Beta-Defensin-2 and Beta-Defensin-3 Reduce Intestinal Damage Caused by Salmonella typhimurium Modulating the Expression of Cytokines and Enhancing the Probiotic Activity of Enterococcus faecium

Journal of Immunology Research

Volumn 2017, Issue , 2017, Pages

  Fusco, Alessandra ^a   Savio, Vittoria ^a   Cammarota, Marcella ^a   Alfano, Alberto ^a   Schiraldi, Chiara ^a   Donnarumma, Giovanna ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 2; BETA DEFENSIN 3; CYTOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROBIOTIC AGENT; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; BETA DEFENSIN; BETA-DEFENSIN 3, HUMAN; DEFB4A PROTEIN, HUMAN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL VIABILITY; CACO-2 CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENTIATION; ENTEROCOCCUS FAECIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; INTESTINE INJURY; MIXED INFECTION; REAL TIME POLYMERASE CHAIN REACTION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS; CELL CULTURE TECHNIQUE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IMMUNOMODULATION; INTESTINE MUCOSA; METABOLISM; MICROFLORA; PHYSIOLOGY;

BETA-DEFENSINS; CACO-2 CELLS; CELL CULTURE TECHNIQUES; CYTOKINES; ENTEROCOCCUS FAECIUM; GENE EXPRESSION REGULATION; HUMANS; IMMUNOMODULATION; INTESTINAL MUCOSA; MICROBIOTA; PROBIOTICS; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM;

EID: 85042487298     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2017/6976935     Document Type: Article

References (53)

