Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras

Molecular Therapy Methods and Clinical Development

Volumn 9, Issue , 2018, Pages 130-141

  Tai, Phillip W L ^a   Xie, Jun ^a   Fong, Kaiyuen ^a   Seetin, Matthew ^b   Heiner, Cheryl ^b   Su, Qin ^a   Weiand, Michael ^b   Wilmot, Daniella ^a   Zapp, Maria L ^a   Gao, Guangping ^a,c  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b PACIFIC BIOSCIENCES   (United States)

^c SICHUAN UNIVERSITY   (China)

Author keywords

AAV GPseq; gene therapy vector QC; rAAV ITR; recombinant adeno associated virus; single molecule real time sequencing

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR;

ARTICLE; BIOINFORMATICS; CHIMERA; CONTROLLED STUDY; GEL ELECTROPHORESIS; GENE SEQUENCE; GENOME ANALYSIS; HOST CELL; INVERTED TERMINAL REPEAT; NONHUMAN; PLASMID; PRIORITY JOURNAL; VIRUS GENOME;

EID: 85044860086     PISSN: None     EISSN: 23290501     Source Type: Journal    
DOI: 10.1016/j.omtm.2018.02.002     Document Type: Article

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