The antimicrobial peptide CRAMP is essential for colon homeostasis by maintaining microbiota balance

Journal of Immunology

Volumn 200, Issue 6, 2018, Pages 2174-2185

  Yoshimura, Teizo ^a,b   McLean, Mairi H ^a,c   Dzutsev, Amiran K ^a   Yao, Xiaohong ^d   Chen, Keqiang ^a   Huang, Jiaqiang ^a,e   Gong, Wanghua ^f   Zhou, Jiamin ^a   Xiang, Yi ^a   Badger, Jonathan H ^a   O'HUigin, Colm ^a   Thovarai, Vishal ^f   Tessarollo, Lino ^a   Durum, Scott K ^a   Trinchieri, Giorgio ^a   Bian, Xiu Wu ^d   Wang, Ji Ming ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OKAYAMA UNIVERSITY   (Japan)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

^e BEIJING JIAOTONG UNIVERSITY   (China)

^f FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN; CATHELIN RELATED ANTIMICROBIAL PEPTIDE; CILASTATIN PLUS IMIPENEM; NEOMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; CATHELIN; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL TRANSMISSION; BACTERIUM; BACTERIUM IDENTIFICATION; C57BL/6N MOUSE; CD3+ T LYMPHOCYTE; CELL COUNT; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON FLORA; CONTROLLED STUDY; DESULFOMICROBIUM ORALE; DESULFOVIBRIO PIGER; DEXTRAN SULFATE SODIUM-INDUCED COLITIS; DISEASE PREDISPOSITION; DISEASE SEVERITY; DYSBIOSIS; FECES COMPOSITION; FECES MICROFLORA; HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOREGULATION; INTESTINE MUCOSA PERMEABILITY; MALE; MOGIBACTERIUM NEGLECTUM; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHENOTYPE; POPULATION ABUNDANCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SURVIVAL RATE; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; COLITIS; COLON; DISEASE MODEL; FECES; INTESTINE FLORA; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; COLITIS; COLON; DISEASE MODELS, ANIMAL; FECES; GASTROINTESTINAL MICROBIOME; HOMEOSTASIS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICROBIOTA; PROTEINS;

EID: 85044739106     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1602073     Document Type: Article

References (26)

