POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease

Immunity, Inflammation and Disease

Volumn 5, Issue 2, 2017, Pages 98-108

  Buelow, Becky J ^a   Rohlfing, Michelle ^a   Jung, Franscoise ^b   Douglas, Garry J ^b   Grayson, Mitchell H ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b Polyphor Ltd   (Switzerland)

Author keywords

Asthma; Chemokines; Therapeutics

Indexed keywords

BETA CHEMOKINE; CCL28 PROTEIN, MOUSE; CCR10 PROTEIN, MOUSE; CHEMOKINE RECEPTOR CCR10;

ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; COMPLICATION; HUMAN; IMMUNOLOGY; MOUSE; RESPIROVIRUS INFECTION; SENDAI VIRUS; VIROLOGY;

ANIMALS; ASTHMA; CHEMOKINES, CC; HUMANS; MICE; RECEPTORS, CCR10; RESPIROVIRUS INFECTIONS; SENDAI VIRUS;

EID: 85044327542     PISSN: None     EISSN: 20504527     Source Type: Journal    
DOI: 10.1002/iid3.147     Document Type: Article

References (24)

1. Kay, A. B. 2001. Allergy and allergic diseases. First of two parts. N. Engl. J. Med. 344(1):30-37.
2. Sigurs, N., R. Bjarnason, F. Sigurbergsson, B. Kjellman, and B. Bjorksten. 1995. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics 95(4):500-555.
3. Grayson, M. H., D. Cheung, M. M. Rohlfing, R. Kitchens, D. E. Spiegel, J. Tucker, J. T. Battaile, Y. Alevy, L. Yan, E. Agapov, et al. 2007. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J. Exp. Med. 204(11):2759-2769.
4. Cheung, D. S., S. J. Ehlenbach, R. T. Kitchens, D. A. Riley, L. L. Thomas, M. J. Holtzman, and M. H. Grayson. 2010. Cutting edge: CD49dþ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. J. Immunol. 185(9):4983-4987.
5. Thomas, M. A., B. J. Buelow, A. M. Nevins, S. E. Jones, F. C. Peterson, R. L. Gundry, M. H. Grayson, and B. F. Volkman. 2015. Structure-function analysis of CCL28 in the development of post-viral asthma. J. Biol. Chem. 290(7):4528-4536.
6. Wang, W., H. Soto, E. R. Oldham, M. E. Buchanan, B. Homey, D. Catron, N. Jenkins, N.G. Copeland, D. J. Gilbert, N. Nguyen, et al. 2000. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275(29):22313-22323.
7. Pan, J., E. J. Kunkel, U. Gosslar, N. Lazarus, P. Langdon, K. Broadwell, M. A. Vierra, M. C. Genovese, E. C. Butcher, and D. Soler. 2000. A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. J. Immunol. 165(6):2943-2949.
8. Nagakubo, D., O. Yoshie, and T. Hirata. 2016. Upregulated CCL28 expression in the nasal mucosa in experimental allergic rhinitis: implication for CD4(þ) memory T cell recruitment. Cell Immunol. 302:58-62.
9. English, K., C. Brady, P. Corcoran, J. P. Cassidy, and B. P. Mahon. 2006. Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma. Immunol. Lett. 103(2):92-100.
10. Xiong, N., Y. Fu, S. Hu, M. Xia, and J. Yang. 2012. CCR10 and its ligands in regulation of epithelial immunity and diseases. Protein Cell. 3(8):571-580.
11. John, A. E., M. S. Thomas, A. A. Berlin, and N. W. Lukacs. 2005. Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. Am. J. Pathol. 166(2):345-353.
12. Daubeuf, F., F. Jung, G. J. Douglas, E. Chevalier, and N. Frossard. 2015. Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation. Respir. Res. 16:77.
13. Ezzat, M. H., M. A. Sallam, and K. Y. Shaheen. 2009. Serum mucosa-associated epithelial chemokine (MEC/CCL28) in atopic dermatitis: a specific marker for severity. Int. J. Dermatol. 48(8):822-829.
14. Khan, S. H., and M. H. Grayson. 2010. Cross-linking IgE augments human conventional dendritic cell production of CC chemokine ligand 28. J. Allergy Clin. Immunol. 125(1):265-267.
15. Cheung, D. S., S. J. Ehlenbach, T. Kitchens, D. A. Riley, and M. H. Grayson. 2010. Development of atopy by severe paramyxoviral infection in a mouse model. Ann. Allergy Asthma Immunol. 105(6):437-443 e1.
16. Tyner, J.W., O. Uchida, N. Kajiwara, E. Y. Kim, A.C. Patel, M. P. O’Sullivan, M. J. Walter, R. A. Schwendener, D.N.C ook, T.M. Danoff, et al. 2005. CCL5-CCR5 interaction provides antiapoptotic signals formacrophage survival during viral infection. Nat. Med. 11(11):1180-1187.
17. Kim, E. Y., J. T. Battaile, A. C. Patel, Y. You, E. Agapov, M. H. Grayson, L. A. Benoit, D. E. Byers, Y. Alevy, J. Tucker, et al. 2008. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat. Med. 14(6):633-640.
18. Chang, Y. J., H. Y. Kim, L. A. Albacker, N. Baumgarth, A. N. McKenzie, D. E. Smith, R.H. Dekruyff, and D.T Umetsu. 2011. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat. Immunol. 12(7):631-638.
19. Cheng, G., M. Arima, K. Honda, H. Hirata, F. Eda, N. Yoshida, F. Fukushima, Y. Ishii, and T. Fukuda. 2002. Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Am. J. Respir. Crit. Care Med. 166(3):409-416.
20. Zhang X., Goncalves R., and Mosser D.M. The isolation and characterization of murine macrophages. Curr Protoc Immunol. Ed: John E Coligan [et al]. 2008;Chapter 14: Unit 14 1.
21. Vasudev, M., D. S. Cheung, H. Pincsak, S. H. Li, K. Yan, P. Simpson, T. Dasu, and M. H. Grayson. 2012. Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children. PLoS ONE 7(2):e32556.
22. Klemens, J. J., K. Thompson, A. Langerman, and R.M. Naclerio. 2006. Persistent inflammation and hyperresponsiveness following viral rhinosinusitis. Laryngoscope 116(7):1236-1240.
23. Gill, M. A., G. Bajwa, T. A. George, C. C. Dong, I. I. Dougherty, N. Jiang, V. N. Gan, and R. S. Gruchalla. 2010. Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. J. Immunol. 184(11):5999-6006.
24. Walter M. J., J. D. Morton, N. Kajiwara, E. Agapov, and M. J. Holtzman. 2002. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J. Clin. Invest. 110(2):165-175.