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Volumn 8, Issue , 2017, Pages

Selection of functional quorum sensing systems by lysogenic bacteriophages in pseudomonas aeruginosa

Author keywords

Phage therapy; Public goods; Quorum sensing; Social cheating; Virulence

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPETITION; GALLERIA MELLONELLA; IN VIVO STUDY; MIXED CELL CULTURE; NONHUMAN; PHAGE THERAPY; PHENOTYPE; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; WILD TYPE;

EID: 85044690665     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2017.01669     Document Type: Article
Times cited : (23)

References (47)
  • 2
    • 84960124084 scopus 로고    scopus 로고
    • Bacteriophage exploitation of bacterial biofilms: Phage preference for less mature targets?
    • Abedon, S. T. (2016). Bacteriophage exploitation of bacterial biofilms: phage preference for less mature targets? FEMS Microbiol. Lett. 363:fnv246. doi: 10. 1093/femsle/fnv246
    • (2016) FEMS Microbiol. Lett. , vol.363
    • Abedon, S.T.1
  • 3
    • 0036282814 scopus 로고    scopus 로고
    • Quorum sensing is not required for twitching motility in Pseudomonas aeruginosa
    • Beatson, S. A., Whitchurch, C. B., Semmler, A. B., and Mattick, J. S. (2002). Quorum sensing is not required for twitching motility in Pseudomonas aeruginosa. J. Bacteriol. 184, 3598–3604. doi: 10.1128/JB.184.13.3598-3604.2002
    • (2002) J. Bacteriol. , vol.184 , pp. 3598-3604
    • Beatson, S.A.1    Whitchurch, C.B.2    Semmler, A.B.3    Mattick, J.S.4
  • 5
    • 84925602702 scopus 로고    scopus 로고
    • Core and accessory genome architecture in a group of Pseudomonas aeruginosa Mu-like phages
    • Cazares, A., Mendoza-Hernandez, G., and Guarneros, G. (2014). Core and accessory genome architecture in a group of Pseudomonas aeruginosa Mu-like phages. BMC Genomics 15:1146. doi: 10.1186/1471-2164-15-1146
    • (2014) BMC Genomics , vol.15 , pp. 1146
    • Cazares, A.1    Mendoza-Hernandez, G.2    Guarneros, G.3
  • 6
    • 2942520975 scopus 로고    scopus 로고
    • Phage-host interaction: An ecological perspective
    • Chibani-Chennoufi, S., Bruttin, A., Dillmann, M. L., and Brussow, H. (2004). Phage-host interaction: an ecological perspective. J. Bacteriol. 186, 3677–3686. doi: 10.1128/JB.186.12.3677-3686.2004
    • (2004) J. Bacteriol. , vol.186 , pp. 3677-3686
    • Chibani-Chennoufi, S.1    Bruttin, A.2    Dillmann, M.L.3    Brussow, H.4
  • 7
    • 84868029980 scopus 로고    scopus 로고
    • Antibacterial efficacy of temperate phage-mediated inhibition of bacterial group motilities
    • Chung, I. Y., Sim, N., and Cho, Y.-H. (2012). Antibacterial efficacy of temperate phage-mediated inhibition of bacterial group motilities. Antimicrob. Agents Chemother. 56, 5612–5617. doi: 10.1128/AAC.00504-12
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 5612-5617
    • Chung, I.Y.1    Sim, N.2    Cho, Y.-H.3
  • 8
    • 77950648700 scopus 로고    scopus 로고
    • Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: Strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants
    • Ciofu, O., Mandsberg, L. F., Bjarnsholt, T., Wassermann, T., and Hoiby, N. (2010). Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants. Microbiology 156, 1108–1119. doi: 10.1099/mic.0.033993-0
    • (2010) Microbiology , vol.156 , pp. 1108-1119
    • Ciofu, O.1    Mandsberg, L.F.2    Bjarnsholt, T.3    Wassermann, T.4    Hoiby, N.5
  • 10
    • 36248965729 scopus 로고    scopus 로고
    • Cooperation and conflict in quorum-sensing bacterial populations
    • Diggle, S. P., Griffin, A. S., Campbell, G. S., and West, S. A. (2007). Cooperation and conflict in quorum-sensing bacterial populations. Nature 450, 411–414. doi: 10.1038/nature06279
    • (2007) Nature , vol.450 , pp. 411-414
    • Diggle, S.P.1    Griffin, A.S.2    Campbell, G.S.3    West, S.A.4
  • 11
    • 84882759726 scopus 로고    scopus 로고
    • Protist predation can favour cooperation within bacterial species
    • Friman, V. P., Diggle, S. P., and Buckling, A. (2013). Protist predation can favour cooperation within bacterial species. Biol. Lett. 9:20130548. doi: 10.1098/rsbl. 2013.0548
    • (2013) Biol. Lett , vol.9
    • Friman, V.P.1    Diggle, S.P.2    Buckling, A.3
  • 12
    • 84993949205 scopus 로고    scopus 로고
    • Is quorum sensing interference a viable alternative to treat Pseudomonas aeruginosa infections?
