Protective effect of a protein epitope mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation

Respiratory Research

Volumn 16, Issue 1, 2015, Pages

  Daubeuf, François ^a   Jung, Françoise ^b   Douglas, Garry J ^b   Chevalier, Eric ^b   Frossard, Nelly ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b Polyphor Ltd   (Switzerland)

Author keywords

Airway hyperresponsiveness; Allergen; Asthma; CCL28; CCR10; Eosinophilia; Inflammation; Mouse; Ovalbumin

Indexed keywords

CCL28 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR10; COLLAGEN; DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; POL 7085; UNCLASSIFIED DRUG; CCR10 PROTEIN, MOUSE; EPITOPE;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ALLERGIC EOSINOPHILIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY PLETHYSMOGRAPHY; CELL COUNT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG STRUCTURE; DRUG TISSUE LEVEL; EOSINOPHILIA; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; RESPIRATORY TRACT ALLERGY; TH2 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; BAGG ALBINO MOUSE; BRONCHIAL HYPERREACTIVITY; CHEMISTRY; PATHOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PULMONARY EOSINOPHILIA;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; MALE; MICE; MICE, INBRED BALB C; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PULMONARY EOSINOPHILIA; RECEPTORS, CCR10;

EID: 84937044243     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-015-0231-5     Document Type: Article

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