1. Yu, L. C., J. T. Wang, S. C. Wei, and Y. H. Ni. 2012. Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World J. Gastrointest. Pathophysiol. 3: 27-43.
2. Ishii, K. J., S. Koyama, A. Nakagawa, C. Coban, and S. Akira. 2008. Host innate immune receptors and beyond: Making sense of microbial infections. Cell Host Microbe 3: 352-363.
3. Medzhitov, R. 2007. Recognition of microorganisms and activation of the immune response. Nature 449: 819-826.
4. Le, Y., P. M. Murphy, and J. M. Wang. 2002. Formyl-peptide receptors revisited. Trends Immunol. 23: 541-548.
5. Ye, R. D., F. Boulay, J. M. Wang, C. Dahlgren, C. Gerard, M. Parmentier, C. N. Serhan, and P. M. Murphy. 2009. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol. Rev. 61: 119-161.
6. Li, L., K. Chen, Y. Xiang, T. Yoshimura, S. Su, J. Zhu, X. W. Bian, and J. M. Wang. 2016. New development in studies of formyl-peptide receptors: Critical roles in host defense. J. Leukoc. Biol. 99: 425-435.
7. Chen, K., M. Liu, Y. Liu, T. Yoshimura, W. Shen, Y. Le, S. Durum, W. Gong, C. Wang, J. L. Gao, et al. 2013. Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis. J. Clin. Invest. 123: 1694-1704.
8. Schauber, J., D. Rieger, F. Weiler, J. Wehkamp, M. Eck, K. Fellermann, W. Scheppach, R. L. Gallo, and E. F. Stange. 2006. Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases. Eur. J. Gastroenterol. Hepatol. 18: 615-621.
9. Kurosaka, K., Q. Chen, F. Yarovinsky, J. J. Oppenheim, and D. Yang. 2005. Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant. J. Immunol. 174: 6257-6265.
10. Ménard, S., V. Förster, M. Lotz, D. Gütle, C. U. Duerr, R. L. Gallo, B. Henriques-Normark, K. Pütsep, M. Andersson, E. O. Glocker, and M. W. Hornef. 2008. Developmental switch of intestinal antimicrobial peptide expression. J. Exp. Med. 205: 183-193.
11. Tai, E. K., W. K. Wu, H. P. Wong, E. K. Lam, L. Yu, and C. H. Cho. 2007. A new role for cathelicidin in ulcerative colitis in mice. Exp. Biol. Med. (Maywood) 232: 799-808.
12. Wong, C. C., L. Zhang, Z. J. Li, W. K. Wu, S. X. Ren, Y. C. Chen, T. B. Ng, and C. H. Cho. 2012. Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis. J. Gastroenterol. Hepatol. 27: 1205-1212.
13. Yang, D., G. de la Rosa, P. Tewary, and J. J. Oppenheim. 2009. Alarmins link neutrophils and dendritic cells. Trends Immunol. 30: 531-537.
14. Wirtz, S., C. Neufert, B. Weigmann, and M. F. Neurath. 2007. Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2: 541-546.
15. Neufert, C., C. Becker, and M. F. Neurath. 2007. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat. Protoc. 2: 1998-2004.
16. Iida, N., A. Dzutsev, C. A. Stewart, L. Smith, N. Bouladoux, R. A. Weingarten, D. A. Molina, R. Salcedo, T. Back, S. Cramer, et al. 2013. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 342: 967-970.
17. Laukoetter, M. G., P. Nava, W. Y. Lee, E. A. Severson, C. T. Capaldo, B. A. Babbin, I. R. Williams, M. Koval, E. Peatman, J. A. Campbell, et al. 2007. JAM-A regulates permeability and inflammation in the intestine in vivo. J. Exp. Med. 204: 3067-3076.
18. Kozich, J. J., S. L. Westcott, N. T. Baxter, S. K. Highlander, and P. D. Schloss. 2013. Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. Appl. Environ. Microbiol. 79: 5112-5120.
19. Smith, P. D., L. E. Smythies, R. Shen, T. Greenwell-Wild, M. Gliozzi, and S. M. Wahl. 2011. Intestinal macrophages and response to microbial encroachment. Mucosal Immunol. 4: 31-42.
20. Cesta, M. F. 2006. Normal structure, function, and histology of the spleen. Toxicol. Pathol. 34: 455-465.
21. Yeung, M. M., S. Melgar, V. Baranov, A. Oberg, A. Danielsson, S. Hammarström, and M. L. Hammarström. 2000. Characterisation of mucosal lymphoid aggregates in ulcerative colitis: Immune cell phenotype and TcRgammadelta expression. Gut 47: 215-227.
22. Per-se, M., and A. Cerar. 2012. Dextran sodium sulphate colitis mouse model: Traps and tricks. J. Biomed. Biotechnol. 2012: 718617.
23. Nakazawa, F., S. E. Poco, Jr., M. Sato, T. Ikeda, S. Kalfas, G. Sundqvist, and E. Hoshino. 2002. Taxonomic characterization of Mogibacterium diversum sp. nov. and Mogibacterium neglectum sp. nov., isolated from human oral cavities. Int. J. Syst. Evol. Microbiol. 52: 115-122.
24. Koon, H. W., D. Q. Shih, J. Chen, K. Bakirtzi, T. C. Hing, I. Law, S. Ho, R. Ichikawa, D. Zhao, H. Xu, et al. 2011. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology 141: 1852-1863.e1-3.
25. Rowan, F. E., N. G. Docherty, J. C. Coffey, and P. R. O'Connell. 2009. Sulphatereducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis. Br. J. Surg. 96: 151-158.
26. Travis, S. M., N. N. Anderson, W. R. Forsyth, C. Espiritu, B. D. Conway, E. P. Greenberg, P. B. McCray, Jr., R. I. Lehrer, M. J. Welsh, and B. F. Tack. 2000. Bactericidal activity of mammalian cathelicidin-derived peptides. Infect. Immun. 68: 2748-2755.