    • García-Contreras, R. (2016). Is quorum sensing interference a viable alternative to treat Pseudomonas aeruginosa infections? Front. Microbiol. 7:1454. doi: 10. 3389/fmicb.2016.01454
    • (2016) Front. Microbiol. , vol.7 , pp. 1454
    • García-Contreras, R.1
  • 13
    • 84930260701 scopus 로고    scopus 로고
    • Can resistance against quorum-sensing interference be selected?
    • García-Contreras, R., Maeda, T., and Wood, T. K. (2016). Can resistance against quorum-sensing interference be selected? ISME J. 10, 4–10. doi: 10.1038/ismej. 2015.84
    • (2016) ISME J , vol.10 , pp. 4-10
    • García-Contreras, R.1    Maeda, T.2    Wood, T.K.3
  • 14
    • 84923311364 scopus 로고    scopus 로고
    • Quorum sensing enhancement of the stress response promotes resistance to quorum quenching and prevents social cheating
    • García-Contreras, R., Nunez-López, L., Jasso-Chávez, R., Kwan, B. W., Belmont, J. A., Rangel-Vega, A., et al. (2015). Quorum sensing enhancement of the stress response promotes resistance to quorum quenching and prevents social cheating. ISME J. 9, 115–125. doi: 10.1038/ismej.2014.98
    • (2015) ISME J , vol.9 , pp. 115-125
    • García-Contreras, R.1    Nunez-López, L.2    Jasso-Chávez, R.3    Kwan, B.W.4    Belmont, J.A.5    Rangel-Vega, A.6
  • 15
    • 84939265907 scopus 로고    scopus 로고
    • Inhibition of quorum-sensing-dependent virulence factors and biofilm formation of clinical and environmental Pseudomonas aeruginosa strains by ZnO nanoparticles
    • García-Lara, B., Saucedo-Mora, M. A., Roldan-Sanchez, J. A., Pérez-Eretza, B., Ramasamy, M., Lee, J., et al. (2015). Inhibition of quorum-sensing-dependent virulence factors and biofilm formation of clinical and environmental Pseudomonas aeruginosa strains by ZnO nanoparticles. Lett. Appl. Microbiol. 61, 299–305. doi: 10.1111/lam.12456
    • (2015) Lett. Appl. Microbiol. , vol.61 , pp. 299-305
    • García-Lara, B.1    Saucedo-Mora, M.A.2    Roldan-Sanchez, J.A.3    Pérez-Eretza, B.4    Ramasamy, M.5    Lee, J.6
  • 16
    • 84908180998 scopus 로고    scopus 로고
    • Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria
    • Gerdt, J. P., and Blackwell, H. E. (2014). Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria. ACS Chem. Biol. 9, 2291–2299. doi: 10.1021/cb5 004288
    • (2014) ACS Chem. Biol. , vol.9 , pp. 2291-2299
    • Gerdt, J.P.1    Blackwell, H.E.2
  • 19
    • 84880156720 scopus 로고    scopus 로고
    • Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lung
