Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea

PLoS Neglected Tropical Diseases

Volumn 11, Issue 8, 2017, Pages

  Kaboré, Justin Windingoudi ^a   Ilboudo, Hamidou ^a   Noyes, Harry ^b   Camara, Oumou ^c   Kaboré, Jacques ^a,d   Camara, Mamadou ^c   Koffi, Mathurin ^e   Lejon, Veerle ^f   Jamonneau, Vincent ^f,g   MacLeod, Annette ^h   Hertz Fowler, Christiane ^b   Belem, Adrien Marie Gaston ^d   Matovu, Enock ⁱ   Bucheton, Bruno ^c,f   Sidibe, Issa ^a  

^a Centre International de Recherche Developpement sur lElevage en zone Subhumide Bobo Dioulasso   (Burkina Faso)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c Programme National de Lutte contre la Trypanosomose Humaine Africaine   (Guinea)

^d Université Nazi Boni   (Burkina Faso)

^e Université Jean Lorougnon Guédé UJLoG   (Côte d’Ivoire)

^f INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

^g Institut Pierre Richet Bouake   (Côte d’Ivoire)

^h UNIVERSITY OF GLASGOW   (United Kingdom)

ⁱ MAKERERE UNIVERSITY   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA A ANTIGEN; HLA G ANTIGEN; INTERLEUKIN 4; INTERLEUKIN 8; MACROPHAGE MIGRATION INHIBITION FACTOR; TUMOR NECROSIS FACTOR;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; DNA POLYMORPHISM; GENE FREQUENCY; GENOTYPING TECHNIQUE; GUINEA; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MASS SCREENING; MASS SPECTROMETRY; PHENOTYPE; POLYMERASE CHAIN REACTION; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM; SPECTROPHOTOMETRY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; PATHOLOGY; TRYPANOSOMA BRUCEI GAMBIENSE;

GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GUINEA; HUMANS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 85028777011     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0005833     Document Type: Article

References (45)

