메뉴 건너뛰기




Volumn 127, Issue , 2018, Pages 129-137

Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi

Author keywords

Anti diabetic; Antioxidant; CYP2E1; GLUT4; Physalis alkekengi

Indexed keywords

ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BETA ACTIN; CHOLESTEROL; CYTOCHROME P450 2E1; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; MESSENGER RNA; PHYSALIS ALKEKENGI EXTRACT; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; FLAVONOID; POLYPHENOL;

EID: 85042405225     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2018.02.015     Document Type: Article
Times cited : (32)

References (38)
  • 1
    • 84898603925 scopus 로고    scopus 로고
    • Adjuvant effect of polysaccharide from fruits of Physalis alkekengi L. in DNA vaccine against systemic candidiasis
    • Yang, H., Han, S., Zhao, D., Wang, G., Adjuvant effect of polysaccharide from fruits of Physalis alkekengi L. in DNA vaccine against systemic candidiasis. Carbohydr. Polym. 109 (2014), 77–84.
    • (2014) Carbohydr. Polym. , vol.109 , pp. 77-84
    • Yang, H.1    Han, S.2    Zhao, D.3    Wang, G.4
  • 2
    • 84888161401 scopus 로고    scopus 로고
    • Origin and concept of medicine food homology and its application in modern functional foods
    • Hou, Y., Jiang, J.G., Origin and concept of medicine food homology and its application in modern functional foods. Food Funct. 4 (2013), 1727–1741.
    • (2013) Food Funct. , vol.4 , pp. 1727-1741
    • Hou, Y.1    Jiang, J.G.2
  • 3
    • 85028893704 scopus 로고    scopus 로고
    • Physalis alkekengi L. var. franchetii (Mast.) Makino: an ethnomedical, phytochemical and pharmacological review
    • Li, A.L., Chen, B.J., Li, G.H., Zhou, M.X., Li, Y.R., Ren, D.M., Lou, H.X., Wang, X.N., Shen, T., Physalis alkekengi L. var. franchetii (Mast.) Makino: an ethnomedical, phytochemical and pharmacological review. J. Ethnopharmacol. 210((2018), 260–274.
    • (2018) J. Ethnopharmacol. , vol.210 , pp. 260-274
    • Li, A.L.1    Chen, B.J.2    Li, G.H.3    Zhou, M.X.4    Li, Y.R.5    Ren, D.M.6    Lou, H.X.7    Wang, X.N.8    Shen, T.9
  • 4
    • 85014206053 scopus 로고    scopus 로고
    • Anti-hyperglycemic activity of polysaccharides from calyx of Physalis alkekengi var. franchetii Makino on alloxan-induced mice
    • Guo, Y., Li, S.J., Li, J.X., Ren, Z.Y., Chen, F., Wang, X.W., Anti-hyperglycemic activity of polysaccharides from calyx of Physalis alkekengi var. franchetii Makino on alloxan-induced mice. Int. J. Biol. Macromol. 99((2017), 249–257.
    • (2017) Int. J. Biol. Macromol. , vol.99 , pp. 249-257
    • Guo, Y.1    Li, S.J.2    Li, J.X.3    Ren, Z.Y.4    Chen, F.5    Wang, X.W.6
  • 5
    • 84873455468 scopus 로고    scopus 로고
    • A possible inhibitory effect of Physalis (Physalis pubescens L.) on diabetes in male rats
    • Hassan, A.I., Ghoneim, M.A.M., A possible inhibitory effect of Physalis (Physalis pubescens L.) on diabetes in male rats. World Appl. Sci. J. 21:5 (2013), 681–688.
    • (2013) World Appl. Sci. J. , vol.21 , Issue.5 , pp. 681-688
    • Hassan, A.I.1    Ghoneim, M.A.M.2
  • 6
    • 79960967032 scopus 로고    scopus 로고
    • Antidiabetic properties of Physalis alkekengi extract in alloxan-induced diabetic rats