1. L. V. Hooper, D. R. Littman, and A. J. Macpherson, "Interactions between the microbiota and the immune system," Science, vol. 336, pp. 1268-1273, 2012.
2. W. S. Garrett, C. A. Gallini, T. Yatsunenko et al., "Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis," Cell Host &Microbe, vol. 8, pp. 292-300, 2010.
3. J. Bollrath and F. M. Powrie, "Controlling the frontier: regulatory T-cells and intestinal homeostasis," Seminars in Immunology, vol. 25, pp. 352-357, 2013.
4. P. J. Sansonetti, "Microbiota and the immune system, an amazing mutualism forged by co-evolution," Seminars in Immunology, vol. 25, pp. 321-322, 2013.
5. F. Bäckhed, H. Ding, T. Wang et al., "The gut microbiota as an environmental factor that regulates fat storage," Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 44, pp. 15718-15723, 2004.
6. R. Krajmalnik-Brown, Z. E. Ilhan, D. W. Kang, and J. K. DiBaise, "Effects of gut microbes on nutrient absorption and energy regulation," Nutrition in Clinical Practice, vol. 27, no. 2, pp. 201-214, 2012.
7. C. M. Franz, M. Huch, H. Abriouel, W. Holzapfel, and A. Gálvez, "Enterococci as probiotics and their implications in food safety," International Journal of Food Microbiology, vol. 151, no. 2, pp. 125-140, 2011.
8. N. I. Agudelo Higuita and M. M. Huycke, "Enterococcal disease, epidemiology, and implications for treatment," in Enterococci: From Commensals to Leading Causes of Drug Resistant Infection [Internet], M. S. Gilmore, D. B. Clewell, Y. Ike and N. Shankar, Eds., Massachusetts Eye and Ear Infirmary, Boston, 2014.
9. C. A. Arias and B. E. Murray, "The rise of the Enterococcus: beyond vancomycin resistance," Nature Reviews Microbiology, vol. 10, no. 4, pp. 266-278, 2012.
10. S. Benenson, M. J. Cohen, C. Block et al.JIRMI Group et al., "Vancomycin-resistant enterococci in long-term care facilities," Infection Control and Hospital Epidemiology, vol. 30, no. 8, pp. 786-789, 2009.
11. K. Fisher and C. Phillips, "The ecology, epidemiology and virulence of Enterococcus," Microbiology, vol. 5, Part 6, pp. 1749-1757, 2009.
12. E. Tarasova, E. Yermolenko, V. Donets et al., "The influence of probiotic Enterococcus faecium strain L5 on the microbiota and cytokines expression in rats with dysbiosis induced by antibiotics," Beneficial Microbes, vol. 1, no. 3, pp. 265-270, 2010.
13. M. Thirabunyanon and P. Hongwittayakorn, "Potential probiotic lactic acid bacteria of human origin induce antiproliferation of colon cancer cells via synergic actions in adhesion to cancer cells and short-chain fatty acid bioproduction," Applied Biochemistry and Biotechnology, vol. 169, no. 2, pp. 511-525, 2013.
14. Z. Wang, W. Chai, M. Burwinkel et al., "Inhibitory influence of Enterococcus faecium on the propagation of swine influenza A virus in vitro," PLoS One, vol. 8, no. 1, article e53043, 2013.
15. Y. Miyazaki, S. Kamiya, T. Hanawa et al., "Effect of probiotic bacterial strains of Lactobacillus, Bifidobacterium, and Enterococcus on enteroaggregative Escherichia coli," Journal of Infection and Chemotherapy, vol. 16, no. 1, pp. 10-18, 2010.
16. I. F. Ness, D. B. Diep, and Y. Ike, "Enterococcal bacteriocins and antimicrobial proteins that contribute to niche control," in Enterococci: From Commensals to Leading Causes of Drug Resistant Infection, M. S. Gilmore, D. B. Clewell, Y. Ike and N. Shankar, Eds., Massachusetts Eye and Ear Infirmary, Boston, 2014.
17. H. Khan, S. Flint, and P. L. Yu, "Enterocins in food preservation," International Journal of Food Microbiology, vol. 141, no. 1-2, pp. 1-10, 2010.
18. F. Leroy, M. R. Foulquié Moreno, and L. De Vuyst, "Enterococcus faecium RZS C5, an interesting bacteriocin producer to be used as a co-culture in food fermentation," International Journal of Food Microbiology, vol. 88, no. 2-3, pp. 235-240, 2003.
19. D. Taras, W. Vahjen, M. Macha, and O. Simon, "Performance, diarrhea incidence, and occurrence of virulence genes during long-term administration of a probiotic strain to sows and piglets," Journal of Animal Science, vol. 84, no. 3, pp. 608-617, 2006.
20. A. Zeyner and E. Boldt, "Effects of a probiotic Enterococcus faecium strain supplemented from birth to weaning on diarrhoea patterns and performance of piglets," Journal of Animal Physiology and Animal Nutrition, vol. 90, no. 1-2, pp. 25-31, 2006.
21. S. Klingspor, A. Bondzio, H. Martens et al., "Enterococcus faecium NCIMB 10415 modulates epithelial integrity, heat shock protein, and proinflammatory cytokine response in intestinal cells," Mediators of Inflammation, vol. 2015, Article ID 304149, 11 pages, 2015.
22. L. R. Schiller, "Infectious disease: a germy world-food-borne infections in 2009," Nature Reviews Gastroenterology &Hepatology, vol. 6, no. 4, pp. 197-198, 2009.
23. A. T. Gewirtz, A. S. Rao, P. O. Simon Jr et al., "Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kB pathway," The Journal of Clinical Investigation, vol. 105, no. 1, pp. 79-92, 2000.
24. M. S. Kim, Y. S. Yoon, J. G. Seo, H. G. Lee, M. J. Chung, and D. Y. Yum, "A study on the prevention of salmonella infection by using the aggregation characteristics of lactic acid bacteria," Toxicology Research, vol. 29, no. 2, pp. 129-135, 2013.
25. S. P. Brown, L. Le Chat, and F. Taddei, "Evolution of virulence: triggering host inflammation allows invading pathogens to exclude competitors," Ecology Letters, vol. 11, no. 1, pp. 44-51, 2008.
26. Y. J. Yang, C. C. Chuang, H. B. Yang, C. C. Lu, and B. S. Sheu, "Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFkB pathways," BMC Microbiology, vol. 12, p. 38, 2012.