1. Camara M, Kaba D, KagbaDouno M, Sanon JR, Ouendeno FF, et al. (2005) [Human African trypanosomiasis in the mangrove forest in Guinea: epidemiological and clinical features in two adjacent outbreak areas]. Med Trop (Mars)65: 155–161.
2. Simarro PP, Diarra A, Ruiz Postigo JA, Franco JR, Jannin JG, (2011) The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000–2009: the way forward. PLoS Negl Trop Dis5: e1007. doi: 10.1371/journal.pntd.0001007 21364972
3. Kagbadouno MS, Camara M, Rouamba J, Rayaisse JB, Traore IS, et al. (2012) Epidemiology of sleeping sickness in Boffa (Guinea): where are the trypanosomes?PLoS Negl Trop Dis6: e1949. doi: 10.1371/journal.pntd.0001949 23272259
4. Ilboudo H, Jamonneau V, Camara M, Camara O, Dama E, et al. (2011) Diversity of response to Trypanosoma brucei gambiense infections in the Forecariah mangrove focus (Guinea): perspectives for a better control of sleeping sickness. Microbes Infect13: 943–952. doi: 10.1016/j.micinf.2011.05.007 21658462
5. Checchi F, Filipe JA, Barrett MP, Chandramohan D, (2008) The natural progression of Gambiense sleeping sickness: what is the evidence?PLoS Negl Trop Dis2: e303. doi: 10.1371/journal.pntd.0000303 19104656
6. Jamonneau V, Ilboudo H, Kabore J, Kaba D, Koffi M, et al. (2012) Untreated human infections by Trypanosoma brucei gambiense are not 100% fatal. PLoS Negl Trop Dis6: e1691. doi: 10.1371/journal.pntd.0001691 22720107
7. Bucheton B, MacLeod A, Jamonneau V, (2011) Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections. Parasite Immunol33: 438–447. doi: 10.1111/j.1365-3024.2011.01287.x 21385185
8. Garcia A, Courtin D, Solano P, Koffi M, Jamonneau V, (2006) Human African trypanosomiasis: connecting parasite and host genetics. Trends Parasitol22: 405–409. doi: 10.1016/j.pt.2006.06.011 16837245
9. Checchi F, Filipe JA, Haydon DT, Chandramohan D, Chappuis F, (2008) Estimates of the duration of the early and late stage of gambiense sleeping sickness. BMC Infect Dis8: 16. doi: 10.1186/1471-2334-8-16 18261232
10. Sternberg JM, Maclean L, (2010) A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence. Parasitology137: 2007–2015. doi: 10.1017/S0031182010000946 20663245
11. Jamonneau V, Ravel S, Garcia A, Koffi M, Truc P, et al. (2004) Characterization of Trypanosoma brucei s.l. infecting asymptomatic sleeping-sickness patients in Côte d'Ivoire: a new genetic group?Ann Trop Med Parasitol98: 329–337. doi: 10.1179/000349804225003406 15228714
12. Jamonneau V, Garcia A, Ravel S, Cuny G, Oury B, et al. (2002) Genetic characterization of Trypanosoma brucei gambiense and clinical evolution of human African trypanosomiasis in Cote d'Ivoire. Trop Med Int Health7: 610–621. 12100445
13. Iraqi F, Clapcott SJ, Kumari P, Haley CS, Kemp SJ, et al. (2000) Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mamm Genome11: 645–648. 10920233
14. Kemp SJ, Iraqi F, Darvasi A, Soller M, Teale AJ, (1997) Localization of genes controlling resistance to trypanosomiasis in mice. Nat Genet16: 194–196. doi: 10.1038/ng0697-194 9171834
15. Courtin D, Argiro L, Jamonneau V, N'Dri L, N'Guessan P, et al. (2006) Interest of tumor necrosis factor-alpha -308 G/A and interleukin-10–592 C/A polymorphisms in human African trypanosomiasis. Infect Genet Evol6: 123–129. doi: 10.1016/j.meegid.2005.03.002 15894515
16. Courtin D, Milet J, Jamonneau V, Yeminanga CS, Kumeso VK, et al. (2007) Association between human African trypanosomiasis and the IL6 gene in a Congolese population. Infect Genet Evol7: 60–68. doi: 10.1016/j.meegid.2006.04.001 16720107
17. Ilboudo H, Bras-Goncalves R, Camara M, Flori L, Camara O, et al. (2014) Unravelling human trypanotolerance: IL8 is associated with infection control whereas IL10 and TNFalpha are associated with subsequent disease development. PLoS Pathog10: e1004469. doi: 10.1371/journal.ppat.1004469 25375156
18. Courtin D, Milet J, Sabbagh A, Massaro JD, Castelli EC, et al. (2013) HLA-G 3' UTR-2 haplotype is associated with Human African trypanosomiasis susceptibility. Infect Genet Evol17: 1–7. doi: 10.1016/j.meegid.2013.03.004 23541412
19. Ilboudo H, Jamonneau V, Koffi M, Kabore J, Amoussa R, et al. (2016) Trypanosome-induced Interferon-gamma production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections. Microbes Infect18: 436–440. doi: 10.1016/j.micinf.2016.03.002 26993030
20. Cooper A, Ilboudo H, Alibu VP, Ravel S, Enyaru J, et al. (2017) APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. Elife6.
21. Ilboudo H, Noyes H, Mulindwa J, Kimuda MP, Koffi M, et al. (2017) Introducing the TrypanoGEN biobank: A valuable resource for the elimination of human African trypanosomiasis. PLoS Negl Trop Dis11: e0005438. doi: 10.1371/journal.pntd.0005438 28570558