    • Sanchooli, N., Antidiabetic properties of Physalis alkekengi extract in alloxan-induced diabetic rats. Res. J. Pharm. Biol. Chem. Sci. 2:3 (2011), 168–173.
    • (2011) Res. J. Pharm. Biol. Chem. Sci. , vol.2 , Issue.3 , pp. 168-173
    • Sanchooli, N.1
  • 7
    • 0028927062 scopus 로고
    • Calystegins of Physalis alkekengi var. francheti (Solanaceae). Structure determination and their glycosidase inhibitory activities
    • Asano, N., Kato, A., Oseki, K., Kizu, H., Matsui, K., Calystegins of Physalis alkekengi var. francheti (Solanaceae). Structure determination and their glycosidase inhibitory activities. Eur. J. Biochem. 229:2 (1995), 369–376.
    • (1995) Eur. J. Biochem. , vol.229 , Issue.2 , pp. 369-376
    • Asano, N.1    Kato, A.2    Oseki, K.3    Kizu, H.4    Matsui, K.5
  • 8
    • 0029117244 scopus 로고
    • Age and sex dependence of the effects of an aqueous extract of Physalis alkekengi fruits on rat hepatic glucose 6-P dehydrogenase activity
    • Vessal, M., Mostafavi-Pour, Z., Kooshesh, F., Age and sex dependence of the effects of an aqueous extract of Physalis alkekengi fruits on rat hepatic glucose 6-P dehydrogenase activity. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 111:4 (1995), 675–680.
    • (1995) Comp. Biochem. Physiol. B Biochem. Mol. Biol. , vol.111 , Issue.4 , pp. 675-680
    • Vessal, M.1    Mostafavi-Pour, Z.2    Kooshesh, F.3
  • 9
    • 36049030291 scopus 로고    scopus 로고
    • Structural characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Physalis alkekengi L
    • Tong, H., Liang, Z., Wang, G., Structural characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Physalis alkekengi L. Carbohydr. Polym. 71 (2008), 316–323.
    • (2008) Carbohydr. Polym. , vol.71 , pp. 316-323
    • Tong, H.1    Liang, Z.2    Wang, G.3
  • 10
    • 84919697366 scopus 로고    scopus 로고
    • Molecular mechanisms of GLUT4 regulation in adipocytes
    • Govers, R., Molecular mechanisms of GLUT4 regulation in adipocytes. Diabete Metab. 40:6 (2014), 400–410.
    • (2014) Diabete Metab. , vol.40 , Issue.6 , pp. 400-410
    • Govers, R.1
  • 11
    • 78650287924 scopus 로고    scopus 로고
    • Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo
    • Huang, B., Ke, H., He, J., Ban, X., Zeng, H., Wang, Y., Extracts of Halenia elliptica exhibit antioxidant properties in vitro and in vivo. Food Chem. Toxicol. 49:1 (2011), 185–190.
    • (2011) Food Chem. Toxicol. , vol.49 , Issue.1 , pp. 185-190
    • Huang, B.1    Ke, H.2    He, J.3    Ban, X.4    Zeng, H.5    Wang, Y.6
  • 13
    • 84902547914 scopus 로고    scopus 로고
    • CYP2E1 impairs GLUT4 gene expression and function: NRF2 as a possible mediator
    • Armoni, M., Harel, C., Ramdas, M., Karnieli, E., CYP2E1 impairs GLUT4 gene expression and function: NRF2 as a possible mediator. Horm. Metab. Res. 46:7 (2014), 477–483.
    • (2014) Horm. Metab. Res. , vol.46 , Issue.7 , pp. 477-483
    • Armoni, M.1    Harel, C.2    Ramdas, M.3    Karnieli, E.4
  • 14
    • 84856010479 scopus 로고    scopus 로고
    • The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications
    • Horváth, B., Mukhopadhyay, P., Haskó G., Pacher, P., The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications. J. Pathol. 180:2 (2012), 432–442.
