Attenuation of pulmonary ACE2 activity impairs inactivation of des-arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 314, Issue 1, 2018, Pages L17-L31

  Sodhi, Chhinder P ^a   Wohlford Lenane, Christine ^b   Yamaguchi, Yukihiro ^a   Prindle, Thomas ^a   Fulton, William B ^a   Wang, Sanxia ^a   McCray, Paul B ^b   Chappell, Mark ^c   Hackam, David J ^a   Jia, Hongpeng ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin converting enzyme 2; Bradykinin receptor B1; C X C motif chemokine 5; Endotoxin; Lung inflammation

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; BRADYKININ; BRADYKININ B1 RECEPTOR; C X C MOTIF CHEMOKINE 1; CHEMOKINE; DES ARG9 BRADYKININ; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BRADYKININ, DES-ARG(9)-; DIPEPTIDYL CARBOXYPEPTIDASE;

AIRWAY EPITHELIUM CELL; ANIMAL TISSUE; ARTICLE; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG FUNCTION; LUNG INJURY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECT; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRACHEA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRADYKININ; CELLS, CULTURED; CHEMOKINE CXCL5; HUMANS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; PEPTIDYL-DIPEPTIDASE A; PNEUMONIA; RECEPTOR, BRADYKININ B1; TRACHEA;

EID: 85043467113     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00498.2016     Document Type: Article

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