Elevated Cardiac Troponin T in Patients With Skeletal Myopathies

Journal of the American College of Cardiology

Volumn 71, Issue 14, 2018, Pages 1540-1549

  Schmid, Johannes ^a   Liesinger, Laura ^a,b   Birner Gruenberger, Ruth ^a,b   Stojakovic, Tatjana ^a   Scharnagl, Hubert ^a   Dieplinger, Benjamin ^c   Asslaber, Martin ^a   Radl, Roman ^a   Beer, Meinrad ^d   Polacin, Malgorzata ^d   Mair, Johannes ^e   Szolar, Dieter ^a   Berghold, Andrea ^a   Quasthoff, Stefan ^a   Binder, Josepha S ^a   Rainer, Peter P ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b BIOTECHMED GRAZ   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY HOSPITAL ULM   (Germany)

^e INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

cardiac troponin; myopathy; skeletal muscle

Indexed keywords

CREATINE KINASE; MYOGLOBIN; TROPONIN I; TROPONIN T; BIOLOGICAL MARKER;

ADULT; ARTICLE; AUTOPSY; CARDIOVASCULAR MAGNETIC RESONANCE; CINEANGIOCARDIOGRAPHY; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; FEMALE; GENETIC DISORDER; HEART INFARCTION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; MUSCLE TISSUE; MYOPATHY; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REFERENCE VALUE; TROPONIN T BLOOD LEVEL; BLOOD; CARDIAC MUSCLE; DIAGNOSTIC IMAGING; IMMUNOASSAY; METABOLISM; MIDDLE AGED; MUSCLE DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; SKELETAL MUSCLE; WESTERN BLOTTING; X-RAY COMPUTED TOMOGRAPHY;

ADULT; BIOMARKERS; BLOTTING, WESTERN; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; IMMUNOASSAY; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MUSCULAR DISEASES; MYOCARDIUM; TOMOGRAPHY, X-RAY COMPUTED; TROPONIN T;

EID: 85044129487     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2018.01.070     Document Type: Article

References (31)

