Outpatient, combined use of opioid and benzodiazepine medications in the United States, 1993–2014

Preventive Medicine Reports

Volumn 9, Issue , 2018, Pages 49-54

  Hirschtritt, Matthew E ^a   Delucchi, Kevin L ^a   Olfson, Mark ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Benzodiazepine; Medication safety; Opioid; Pain; Prescriptions

Indexed keywords

BENZODIAZEPINE; OPIATE;

ABDOMINAL PAIN; ADULT; ARTICLE; FEMALE; HEADACHE; HEALTH CARE POLICY; HEALTH PROGRAM; HEALTH SURVEY; HUMAN; ICD-9-CM; LOW BACK PAIN; MAJOR CLINICAL STUDY; MALE; MEDICAID; MEDICAL SPECIALIST; MEDICARE; NECK PAIN; OUTPATIENT; PELVIC PAIN; PRACTICE GUIDELINE; PRESCRIPTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RESPIRATION DEPRESSION; RISK FACTOR; THORAX PAIN; UNITED STATES;

EID: 85044861488     PISSN: None     EISSN: 22113355     Source Type: Journal    
DOI: 10.1016/j.pmedr.2017.12.010     Document Type: Article

References (38)

1. Abdel Shaheed, C., Maher, C.G., Williams, K.A., Day, R., McLachlan, A.J., Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain: a systematic review and meta-analysis. JAMA Intern. Med. 176:7 (2016), 958–968.
2. Bachhuber, M.A., Hennessy, S., Cunningham, C.O., Starrels, J.L., Increasing benzodiazepine prescriptions and overdose mortality in the United States, 1996–2013. Am. J. Public Health 106:4 (2016), 686–688.
3. Beauchamp, G.A., Winstanley, E.L., Ryan, S.A., Lyons, M.S., Moving beyond misuse and diversion: the urgent need to consider the role of iatrogenic addiction in the current opioid epidemic. Am. J. Public Health 104:11 (2014), 2023–2029.
4. Brands, B., Blake, J., Marsh, D.C., Sproule, B., Jeyapalan, R., Li, S., The impact of benzodiazepine use on methadone maintenance treatment outcomes. J. Addict. Dis. 27:3 (2008), 37–48.
5. Case, A., Deaton, A., Rising morbidity and mortality in midlife among white Non-Hispanic Americans in the 21st century. Proc. Natl. Acad. Sci. U. S. A. 112:49 (2015), 15078–15083.
6. Centers for Disease Control and Prevention, Ambulatory Health Care Data. https://www.cdc.gov/nchs/ahcd/index.htm.Accessed: 2017 (September 5).
7. Chan, G.M., Stajic, M., Marker, E.K., Hoffman, R.S., Nelson, L.S., Testing positive for methadone and either a tricyclic antidepressant or a benzodiazepine is associated with an accidental overdose death: analysis of medical examiner data. Acad. Emerg. Med. 13:5 (2006), 543–547.
8. Cheatle, M.D., Webster, L.R., Opioid therapy and sleep disorders: risks and mitigation strategies. Pain Med. 16:Suppl. 1 (2015), S22–6.
9. Dart, R.C., Surratt, H.L., Cicero, T.J. et al., Trends in opioid analgesic abuse and mortality in the United States. N. Engl. J. Med. 372:3 (2015), 241–248.
10. Dasgupta, N., Funk, M.J., Proescholdbell, S., Hirsch, A., Ribisl, K.M., Marshall, S., Cohort study of the impact of high-dose opioid analgesics on overdose mortality. Pain Med. 17:1 (2016), 85–98.
11. Dowell, D., Haegerich, T.M., Chou, R., CDC guideline for prescribing opioids for chronic pain—United States, 2016. JAMA 315:15 (2016), 1624–1645.
12. Garcia, A.M., State laws regulating prescribing of controlled substances: balancing the public health problems of chronic pain and prescription painkiller abuse and overdose. J. Law Med. Ethics 41:Suppl. 1 (2013), 42–45.
13. Gugelmann, H.M., Perrone, J., Can prescription drug monitoring programs help limit opioid abuse?. JAMA 306:20 (2011), 2258–2259.
14. Hassamal, S., Miotto, K., Wang, T., Saxon, A.J., A narrative review: the effects of opioids on sleep disordered breathing in chronic pain patients and methadone maintained patients. Am. J. Addict. 25:6 (2016), 452–465.
15. Hwang, C.S., Kang, E.M., Kornegay, C.J., Staffa, J.A., Jones, C.M., McAninch, J.K., Trends in the concomitant prescribing of opioids and benzodiazepines, 2002–2014. Am. J. Prev. Med. 51:2 (2016), 151–160.
16. Institute of Medicine of the National Academies, Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. 2011.
17. Jann, M., Kennedy, W.K., Lopez, G., Benzodiazepines: a major component in unintentional prescription drug overdoses with opioid analgesics. J. Pharm. Pract. 27:1 (2014), 5–16.
