunology and Immunopathology 2012, 145:604-610. 10.1016/j.vetimm.2012.01.005.
52. Zhao Y., Gebhard D., English R., Sellon R., Tompkins M., Tompkins W. Enhanced expression of novel CD57+CD8+ LAK cells from cats infected with feline immunodeficiency virus. Journal of Leukocyte Biology 1995, 58:423-431.