No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

PLoS Neglected Tropical Diseases

Volumn 12, Issue 2, 2018, Pages

  Kimuda, Magambo Phillip ^a,b   Noyes, Harry ^c   Mulindwa, Julius ^a   Enyaru, John ^a   Alibu, Vincent Pius ^a   Sidibe, Issa ^d   Mumba Ngoyi, Dieuodonne ^e   Hertz Fowler, Christiane ^c   MacLeod, Annette ^f   Tastan Bishop, Özlem ^b   Matovu, Enock ^a  

^a MAKERERE UNIVERSITY   (Uganda)

^b RHODES UNIVERSITY   (South Africa)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d Centre International de Recherche Développement sur l Elevage en Zone Subhumide CIRDES   (Burkina Faso)

^e Institute Nationale de Rescherche Biomedicale   (Democratic Republic Congo)

^f UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN L1; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE MIGRATION INHIBITION FACTOR; TUMOR NECROSIS FACTOR; APOL1 PROTEIN, HUMAN;

ADULT; AFRICAN TRYPANOSOMIASIS; ALLELE; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPING TECHNIQUE; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM; UGANDAN; BLACK PERSON; CASE CONTROL STUDY; ETHNOLOGY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED; PARASITOLOGY; TRYPANOSOMA BRUCEI RHODESIENSE; UGANDA;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; APOLIPOPROTEIN L1; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN; UGANDA;

EID: 85044387504     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0006300     Document Type: Article

References (37)