22. Camara M, Camara O, Ilboudo H, Sakande H, Kabore J, et al. (2010) Sleeping sickness diagnosis: use of buffy coats improves the sensitivity of the mini anion exchange centrifugation test. Trop Med Int Health15: 796–799. doi: 10.1111/j.1365-3156.2010.02546.x 20497407
23. Van Meirvenne N, Magnus E, Buscher P, (1995) Evaluation of variant specific trypanolysis tests for serodiagnosis of human infections with Trypanosoma brucei gambiense. Acta Trop60: 189–199. 8907397
24. Zhao JH, (December2007) Genetic Analysis Package. Journal of Statistical Software23: 1–18.
25. Semagn K, Babu R, Hearne S, Olsen M, (2014) Single nucleotide polymorphism genotyping using Kompetitive Allele Specific PCR (KASP): overview of the technology and its application in crop improvement. Molecular Breeding33: 1–14.
26. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet81: 559–575. doi: 10.1086/519795 17701901
27. Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP, et al. (2010) Data quality control in genetic case-control association studies. Nat Protoc5: 1564–1573. doi: 10.1038/nprot.2010.116 21085122
28. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, et al. (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science329: 841–845. doi: 10.1126/science.1193032 20647424
29. Perez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, Nolan DP, Lins L, et al. (2005) Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Science309: 469–472. doi: 10.1126/science.1114566 16020735
30. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, et al. (2003) Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature422: 83–87. doi: 10.1038/nature01461 12621437
31. Vanwalleghem G, Fontaine F, Lecordier L, Tebabi P, Klewe K, et al. (2015) Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1. Nat Commun6: 8078. doi: 10.1038/ncomms9078 26307671
32. Ilboudo H, Berthier D, Camara M, Camara O, Kabore J, et al. (2012) APOL1 expression is induced by Trypanosoma brucei gambiense infection but is not associated with differential susceptibility to sleeping sickness. Infect Genet Evol12: 1519–1523. doi: 10.1016/j.meegid.2012.05.010 22691369
33. Vanhollebeke B, Pays E, (2010) The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill. Mol Microbiol76: 806–814. doi: 10.1111/j.1365-2958.2010.07156.x 20398209
34. Cuypers B, Lecordier L, Meehan CJ, Van den Broeck F, Imamura H, et al. (2016) Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection. MBio7: e02198–02115. doi: 10.1128/mBio.02198-15 27073096
35. Pays E, (2006) The variant surface glycoprotein as a tool for adaptation in African trypanosomes. Microbes Infect8: 930–937. doi: 10.1016/j.micinf.2005.10.002 16480910
36. Kieft R, Capewell P, Turner CMR, Veitch NJ, MacLeod A, et al. (2010) Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proc Natl Acad Sci U S A107: 16137–16141. doi: 10.1073/pnas.1007074107 20805508
37. Lecordier L, Vanhollebeke B, Poelvoorde P, Tebabi P, Paturiaux-Hanocq F, et al. (2009) C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. PLoS Pathog5: e1000685. doi: 10.1371/journal.ppat.1000685 19997494
38. Consortium TG, (2015) The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans. Science (New York, NY)348: 648–660.
39. Kim S, Yu NK, Kaang BK, (2015) CTCF as a multifunctional protein in genome regulation and gene expression. Exp Mol Med47: e166. doi: 10.1038/emm.2015.33 26045254
40. de Vries HE, Blom-Roosemalen MC, van Oosten M, de Boer AG, van Berkel TJ, et al. (1996) The influence of cytokines on the integrity of the blood-brain barrier in vitro. J Neuroimmunol64: 37–43. 8598388
41. Girard M, Giraud S, Courtioux B, Jauberteau-Marchan MO, Bouteille B, (2005) Endothelial cell activation in the presence of African trypanosomes. Mol Biochem Parasitol139: 41–49. doi: 10.1016/j.molbiopara.2004.09.008 15610818
42. Calandra T, Froidevaux C, Martin C, Roger T, (2003) Macrophage migration inhibitory factor and host innate immune defenses against bacterial sepsis. J Infect Dis187Suppl 2: S385–390.
43. Renner P, Roger T, Calandra T, (2005) Macrophage migration inhibitory factor: gene polymorphisms and susceptibility to inflammatory diseases. Clin Infect Dis41Suppl 7: S513–519.
44. de Jesus Fernandes Covas C, Cardoso CC, Gomes-Silva A, Santos Oliveira JR, Da-Cruz AM, et al. (2013) Candidate gene case-control and functional study shows macrophage inhibitory factor (MIF) polymorphism is associated with cutaneous leishmaniasis. Cytokine61: 168–172. doi: 10.1016/j.cyto.2012.09.012 23068083
45. Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, et al. (2014) MIF contributes to Trypanosoma brucei associated immunopathogenicity development. PLoS Pathog10: e1004414. doi: 10.1371/journal.ppat.1004414 25255103