Salivary cytokine levels in early gingival inflammation

Journal of Oral Microbiology

Volumn 9, Issue 1, 2017, Pages

  Belstrøm, Daniel ^a   Damgaard, Christian ^a,b   Könönen, Eija ^c   Gürsoy, Mervi ^c   Holmstrup, Palle ^a   Gürsoy, Ulvi Kahraman ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Gingivitis; human; interleukin 1 receptor antagonist; interleukin 1 ; interleukin 8; monocyte chemoattractant protein 1; vascular endothelial growth factor

Indexed keywords

EID: 85044747461     PISSN: None     EISSN: 20002297     Source Type: Journal    
DOI: 10.1080/20002297.2017.1364101     Document Type: Article

References (24)

1. Darveau RP., Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010;8(7):1–6.
2. Gursoy UK, Kononen E., Editorial: use of saliva in diagnosis of periodontitis: cumulative use of bacterial and host-derived biomarkers. Front Cell Infect Microbiol. 2016;6:196.
3. Gursoy UK, Kononen E, Pradhan-Palikhe P, et al. Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis. J Clin Periodontol. 2010;37(6):487–493.
4. Jaedicke KM, Preshaw PM, Taylor JJ. Salivary cytokines as biomarkers of periodontal diseases. Periodontol 2000. 2016;70(1):164–183.
5. Syndergaard B, Al-Sabbagh M, Kryscio RJ, et al. Salivary biomarkers associated with gingivitis and response to therapy. J Periodontol. 2014;85(8):e295–e303.
6. Graves DT, Li J, Cochran DL. Inflammation and uncoupling as mechanisms of periodontal bone loss. J Dent Res. 2011;90(2):143–153.
7. Cekici A, Kantarci A, Hasturk H, et al. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontol 2000. 2014;64(1):57–80.
8. Loe H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol. 1965;36:177–187.
9. Silness J, Loe H. Periodontal diseases in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964;22:121–135.
10. Bardow A, Lykkeaa J, Qvist V, et al. Saliva composition in three selected groups with normal stimulated salivary flow rates, but yet major differences in caries experience and dental erosion. Acta Odontol Scand. 2014;72(6):466–473.
11. Dommisch H, Staufenbiel I, Schulze K, et al. Expression of antimicrobial peptides and interleukin-8 during early stages of inflammation: an experimental gingivitis study. J Periodontal Res. 2015;50(6):836–845.
12. Garlet GP, Martins W, Jr., Ferreira BR, et al. Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. J Periodontal Res. 2003;38(2):210–217.
13. Deinzer R, Weik U, Kolb-Bachofen V, et al. Comparison of experimental gingivitis with persistent gingivitis: differences in clinical parameters and cytokine concentrations. J Periodontal Res. 2007;42(4):318–324.
14. Cetinkaya BO, Keles GC, Ayas B, et al. The expression of vascular endothelial growth factor in a rat model at destruction and healing stages of periodontal disease. J Periodontol. 2007;78(6):1129–1135.
15. Wang D, Zhang S, Li L, et al. Structural insights into the assembly and activation of IL-1beta with its receptors. Nat Immunol. 2010;11(10):905–911.
16. Keles GC, Cetinkaya BO, Eroglu C, et al. Vascular endothelial growth factor expression levels of gingiva in gingivitis and periodontitis patients with/without diabetes mellitus. Inflamm Res. 2010;59(7):543–549.
17. Offenbacher S, Barros S, Mendoza L, et al. Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans. J Clin Periodontol. 2010;37(4):324–333.
18. Trombelli L, Scapoli C, Carrieri A, et al. Interleukin-1 beta levels in gingival crevicular fluid and serum under naturally occurring and experimentally induced gingivitis. J Clin Periodontol. 2010 1;37(8):697–704.
19. Scott AE, Milward M, Linden GJ, et al. Mapping biological to clinical phenotypes during the development (21 days) and resolution (21 days) of experimental gingivitis. J Clin Periodontol. 2012;39(2):123–131.
20. Morelli T, Stella M, Barros SP, et al. Salivary biomarkers in a biofilm overgrowth model. J Periodontol. 2014;85(12):1770–1778.
21. Schincaglia GP, Hong BY, Rosania A, et al. Clinical, immune, and microbiome traits of gingivitis and peri-implant mucositis. J Dent Res. 2017;96(1):47–55.
22. Meyer S, Giannopoulou C, Courvoisier D, et al. Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses. Clin Oral Implants Res. 2016. DOI:10.1111/clr.12912
23. Lee YH, Wong DT. Saliva: an emerging biofluid for early detection of diseases. Am J Dent. 2009;22(4):241–248.
24. Jasim H, Olausson P, Hedenberg-Magnusson B, et al. The proteomic profile of whole and glandular saliva in healthy pain-free subjects. Sci Rep. 2016;6:39073.