1. Bozza MT, Martins YC, Carneiro LAM, Paiva CN, Achcar F, Kerkhoven EJ, et al. Trypanosoma brucei: Meet the system. Curr Opin Microbiol. 2013;3(November):78.
2. Franco JR, Simarro PP, Diarra A, Jannin JG, Epidemiology of human African trypanosomiasis. Clin Epidemiol. 2014;6:257–275. doi: 10.2147/CLEP.S39728 25125985
3. Funk S, Nishiura H, Heesterbeek H, Edmunds WJ, Checchi F, Identifying Transmission Cycles at the Human-Animal Interface: The Role of Animal Reservoirs in Maintaining Gambiense Human African Trypanosomiasis. PLoS Comput Biol. 2013;9(1):e1002855. doi: 10.1371/journal.pcbi.1002855 23341760
4. Lumbala C, Simarro PP, Cecchi G, Paone M, Franco JR, Kande Betu Ku Mesu V, et al. Human African trypanosomiasis in the Democratic Republic of the Congo: disease distribution and risk. Int J Health Geogr. 2015;14(1):20.
5. Simarro PP, Diarra A, Ruiz Postigo JA, Franco JR, Jannin JG, Postigo JAR, et al. The Human African trypanosomiasis control and surveillance programme of the World Health Organization 2000–2009: the way forward. PLoS Negl Trop Dis. 2011;5(2):e1007. doi: 10.1371/journal.pntd.0001007 21364972
6. Report of the first WHO stakeholders meeting on gambiense human African trypanosomiasis elimination. 2014;(March):25–27.
7. Courtin D, Milet J, Jamonneau V, Yeminanga CS, Kumeso VKB, Bilengue CMM, et al. Association between human African trypanosomiasis and the IL6 gene in a Congolese population. Infect Genet Evol. 2007;7(1):60–8. doi: 10.1016/j.meegid.2006.04.001 16720107
8. Cooper A, Ilboudo H, Alibu VP, Ravel S, Enyaru J, Weir W, et al. APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. Elife. 2017;6:1–18.
9. Courtin D, Argiro L, Jamonneau V, N’dri L, N’quessan P, Abel L, et al. Interest of tumor necrosis factor-alpha—308 G/A and interleukin-10–592 C/A polymorphisms in human African trypanosomiasis. Infect Genet Evol. 2006;6(2):123–9. doi: 10.1016/j.meegid.2005.03.002 15894515
10. Kaboré JW, Ilboudo H, Noyes H, Camara O, Kaboré J, Camara M, et al. Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. PLoS Negl Trop Dis. 2017;11(8):e0005833. doi: 10.1371/journal.pntd.0005833 28827791
11. Ofon E, Noyes H, Mulindwa J, Ilboudo H, Simuunza M, Ebo’o V, et al. A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations. PLoS Negl Trop Dis. 2017;11(10):e0005979. doi: 10.1371/journal.pntd.0005979 29077717
12. Ahouty B, Koffi M, Ilboudo H, Simo G, Matovu E, Mulindwa J, et al. Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d’Ivoire. 2017;1–13.
13. Simarro PP, Cecchi G, Paone M, Franco JR, Diarra A, Ruiz JA, et al. The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases. Int J Health Geogr. 2010;9(1):57.
14. Zhao JH, gap: Genetic Analysis Package. J Stat Softw. 2007;23(8):1–18.
15. Alvarado Arnez LE, Venegas EN, Ober C, Thompson EE, Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians. J Allergy Clin Immunol. 2011;127(1).
16. Courtin D, Milet J, Sabbagh A, Massaro JD, Castelli EC, Jamonneau V, et al. HLA-G 3’ UTR-2 haplotype is associated with Human African trypanosomiasis susceptibility. Infect Genet Evol. 2013;17:1–7. doi: 10.1016/j.meegid.2013.03.004 23541412
17. Reckenfelderbaumer N, Ludemann H, Schmidt H, Steverding D, Krauth-Siegel RL, Identification and functional characterization of thioredoxin from Trypanosoma brucei brucei. J Biol Chem. 2000;275(11):7547–7552. 10713060
18. Hertz CJ, Filutowicz H, Mansfield JM, Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol. 1998;161(0022–1767):6775–83.
19. Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, et al. MIF Contributes to Trypanosoma brucei Associated Immunopathogenicity Development. PLoS Pathog. 2014;10(9):e1004414. doi: 10.1371/journal.ppat.1004414 25255103
20. Lyke KE, Fernández-Viňa MA, Cao K, Hollenbach J, Coulibaly D, Kone AK, et al. Association of HLA alleles with Plasmodium falciparum severity in Malian children. Tissue Antigens. 2011;77(6):562–571. doi: 10.1111/j.1399-0039.2011.01661.x 21447146
21. Sortica VA, Cunha MG, Ohnishi MDO, Souza JM, Ribeiro-Dos-Santos AKC, Santos NPC, et al. IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil. Malar J. 2012;11:409. doi: 10.1186/1475-2875-11-409 23217179
22. Hardwick RJ, Ménard A, Sironi M, Milet J, Garcia A, Sese C, et al. Haptoglobin (HP) and Haptoglobin-related protein (HPR) copy number variation, natural selection, and trypanosomiasis. Hum Genet. 2014;133(1):69–83. doi: 10.1007/s00439-013-1352-x 24005574
23. Drain J, Bishop JR, Hajduk SL, Haptoglobin-related Protein Mediates Trypanosome Lytic Factor Binding to Trypanosomes. J Biol Chem. 2001;276(32):30254–30260. doi: 10.1074/jbc.M010198200 11352898
24. Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisarn T, Gilson PR, et al. Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection. J Immunol. 2016;196(3):1239–1238. doi: 10.4049/jimmunol.1501581 26700768
25. Chang CC, Chow CC, Tellier LCAM, Vattikuti S, Purcell SM, Lee JJ, Second-generation PLINK: Rising to the challenge of larger and richer datasets. Gigascience. 2015;4(1). doi: 10.1186/s13742-014-0042-5
26. Semagn K, Babu R, Hearne S, Olsen M, Single nucleotide polymorphism genotyping using Kompetitive Allele Specific PCR (KASP): overview of the technology and its application in crop improvement. Mol Breeding2014; 33:1–14.
27. Alexander DH, Novembre J, Lange K, Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 2009;19(9):1655–1664. doi: 10.1101/gr.094052.109 19648217
28. Ramasamy R, Ramasamy S, Bindroo B, Naik V, STRUCTURE PLOT: a program for drawing elegant STRUCTURE bar plots in user friendly interface. Springerplus. 2014;3(1):431.
29. Upton GJG, Fisher’s Exact Test. J R Stat Soc. 1992;155(3):395–402.
30. Benjamini Y, Hochberg Y, Controlling the false discovery rate: a practical and powerful approach to multiple testing. Vol. 57, Journal of the Royal Statistical Society. 1995. p. 289–300.
31. Van Den Oord EJCG, Controlling false discoveries in genetic studies. Am J Med Genet B Neuropsychiatr Genet. 2008;147B(5):637–644. doi: 10.1002/ajmg.b.30650 18092307
32. Picozzi K, Sleeping sickness in Uganda: a thin line between two fatal diseases. BMJ. 2005;331(7527):1238–12341. doi: 10.1136/bmj.331.7527.1238 16308383
33. Anderson C a, Pettersson FH, Clarke GM, Cardon LR, Morris AP Zondervan KT, Data quality control in genetic case-control association studies. Nat Protoc. 2010;5(9):1564–1573. doi: 10.1038/nprot.2010.116 21085122
34. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559–575. doi: 10.1086/519795 17701901
35. MacLean L, Chisi JE, Odiit M, Gibson WC, Ferris V, Picozzi K, et al. Severity of human African trypanosomiasis in East Africa is associated with geographic location, parasite genotype, and host inflammatory cytokine response profile. Infect Immun. 2004;72(12):7040–7044. doi: 10.1128/IAI.72.12.7040-7044.2004 15557627
36. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, et al. Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans. Science (80-). 2010;329(5993):841–845. doi: 10.1126/science.1193032 20647424
37. Kato CD, Matovu E, Mugasa CM, Nanteza A, Alibu VP, The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness. Allergy Asthma Clin Immunol. 2016;12:1doi: 10.1186/s13223-015-0107-8