    • Hogardt, M., and Heesemann, J. (2013). Microevolution of Pseudomonas aeruginosa to a chronic pathogen of the cystic fibrosis lung. Curr. Top. Microbiol. Immunol. 358, 91–118. doi: 10.1007/82_2011_199
    • (2013) Curr. Top. Microbiol. Immunol. , vol.358 , pp. 91-118
    • Hogardt, M.1    Heesemann, J.2
  • 20
    • 84999287857 scopus 로고    scopus 로고
    • Quorum regulated resistance of Vibrio cholerae against environmental bacteriophages
    • Hoque, M. M., Naser, I. B., Bari, S. M., Zhu, J., Mekalanos, J. J., and Faruque, S. M. (2016). Quorum regulated resistance of Vibrio cholerae against environmental bacteriophages. Sci. Rep. 6:37956. doi: 10.1038/srep 37956
    • (2016) Sci. Rep , vol.6
    • Hoque, M.M.1    Naser, I.B.2    Bari, S.M.3    Zhu, J.4    Mekalanos, J.J.5    Faruque, S.M.6
  • 21
    • 84874584663 scopus 로고    scopus 로고
    • A quorum-sensing-induced bacteriophage defense mechanism
    • Hoyland-Kroghsbo, N. M., Maerkedahl, R. B., and Svenningsen, S. L. (2013). A quorum-sensing-induced bacteriophage defense mechanism. mBio 4:e362-12. doi: 10.1128/mBio.00362-12
    • (2013) Mbio , vol.4 , pp. e362-e412
    • Hoyland-Kroghsbo, N.M.1    Maerkedahl, R.B.2    Svenningsen, S.L.3
  • 22
    • 84929655888 scopus 로고    scopus 로고
    • Lytic activity by temperate phages of Pseudomonas aeruginosa in long-term cystic fibrosis chronic lung infections
    • James, C. E., Davies, E. V., Fothergill, J. L., Walshaw, M. J., Beale, C. M., Brockhurst, M. A., et al. (2015). Lytic activity by temperate phages of Pseudomonas aeruginosa in long-term cystic fibrosis chronic lung infections. ISME J. 9, 1391–1398. doi: 10.1038/ismej.2014.223
    • (2015) ISME J , vol.9 , pp. 1391-1398
    • James, C.E.1    Davies, E.V.2    Fothergill, J.L.3    Walshaw, M.J.4    Beale, C.M.5    Brockhurst, M.A.6
  • 23
    • 70349622980 scopus 로고    scopus 로고
    • Viscous medium promotes cooperation in the pathogenic bacterium Pseudomonas aeruginosa
    • Kummerli, R., Griffin, A. S., West, S. A., Buckling, A., and Harrison, F. (2009). Viscous medium promotes cooperation in the pathogenic bacterium Pseudomonas aeruginosa. Proc. Biol. Sci. 276, 3531–3538. doi: 10.1098/rspb. 2009.0861
    • (2009) Proc. Biol. Sci. , vol.276 , pp. 3531-3538
    • Kummerli, R.1    Griffin, A.S.2    West, S.A.3    Buckling, A.4    Harrison, F.5
  • 24
    • 0018896292 scopus 로고
    • Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis
    • Lam, J., Chan, R., Lam, K., and Costerton, J. W. (1980). Production of mucoid microcolonies by Pseudomonas aeruginosa within infected lungs in cystic fibrosis. Infect. Immun. 28, 546–556.
