Mesenchymal stem cells attenuate adriamycin-induced nephropathy by diminishing oxidative stress and inflammation via downregulation of the NF-kB

Nephrology

Volumn 23, Issue 5, 2018, Pages 483-492

  Song, In Hwan ^a   Jung, Kyong Jin ^a   Lee, Tae Jin ^a   Kim, Joo Young ^a   Sung, Eon Gi ^a   Bae, Young Chul ^a   Park, Yong Hoon ^b  

^a Yeungnam University College of Medicine   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

adriamycin; inflammation; mesenchymal stem cells; nephropathy; NF kB; oxidative; stress

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD4 ANTIGEN; CD8 ANTIGEN; COLLAGEN TYPE 1; CYCLOOXYGENASE 2; FIBRONECTIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE P38; NEPHRIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; AUTACOID; DOXORUBICIN;

ADRIAMYCIN-INDUCED NEPHROPATHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOWN REGULATION; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; KIDNEY TUBULE CELL; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NEPHRITIS; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; COCULTURE; DISEASE MODEL; FIBROSIS; FOCAL GLOMERULOSCLEROSIS; KIDNEY; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME FACTOR; ULTRASTRUCTURE;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; DOXORUBICIN; FIBROSIS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; INFLAMMATION MEDIATORS; KIDNEY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; NF-KAPPA B; OXIDATIVE STRESS; PHENOTYPE; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 85042508947     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/nep.13047     Document Type: Article

References (26)

1. Ascon M, Ascon DB, Liu M et al. Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int. 2009; 75 (5): 526–535.
2. Bi B, Schmitt R, Israilova M, Nishio H, Cantley LG. Stromal cells protect against acute tubular injury via an endocrine effect. J. Am. Soc. Nephrol. 2007; 18 (9): 2486–2496.
3. Boor P, Floege J. Chronic kidney disease growth factors in renal fibrosis. Clin. Exp. Pharmacol. Physiol. 2011; 38 (7): 441–450.
4. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414 (6865): 813–820.
5. Caplan AI. The mesengenic process. Clin. Plast. Surg. 1994; 21 (3): 429–435.
6. Castro-Manrreza ME, Montesinos JJ. Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications. J. Immunol. Res. 2015; 2015: 394917.
7. Erpicum P, Detry O, Weekers L et al. Mesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion. Nephrol. Dial. Transplant. 2014; 29 (8): 1487–1493.
8. Ezquer ME, Ezquer FE, Arango-Rodriguez ML, Conget PA. MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy. Biol. Res. 2012; 45 (3): 289–296.
9. Fujimura T, Yamagishi S, Ueda S et al. Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats. Nephrol. Dial. Transplant. 2009; 24 (5): 1397–1406.
10. Jin M, Xie Y, Li Q, Chen X. Stem cell-based cell therapy for glomerulonephritis. Biomed. Res. Int. 2014; 2014: 124730.
11. Jung KJ, Jang HS, Kim JI, Han SJ, Park JW, Park KM. Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction. Biochim. Biophys. Acta 2013; 1832 (12): 1989–1997.
12. Lee VW, Harris DC. Adriamycin nephropathy: a model of focal segmental glomerulosclerosis. Nephrology (Carlton) 2011; 16 (1): 30–38.
13. Liu YL, Wang YD, Zhuang F et al. Immunosuppression effects of bone marrow mesenchymal stem cells on renal interstitial injury in rats with unilateral ureteral obstruction. Cell. Immunol. 2012; 276 (1–2): 144–152.
14. Machado JR, Rocha LP, Neves PD et al. An overview of molecular mechanism of nephrotic syndrome. Int J Nephrol. 2012; 2012: 937623.
15. Magnasco A, Corselli M, Bertelli R et al. Mesenchymal stem cells protective effect in adriamycin model of nephropathy. Cell Transplant. 2008; 17 (10–11): 1157–1167.
16. Otaki Y, Miyauchi N, Higa M et al. Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis. Am. J. Physiol. Renal Physiol. 2008; 295 (5): F1376–F1387.
17. Qian H, Yang H, Xu W et al. Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells. Int. J. Mol. Med. 2008; 22 (3): 325–332.
18. Salmon AB, Perez VI, Bokov A et al. Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span. FASEB J. 2009; 23 (10): 3601–3608.
19. Sanz AB, Sanchez-Nino MD, Ramos AM et al. NF-kappaB in renal inflammation. J. Am. Soc. Nephrol. 2010; 21 (8): 1254–1262.
20. Song IH, Dennis JE. Simple evaluation method for osteoinductive capacity of cells or scaffolds using ceramic cubes. Tissue Cell 2014; 46 (5): 372–378.
21. Valle-Prieto A, Conget PA. Human mesenchymal stem cells efficiently manage oxidative stress. Stem Cells Dev. 2010; 19 (12): 1885–1893.
22. Wang Y, Wang Y, Cao Q et al. By homing to the kidney, activated macrophages potently exacerbate renal injury. Am. J. Pathol. 2008; 172 (6): 1491–1499.
23. Yu C, Huang D, Wang K et al. Advanced oxidation protein products induce apoptosis, and upregulate sclerostin and RANKL expression, in osteocytic MLO-Y4 cells via JNK/p38 MAPK activation. Molecular medicine reports. 2016. Epub ahead.
24. Yu R, Shtil AA, Tan TH, Roninson IB, Kong AN. Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis. Cancer Lett. 1996; 107 (1): 73–81.
25. Zheng Z, Schmidt-Ott KM, Chua S et al. A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse. Proc. Natl. Acad. Sci. U. S. A. 2005; 102 (7): 2502–2507.
26. Zoja C, Abbate M, Remuzzi G. Progression of renal injury toward interstitial inflammation and glomerular sclerosis is dependent on abnormal protein filtration. Nephrol. Dial. Transplant. 2015; 30 (5): 706–712.