Whole-Genome-Sequence-Based Haplotypes Reveal Single Origin of the Sickle Allele during the Holocene Wet Phase

American Journal of Human Genetics

Volumn 102, Issue 4, 2018, Pages 547-556

  Shriner, Daniel ^a   Rotimi, Charles N ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

ancestral recombination graph; balancing selection; Green Sahara; haplotype; sickle

Indexed keywords

ALLELE; ANCESTRAL RECOMBINATION GRAPH; ARABIAN; ARTICLE; BALANCING SELECTION; BENIN; BIOINFORMATICS; CAMEROON; CENTRAL AFRICAN REPUBLIC; CITIZEN GROUP; CONTROLLED STUDY; GENE CLUSTER; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENE MUTATION; GENE REGULATORY NETWORK; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; GENETIC VARIATION; HAPLOTYPE; HETEROZYGOSITY; HETEROZYGOTE; HOLOCENE; HOLOCENE WET PHASE; HUMAN; INDIAN; KENYA; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; PHYLOGENETIC NETWORK ANALYSIS; PRIORITY JOURNAL; QATAR; RESTRICTION SITE; SENEGAL; SICKLE ALLELE; SICKLE MUTATION; SOUTH AFRICA; UGANDA; WHOLE GENOME SEQUENCING; BIOLOGY; GENETIC MARKER; GENETIC SELECTION; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY; RESTRICTION MAPPING; SICKLE CELL ANEMIA; TIME FACTOR;

ALLELES; ANEMIA, SICKLE CELL; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; GENETIC MARKERS; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MOLECULAR SEQUENCE ANNOTATION; PHYLOGENY; RESTRICTION MAPPING; SELECTION, GENETIC; TIME FACTORS; WHOLE GENOME SEQUENCING;

EID: 85042869587     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2018.02.003     Document Type: Article

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