    • (1980) Infect. Immun. , vol.28 , pp. 546-556
    • Lam, J.1    Chan, R.2    Lam, K.3    Costerton, J.W.4
  • 25
    • 80455130021 scopus 로고    scopus 로고
    • The sociomicrobiology of antivirulence drug resistance: A proof of concept
    • Mellbye, B., and Schuster, M. (2011). The sociomicrobiology of antivirulence drug resistance: a proof of concept. mBio 2:e00131-11. doi: 10.1128/mBio. 00131-11
    • (2011) Mbio , vol.2
    • Mellbye, B.1    Schuster, M.2
  • 26
    • 84894376028 scopus 로고    scopus 로고
    • Physiological framework for the regulation of quorum sensing-dependent public goods in Pseudomonas aeruginosa
    • Mellbye, B., and Schuster, M. (2014). Physiological framework for the regulation of quorum sensing-dependent public goods in Pseudomonas aeruginosa. J. Bacteriol. 196, 1155–1164. doi: 10.1128/JB.01223-13
    • (2014) J. Bacteriol. , vol.196 , pp. 1155-1164
    • Mellbye, B.1    Schuster, M.2
  • 27
    • 0034810591 scopus 로고    scopus 로고
    • SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities
    • Michael, B., Smith, J. N., Swift, S., Heffron, F., and Ahmer, B. M. (2001). SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities. J. Bacteriol. 183, 5733–5742. doi: 10.1128/JB.183.19.5733-5742. 2001
    • (2001) J. Bacteriol , vol.183 , pp. 5733-5742
    • Michael, B.1    Smith, J.N.2    Swift, S.3    Heffron, F.4    Ahmer, B.M.5
  • 28
    • 85013498889 scopus 로고    scopus 로고
    • Bacterial cell-to-cell signaling promotes the evolution of resistance to parasitic bacteriophages
    • Moreau, P., Diggle, S. P., and Friman, V. P. (2017). Bacterial cell-to-cell signaling promotes the evolution of resistance to parasitic bacteriophages. Ecol. Evol. 7, 1936–1941. doi: 10.1002/ece3.2818
    • (2017) Ecol. Evol. , vol.7 , pp. 1936-1941
    • Moreau, P.1    Diggle, S.P.2    Friman, V.P.3
  • 29
    • 85007389560 scopus 로고    scopus 로고
    • Bacterial competition and quorum-sensing signalling shape the eco-evolutionary outcomes of model in vitro phage therapy
    • Mumford, R., and Friman, V. P. (2017). Bacterial competition and quorum-sensing signalling shape the eco-evolutionary outcomes of model in vitro phage therapy. Evol. Appl. 10, 161–169. doi: 10.1111/eva.12435
    • (2017) Evol. Appl. , vol.10 , pp. 161-169
    • Mumford, R.1    Friman, V.P.2
  • 30
    • 84955576635 scopus 로고    scopus 로고
    • An age-dependent model to analyse the evolutionary stability of bacterial quorum sensing
    • Mund, A., Kuttler, C., Perez-Velazquez, J., and Hense, B. A. (2016). An age-dependent model to analyse the evolutionary stability of bacterial quorum sensing. J. Theor. Biol. 405, 104–115. doi: 10.1016/j.jtbi.2015. 12.021
    • (2016) J. Theor. Biol. , vol.405 , pp. 104-115
    • Mund, A.1    Kuttler, C.2    Perez-Velazquez, J.3    Hense, B.A.4
  • 31
    • 77950831062 scopus 로고    scopus 로고
    • Emergence of spatial structure in cell groups and the evolution of cooperation
    • Nadell, C. D., Foster, K. R., and Xavier, J. B. (2010). Emergence of spatial structure in cell groups and the evolution of cooperation. PLoS Comput. Biol. 6:e1000716. doi: 10.1371/journal.pcbi.1000716
    • (2010) Plos Comput. Biol. , vol.6
    • Nadell, C.D.1    Foster, K.R.2    Xavier, J.B.3
  • 32
    • 84929659599 scopus 로고    scopus 로고
    • Social evolution: Slimy cheats pay a price
    • O’Brien, S., and Brockhurst, M. A. (2015). Social evolution: slimy cheats pay a price. Curr. Biol. 25, R378–R381. doi: 10.1016/j.cub.2015.03.018
    • (2015) Curr. Biol. , vol.25 , pp. R378-R381
    • O’Brien, S.1    Brockhurst, M.A.2
  • 33
    • 84884554006 scopus 로고    scopus 로고
    • Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections
    • Papaioannou, E., Utari, P. D., and Quax, W. J. (2013). Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections. Int. J. Mol. Sci. 14, 19309–19340. doi: 10.3390/ijms140 919309
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 19309-19340
    • Papaioannou, E.1    Utari, P.D.2    Quax, W.J.3
  • 34
    • 27944485718 scopus 로고    scopus 로고
    • Conserved virulence factors of Pseudomonas aeruginosa are required for killing Bacillus subtilis
    • Park, S. Y., Heo, Y. J., Choi, Y. S., Deziel, E., and Cho, Y. H. (2005). Conserved virulence factors of Pseudomonas aeruginosa are required for killing Bacillus subtilis. J. Microbiol. 43, 443–450.