1. Gomes, A.V., Potter, J.D., Szczesna-Cordary, D., The role of troponins in muscle contraction. IUBMB Life 54 (2002), 323–333.
2. Thygesen, K., Alpert, J.S., Jaffe, A.S., et al. Third universal definition of myocardial infarction. J Am Coll Cardiol 60 (2012), 1581–1598.
3. Roffi, M., Patrono, C., Collet, J.P., et al. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 37 (2016), 267–315.
4. Wang, A.Y., Lai, K.N., Use of cardiac biomarkers in end-stage renal disease. J Am Soc Nephrol 19 (2008), 1643–1652.
5. Müller-Bardorff, M., Hallermayer, K., Schröder, A., et al. Improved troponin T ELISA specific for cardiac troponin T isoform: assay development and analytical and clinical validation. Clin Chem 43 (1997), 458–466.
6. Jaffe, A.S., Vasile, V.C., Milone, M., Saenger, A.K., Olson, K.N., Apple, F.S., Diseased skeletal muscle: a noncardiac source of increased circulating concentrations of cardiac troponin T. J Am Coll Cardiol 58 (2011), 1819–1824.
7. Rittoo, D., Jones, A., Lecky, B., Neithercut, D., Elevation of cardiac troponin T but not cardiac troponin I in patients with neuromuscular diseases: implications for the diagnosis of myocardial infarction. J Am Coll Cardiol 63 (2014), 2411–2420.
8. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310 (2013), 2191–2194.
9. Kramer, C.M., Barkhausen, J., Flamm, S.D., et al. Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update. J Cardiovasc Magn Reson, 15, 2013, 91.
10. Yancy, C.W., Jessup, M., Bozkurt, B., et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 62 (2013), e147–e239.
11. Kawel-Boehm, N., Maceira, A., Valsangiacomo-Buechel, E.R., et al. Normal values for cardiovascular magnetic resonance in adults and children. J Cardiovasc Magn Reson, 17, 2015, 29.
12. Reichlin, T., Cullen, L., Parsonage, W.A., et al. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Am J Med 128 (2015), 369–379.e4.
13. Binder, J.S., Weidemann, F., Schoser, B., et al. Spongious hypertrophic cardiomyopathy in patients with mutations in the four-and-a-half LIM domain 1 gene. Circ Cardiovasc Genet 5 (2012), 490–502.
14. Yilmaz, A., Sechtem, U., Cardiac involvement in muscular dystrophy: advances in diagnosis and therapy. Heart 98 (2012), 420–429.
15. Lau, J.K., Sy, R.W., Corbett, A., Kritharides, L., Myotonic dystrophy and the heart: a systematic review of evaluation and management. Int J Cardiol 184 (2015), 600–608.
16. Matthews, E., Fialho, D., Tan, S.V., et al. The non-dystrophic myotonias: molecular pathogenesis, diagnosis and treatment. Brain J Neurol 133 (2010), 9–22.
17. Adam MP, Ardinger HH, Pagon RA, et al. eds. GeneReviews(®). Seattle (WA): University of Washington, Seattle; 1993. Available at: http://www.ncbi.nlm.nih.gov/books/NBK1116/. Accessed October 7, 2017.
18. Valaperta, R., Gaeta, M., Cardani, R., et al. High-sensitive cardiac troponin T (hs-cTnT) assay as serum biomarker to predict cardiac risk in myotonic dystrophy: a case-control study. Clin Chim Acta 463 (2016), 122–128.
19. Ergul, Y., Ekici, B., Nisli, K., et al. Evaluation of the North Star Ambulatory Assessment scale and cardiac abnormalities in ambulant boys with Duchenne muscular dystrophy. J Paediatr Child Health 48 (2012), 610–616.
20. Messner, B., Baum, H., Fischer, P., Quasthoff, S., Neumeier, D., Expression of messenger RNA of the cardiac isoforms of troponin T and I in myopathic skeletal muscle. Am J Clin Pathol 114 (2000), 544–549.
21. Li, D., Keffer, J., Corry, K., Vazquez, M., Jialal, I., Nonspecific elevation of troponin T levels in patients with chronic renal failure. Clin Biochem 28 (1995), 474–477.
22. Katus, H.A., Haller, C., Müller-Bardorff, M., Scheffold, T., Remppis, A., Cardiac troponin T in end-stage renal disease patients undergoing chronic maintenance hemodialysis. Clin Chem 41 (1995), 1201–1203.
23. Kobayashi, S., Tanaka, M., Tamura, N., Hashimoto, H., Hirose, S., Serum cardiac troponin T in polymyositis/dermatomyositis. Lancet, 340, 1992, 726.
24. Hammerer-Lercher, A., Erlacher, P., Bittner, R., et al. Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy. Clin Chem 47 (2001), 451–458.
25. Lindberg, C., Klintberg, L., Oldfors, A., Raised troponin T in inclusion body myositis is common and serum levels are persistent over time. Neuromuscul Disord 16 (2006), 495–497.
26. Aggarwal, R., Lebiedz-Odrobina, D., Sinha, A., Manadan, A., Case, J.P., Serum cardiac troponin T, but not troponin I, is elevated in idiopathic inflammatory myopathies. J Rheumatol 36 (2009), 2711–2714.
27. Cox, F.M., Delgado, V., Verschuuren, J.J., et al. The heart in sporadic inclusion body myositis: a study in 51 patients. J Neurol 257 (2010), 447–451.
28. Ricchiuti, V., Voss, E.M., Ney, A., Odland, M., Anderson, P.A., Apple, F.S., Cardiac troponin T isoforms expressed in renal diseased skeletal muscle will not cause false-positive results by the second generation cardiac troponin T assay by Boehringer Mannheim. Clin Chem 44 (1998), 1919–1924.
29. Burch, P.M., Pogoryelova, O., Goldstein, R., et al. Muscle-derived proteins as serum biomarkers for monitoring disease progression in three forms of muscular dystrophy. J Neuromuscul Dis 2 (2015), 241–255.
30. Wens, S.C.A., Schaaf, G.J., Michels, M., et al. Elevated plasma cardiac troponin T levels caused by skeletal muscle damage in Pompe disease. Circ Cardiovasc Genet 9 (2016), 6–13.
31. Bakay, M., Zhao, P., Chen, J., Hoffman, E.P., A web-accessible complete transcriptome of normal human and DMD muscle. Neuromuscul Disord 12 Suppl 1 (2002), S125–S141.