18. Jones, C.M., McAninch, J.K., Emergency department visits and overdose deaths from combined use of opioids and benzodiazepines. Am. J. Prev. Med. 49:4 (2015), 493–501.
19. Kandel, D.B., MC, Hu, Griesler, P., Wall, M., Increases from 2002 to 2015 in prescription opioid overdose deaths in combination with other substances. Drug Alcohol Depend. 178 (2017), 501–511.
20. Karaca-Mandic, P., Meara, E., Morden, N.E., The growing problem of co-treatment with opioids and benzodiazepines. BMJ, 356, 2017, j1224.
21. King, N.B., Fraser, V., Boikos, C., Richardson, R., Harper, S., Determinants of increased opioid-related mortality in the United States and Canada, 1990–2013: a systematic review. Am. J. Public Health 104:8 (2014), e32–42.
22. Kochanek, K.D., Arias, E., Bastian, B.A., The Effect of Changes in Selected Age-specific Causes of Death on Non-hispanic White Life Expectancy Between 2000 and 2014. 2016 Data Brief no. 250.
23. Larochelle, M.R., Zhang, F., Ross-Degnan, D., Wharam, J.F., Trends in opioid prescribing and co-prescribing of sedative hypnotics for acute and chronic musculoskeletal pain: 2001–2010. Pharmacoepidemiol. Drug Saf. 24:8 (2015), 885–892.
24. Lavie, E., Fatseas, M., Denis, C., Auriacombe, M., Benzodiazepine use among opiate-dependent subjects in buprenorphine maintenance treatment: correlates of use, abuse and dependence. Drug Alcohol Depend. 99:1–3 (2009), 338–344.
25. Mikolaenko, I., Robinson, C.A. Jr., Davis, G.G., A review of methadone deaths in Jefferson County, Alabama. Am J Forensic Med Pathol 23:3 (2002), 299–304.
26. Mogri, M., Desai, H., Webster, L., Grant, B.J., Mador, M.J., Hypoxemia in patients on chronic opiate therapy with and without sleep apnea. Sleep Breath. 13:1 (2009), 49–57.
27. National Center for Health Statistics, Centers for Disease Control and Prevention. National Ambulatory Medical Care Survey: 2014 NAMCS Micro-data File Documentation. ftp://ftp.cdc.gov/pub/Health_Statistics/NCHS/Dataset_Documentation/NAMCS/doc2014.pdf. Updated 2014, Accessed May 1, 2017.
28. Nielsen, S., Dietze, P., Lee, N., Dunlop, A., Taylor, D., Concurrent buprenorphine and benzodiazepines use and self-reported opioid toxicity in opioid substitution treatment. Addiction 102:4 (2007), 616–622.
29. Park, T.W., Saitz, R., Ganoczy, D., Ilgen, M.A., Bohnert, A.S., Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: case-cohort study. BMJ, 350, 2015, h2698.
30. Pezalla, E.J., Rosen, D., Erensen, J.G., Haddox, J.D., Mayne, T.J., Secular trends in opioid prescribing in the USA. J. Pain Res. 10 (2017), 383–387.
31. Rosenberg, E.I., Genao, I., Chen, I. et al., Complementary and alternative medicine use by primary care patients with chronic pain. Pain Med. 9:8 (2008), 1065–1072.
32. Rudd, R.A., Aleshire, N., Zibbell, J.E., Gladden, R.M., Increases in drug and opioid overdose deaths—United States, 2000–2014. MMWR Morb. Mortal. Wkly Rep. 64:50–51 (2016), 1378–1382.
33. Rudd, R.A., Seth, P., David, F., Scholl, L., Increases in drug and opioid-involved overdose deaths - United States, 2010–2015. MMWR 65:5051 (2016), 1445–1452.
34. Saunders, K.W., Von Korff, M., Campbell, C.I. et al., Concurrent use of alcohol and sedatives among persons prescribed chronic opioid therapy: prevalence and risk factors. J. Pain 13:3 (2012), 266–275.
35. Schuman-Olivier, Z., Hoeppner, B.B., Weiss, R.D., Borodovsky, J., Shaffer, H.J., Albanese, M.J., Benzodiazepine use during buprenorphine treatment for opioid dependence: clinical and safety outcomes. Drug Alcohol Depend. 132:3 (2013), 580–586.
36. Strom, B.L., Data validity issues in using claims data. Pharmacoepidemiol. Drug Saf. 10:5 (2001), 389–392.
37. Sun, E.C., Dixit, A., Humphreys, K., Darnall, B.D., Baker, L.C., Mackey, S., Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis. BMJ, 356, 2017, j760.
38. The Office of the Surgeon General, Prescribing Opioids for Chronic Pain. available at: http://Turnthetiderx.org/wp-content/uploads/2016/06/TurnTheTide_PocketGuide_Final.pdf. (Accessed 9 June 2017)