    • (2005) J. Microbiol. , vol.43 , pp. 443-450
    • Park, S.Y.1    Heo, Y.J.2    Choi, Y.S.3    Deziel, E.4    Cho, Y.H.5
  • 35
    • 85005808053 scopus 로고    scopus 로고
    • Collective sensing and collective responses in quorum-sensing bacteria
    • Popat, R., Cornforth, D. M., Mcnally, L., and Brown, S. P. (2015). Collective sensing and collective responses in quorum-sensing bacteria. J. R. Soc. Interface 12:20140882. doi: 10.1098/rsif.2014.0882
    • (2015) J. R. Soc. Interface , vol.12
    • Popat, R.1    Cornforth, D.M.2    McNally, L.3    Brown, S.P.4
  • 36
    • 84995607473 scopus 로고    scopus 로고
    • Quorum sensing influences phage infection efficiency via affecting cell population and physiological state
    • Qin, X., Sun, Q., Yang, B., Pan, X., He, Y., and Yang, H. (2016). Quorum sensing influences phage infection efficiency via affecting cell population and physiological state. J. Basic Microbiol. 57, 162–170. doi: 10.1002/jobm. 201600510
    • (2016) J. Basic Microbiol. , vol.57 , pp. 162-170
    • Qin, X.1    Sun, Q.2    Yang, B.3    Pan, X.4    He, Y.5    Yang, H.6
  • 37
    • 84995607473 scopus 로고    scopus 로고
    • Quorum sensing influences phage infection efficiency via affecting cell population and physiological state
    • Qin, X., Sun, Q., Yang, B., Pan, X., He, Y., and Yang, H. (2017). Quorum sensing influences phage infection efficiency via affecting cell population and physiological state. J. Basic Microbiol. 57, 162–170. doi: 10.1002/jobm. 201600510
    • (2017) J. Basic Microbiol , vol.57 , pp. 162-170
    • Qin, X.1    Sun, Q.2    Yang, B.3    Pan, X.4    He, Y.5    Yang, H.6
  • 38
    • 0025373755 scopus 로고
    • Pseudomonas aeruginosa transposable bacteriophages D3112 and B3 require pili and surface growth for adsorption
    • Roncero, C., Darzins, A., and Casadaban, M. J. (1990). Pseudomonas aeruginosa transposable bacteriophages D3112 and B3 require pili and surface growth for adsorption. J. Bacteriol. 172, 1899–1904. doi: 10.1128/jb.172.4.1899-1904.1990
    • (1990) J. Bacteriol. , vol.172 , pp. 1899-1904
    • Roncero, C.1    Darzins, A.2    Casadaban, M.J.3
  • 39
    • 35648980556 scopus 로고    scopus 로고
    • Social cheating in Pseudomonas aeruginosa quorum sensing
    • Sandoz, K. M., Mitzimberg, S. M., and Schuster, M. (2007). Social cheating in Pseudomonas aeruginosa quorum sensing. Proc. Natl. Acad. Sci. U.S.A. 104, 15876–15881. doi: 10.1073/pnas.0705653104
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 15876-15881
    • Sandoz, K.M.1    Mitzimberg, S.M.2    Schuster, M.3
  • 41
    • 84936980421 scopus 로고    scopus 로고
    • Quorum sensing determines the choice of antiphage defense strategy in Vibrio anguillarum
    • Tan, D., Svenningsen, S. L., and Middelboe, M. (2015). Quorum sensing determines the choice of antiphage defense strategy in Vibrio anguillarum. mBio 6:e00627-15. doi: 10.1128/mBio.00627-15