27. L. R. McCabe, R. Irwin, L. Schaefer, and R. A. Britton, "Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice," Journal of Cellular Physiology, vol. 228, no. 8, pp. 1793-1798, 2013.
28. R. Dimitrijevic, N. Ivanovic, G. Mathiesen et al., "Effects of Lactobacillus rhamnosus LA68 on the immune system of C57BL/6 mice upon oral administration," The Journal of Dairy Research, vol. 81, no. 2, pp. 202-207, 2014.
29. N. Ivanovic, R. Minic, L. Dimitrijevic, S. Radojevic Skodric, I. Zivkovic, and B. Djordjevic, "Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis," Food &Function, vol. 6, no. 2, pp. 558-565, 2015.
30. C. Li, S. P. Nie, K. X. Zhu et al., "Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease," Food &Function, vol. 5, no. 12, pp. 3216-3223, 2014.
31. G. Donnarumma, I. Paoletti, A. Fusco et al., "β-defensins: work in progress," Advances in Experimental Medicine and Biology, vol. 901, pp. 59-76, 2016.
32. A. Fusco, L. Coretti, V. Savio, E. Buommino, F. Lembo, and G. Donnarumma, "Biofilm formation and immunomodulatory activity of proteus mirabilis clinically isolated strains," International Journal of Molecular Sciences, vol. 18, no. 2, p. 414, 2017.
33. T. Ganz, "Defensins: antimicrobial peptides of innate immunity," Nature Reviews. Immunology, vol. 3, no. 9, pp. 710-720, 2003.
34. J. Harder, J. Bartels, E. Christophers, and J. M. Schroder, "Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic," The Journal of Biological Chemistry, vol. 276, no. 8, pp. 5707-5713, 2001.
35. A. Dunsche, Y. Açil, H. Dommisch, R. Siebert, J. M. Schröder, and S. Jepsen, "The novel human beta-defensin-3 is widely expressed in oral tissues," European Journal of Oral Sciences, vol. 110, no. 2, pp. 121-124, 2002.
36. J. M. Ageitos, A. Sánchez-Pérez, P. Calo-Mata, and T. G. Villa, "Antimicrobial peptides (AMPs): ancient compounds that represent novel weapons in the fight against bacteria," Biochemical Pharmacology, vol. 133, pp. 117-138, 2016.
37. F. Niyonsaba, H. Ogawa, and I. Nagaoka, "Humanβ-defensin-2 functions as a chemotactic agent for tumour necrosis factor-α-treated human neutrophils," Immunology, vol. 111, no. 3, pp. 273-281, 2004.
38. P. Morganti, A. Fusco, I. Paoletti et al., "Anti-inflammatory, immunomodulatory, and tissue repair activity on human keratinocytes by green innovative nanocomposites," Materials, vol. 10, no. 7, p. 843, 2017.
39. J. Harder, J. Bartels, E. Christophers, and J. M. Schröder, "A peptide antibiotic from human skin," Nature, vol. 387, no. 6636, p. 861, 1997.
40. B. A. Dale and S. Krisanaprakornkit, "Defensin antimicrobial peptides in the oral cavity," Journal of Oral Pathology &Medicine, vol. 30, no. 6, pp. 321-332, 2001.
41. D. G. Carothers, S. M. Graham, H. P. Jia, M. R. Ackermann, B. F. Tack, and P. B. McCray Jr, "Production of β-defensin antimicrobial peptides by maxillary sinus mucosa," American Journal of Rhinology, vol. 15, no. 3, pp. 175-179, 2001.
42. A. M. McDermott, R. L. Redfern, B. Zhang, Y. Pei, L. Huang, and R. J. Proske, "Defensin expression by the cornea: multiple signalling pathways mediate IL-1β stimulation of hBD-2 expression by human corneal epithelial cells," Investigative Ophthalmology &Visual Science, vol. 44, no. 5, pp. 1859-1865, 2003.
43. R. Ley, D. Peterson, and J. Gordon, "Ecological and evolutionary forces shaping microbial diversity in the human intestine," Cell, vol. 124, pp. 837-848, 2006.
44. J. Qin, R. Li, J. Raes et al., "A human gut microbial gene catalogue established by metagenomic sequencing," Nature, vol. 464, pp. 59-65, 2010.
45. A. P. A. Hendrickx, W. van Schaik, and R. J. L. Willems, "The cell wall architecture of Enterococcus faecium: from resistance to pathogenesis," Future Microbiology, vol. 8, no. 8, pp. 993-1010, 2013.
46. N. Silva, G. Igrejas, A. Gonçalves, and P. Poeta, "Commensal gut bacteria: distribution of Enterococcus species and prevalence of Escherichia coli phylogenetic groups in animals and humans in Portugal," Annales de Microbiologie, vol. 62, no. 2, pp. 449-459, 2011.
47. L. Eckmann, M. F. Kagnoff, and J. Fierer, "Intestinal epithelial cells as watchdogs for the natural immune system," Trends in Microbiology, vol. 3, pp. 118-120, 1995.
48. L. Eckmann, M. F. Kagnoff, and J. Fierer, "Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry," Infection and Immunity, vol. 61, pp. 4569-4574, 1993.
49. B. A. McCormick, S. P. Colgan, C. Delp-Archer, S. I. Miller, and J. L. Madara, "Salmonella typhimurium attachment to human intestinal epithelial monolayers: transcellular signalling to subepithelial neutrophils," The Journal of Cell Biology, vol. 123, pp. 895-907, 1993.
50. H. C. Jung, L. Eckmann, S. K. Yang et al., "A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion," The Journal of Clinical Investigation, vol. 95, pp. 55-65, 1995.
51. A. R. Franz, G. Steinbach, M. Kron, and F. Pohlandt, "Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections," Pediatrics, vol. 104, pp. 447-453, 1999.
52. M. Krueger, M. S. Nauck, S. Sang, R. Hentschel, H. Wieland, and R. Berner, "Cord blood levels of interleukin-6 and interleukin-8 for the immediate diagnosis of early-onset infection in premature infants," Biology of the Neonate, vol. 80, pp. 118-123, 2001.
53. M. Pasupuleti, A. Schmidtchen, and M. Malmsten, "Antimicrobial peptides: key components of the innate immune system," Critical Reviews in Biotechnology, vol. 32, no. 2, pp. 143-171, 2012.