    • (2012) J. Pathol. , vol.180 , Issue.2 , pp. 432-442
    • Horváth, B.1    Mukhopadhyay, P.2    Haskó, G.3    Pacher, P.4
  • 15
    • 33847072735 scopus 로고    scopus 로고
    • Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
    • Raun, K., von Voss, P., Gotfredsen, C.F., Golozoubova, V., Rolin, B., Knudsen, L.B., Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not. Diabetes 56:1 (2007), 8–15.
    • (2007) Diabetes , vol.56 , Issue.1 , pp. 8-15
    • Raun, K.1    von Voss, P.2    Gotfredsen, C.F.3    Golozoubova, V.4    Rolin, B.5    Knudsen, L.B.6
  • 16
    • 0036156736 scopus 로고    scopus 로고
    • Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression
    • Woodcroft, K.J., Hafner, M.S., Novak, R.F., Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression. Hepatology 35 (2002), 263–273.
    • (2002) Hepatology , vol.35 , pp. 263-273
    • Woodcroft, K.J.1    Hafner, M.S.2    Novak, R.F.3
  • 17
    • 0019502884 scopus 로고
    • Non-enzymatically glycosylated serum protein in diabetes mellitus: an index of short-term glycaemia
    • Kennedy, L., Mehl, T., Riley, W., Merimee, T., Non-enzymatically glycosylated serum protein in diabetes mellitus: an index of short-term glycaemia. Diabetologia 21:2 (1981), 94–98.
    • (1981) Diabetologia , vol.21 , Issue.2 , pp. 94-98
    • Kennedy, L.1    Mehl, T.2    Riley, W.3    Merimee, T.4
  • 18
    • 84946724966 scopus 로고    scopus 로고
    • Analytical evaluation of the Diazyme glycated serum protein assay on the siemens ADVIA 1800: comparison of results against HbA1c for diagnosis and management of diabetes
    • Rodriguez-Capote, K., Tovell, K., Holmes, D., Dayton, J., Higgins, T.N., Analytical evaluation of the Diazyme glycated serum protein assay on the siemens ADVIA 1800: comparison of results against HbA1c for diagnosis and management of diabetes. J. Diabet. Sci. Technol. 9:2 (2015), 192–199.
    • (2015) J. Diabet. Sci. Technol. , vol.9 , Issue.2 , pp. 192-199
    • Rodriguez-Capote, K.1    Tovell, K.2    Holmes, D.3    Dayton, J.4    Higgins, T.N.5
  • 19
    • 84886858307 scopus 로고    scopus 로고
    • Modulation of liver function, antioxidant responses, insulin resistance and glucose transport by Oroxylum indicum stem bark in STZ induced diabetic rats
    • Singh, J., Kakkar, P., Modulation of liver function, antioxidant responses, insulin resistance and glucose transport by Oroxylum indicum stem bark in STZ induced diabetic rats. Food Chem. Toxicol. 62((2013), 722–731.
    • (2013) Food Chem. Toxicol. , vol.62 , pp. 722-731
    • Singh, J.1    Kakkar, P.2
  • 20
    • 84901218205 scopus 로고    scopus 로고
    • In vitro synergistic antioxidant activity and identification of antioxidant components from Astragalus membranaceus and Paeonia lactiflora
    • Xu, X., Li, F., Zhang, X., Wu, Z., Li, D., In vitro synergistic antioxidant activity and identification of antioxidant components from Astragalus membranaceus and Paeonia lactiflora. PLoS One(5), 2014, e96780.
    • (2014) PLoS One , Issue.5
    • Xu, X.1    Li, F.2    Zhang, X.3    Wu, Z.4    Li, D.5
  • 21
    • 84890964329 scopus 로고    scopus 로고