    • (2015) Mbio , vol.6
    • Tan, D.1    Svenningsen, S.L.2    Middelboe, M.3
  • 42
    • 84923294945 scopus 로고    scopus 로고
    • Quorum sensing and policing of Pseudomonas aeruginosa social cheaters
    • Wang, M., Schaefer, A. L., Dandekar, A. A., and Greenberg, E. P. (2015). Quorum sensing and policing of Pseudomonas aeruginosa social cheaters. Proc. Natl. Acad. Sci. U.S.A. 112, 2187–2191. doi: 10.1073/pnas.1500 7704112
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. 2187-2191
    • Wang, M.1    Schaefer, A.L.2    Dandekar, A.A.3    Greenberg, E.P.4
  • 43
    • 0347915669 scopus 로고    scopus 로고
    • Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112
    • Wang, P. W., Chu, L., and Guttman, D. S. (2004). Complete sequence and evolutionary genomic analysis of the Pseudomonas aeruginosa transposable bacteriophage D3112. J. Bacteriol. 186, 400–410. doi: 10.1128/JB.186.2.400-410. 2004
    • (2004) J. Bacteriol , vol.186 , pp. 400-410
    • Wang, P.W.1    Chu, L.2    Guttman, D.S.3
  • 44
    • 72449123193 scopus 로고    scopus 로고
    • Instantaneous within-patient diversity of Pseudomonas aeruginosa quorum-sensing populations from cystic fibrosis lung infections
    • Wilder, C. N., Allada, G., and Schuster, M. (2009). Instantaneous within-patient diversity of Pseudomonas aeruginosa quorum-sensing populations from cystic fibrosis lung infections. Infect. Immun. 77, 5631–5639. doi: 10.1128/IAI.0 0755-09
    • (2009) Infect. Immun. , vol.77 , pp. 5631-5639
    • Wilder, C.N.1    Allada, G.2    Schuster, M.3
  • 45
    • 84928766339 scopus 로고    scopus 로고
    • Fitness trade-offs result in the illusion of social success
    • Wolf, J. B., Howie, J. A., Parkinson, K., Gruenheit, N., Melo, D., Rozen, D., et al. (2015). Fitness trade-offs result in the illusion of social success. Curr. Biol. 25, 1086–1090. doi: 10.1016/j.cub.2015.02.061
    • (2015) Curr. Biol. , vol.25 , pp. 1086-1090
    • Wolf, J.B.1    Howie, J.A.2    Parkinson, K.3    Gruenheit, N.4    Melo, D.5    Rozen, D.6
  • 46
    • 3042597309 scopus 로고    scopus 로고
    • Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice
    • Wu, H., Song, Z., Hentzer, M., Andersen, J. B., Molin, S., Givskov, M., et al. (2004). Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice. J. Antimicrob. Chemother. 53, 1054–1061. doi: 10.1093/jac/dkh223
    • (2004) J. Antimicrob. Chemother. , vol.53 , pp. 1054-1061
    • Wu, H.1    Song, Z.2    Hentzer, M.3    Andersen, J.B.4    Molin, S.5    Givskov, M.6
  • 47
    • 84948949452 scopus 로고    scopus 로고
    • MICROBIOLOGY. Phage therapy redux–What is to be done?
    • Young, R., and Gill, J. J. (2015). MICROBIOLOGY. Phage therapy redux–What is to be done? Science 350, 1163–1164. doi: 10.1126/science.aad6791
    • (2015) Science , vol.350 , pp. 1163-1164
    • Young, R.1    Gill, J.J.2


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