    • α-Glucosidase inhibition by luteolin: kinetics, interaction and molecular docking
    • Yan, J., Zhang, G., Pan, J., Wang, Y., α-Glucosidase inhibition by luteolin: kinetics, interaction and molecular docking. Int. J. Biol. Macromol. 64((2014), 213–223.
    • (2014) Int. J. Biol. Macromol. , vol.64 , pp. 213-223
    • Yan, J.1    Zhang, G.2    Pan, J.3    Wang, Y.4
  • 22
    • 70349512259 scopus 로고    scopus 로고
    • Reactive oxygen species enhance insulin sensitivity
    • Loh, K., Deng, H., Fukushima, A., Tiganis, T., Reactive oxygen species enhance insulin sensitivity. Cell Metab. 10:4 (2009), 260–272.
    • (2009) Cell Metab. , vol.10 , Issue.4 , pp. 260-272
    • Loh, K.1    Deng, H.2    Fukushima, A.3    Tiganis, T.4
  • 23
    • 41349109370 scopus 로고    scopus 로고
    • High glucose induced human umbilical vein endothelial cell injury: involvement of protein tyrosine nitration
    • Zhao, Y., Lu, N., Li, H., Zhang, Y., Gao, Z., Gong, Y., High glucose induced human umbilical vein endothelial cell injury: involvement of protein tyrosine nitration. Mol. Cell. Biochem. 311 (2008), 19–29.
    • (2008) Mol. Cell. Biochem. , vol.311 , pp. 19-29
    • Zhao, Y.1    Lu, N.2    Li, H.3    Zhang, Y.4    Gao, Z.5    Gong, Y.6
  • 24
    • 84900458819 scopus 로고    scopus 로고
    • Investigation of antioxidant interactions between Radix Astragali and Cimicifuga foetida and identification of synergistic antioxidant compounds
    • Wang, F., Zhao, S., Li, F., Zhang, B., Qu, Y., Sun, T., Luo, T., Li, D., Investigation of antioxidant interactions between Radix Astragali and Cimicifuga foetida and identification of synergistic antioxidant compounds. PLoS One, 9(1), 2014, e87221.
    • (2014) PLoS One , vol.9 , Issue.1
    • Wang, F.1    Zhao, S.2    Li, F.3    Zhang, B.4    Qu, Y.5    Sun, T.6    Luo, T.7    Li, D.8
  • 25
    • 33747807016 scopus 로고    scopus 로고
    • Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats
    • Ahn, T., Yun, C.H., Oh, D.B., Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Toxicol. Lett. 166:1 (2006), 27–36.
    • (2006) Toxicol. Lett. , vol.166 , Issue.1 , pp. 27-36
    • Ahn, T.1    Yun, C.H.2    Oh, D.B.3
  • 26
    • 76749092673 scopus 로고    scopus 로고
    • Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells
    • Chen, M.L., Ip, S.P., Tsai, S.H., Ko, K.M., Che, C.T., Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells. J. Ethnopharmacol. 128:1 (2010), 116–122.
    • (2010) J. Ethnopharmacol. , vol.128 , Issue.1 , pp. 116-122
    • Chen, M.L.1    Ip, S.P.2    Tsai, S.H.3    Ko, K.M.4    Che, C.T.5
  • 27
    • 78049236043 scopus 로고    scopus 로고
    • CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophaghy in HepG2 E47 cells
    • Wu, D., Wang, X., Zhou, R., Cederbaum, A., CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophaghy in HepG2 E47 cells. Biochem. Biophys. Res. Commu. 402:1 (2010), 116–122.
    • (2010) Biochem. Biophys. Res. Commu. , vol.402 , Issue.1 , pp. 116-122
    • Wu, D.1    Wang, X.2    Zhou, R.3    Cederbaum, A.4
  • 28
    • 84895077533 scopus 로고    scopus 로고
    • Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes
    • Zhang, C.H., Yu, R.Y., Liu, Y.H., Tu, X.Y., Tu, J., Wang, Y.S., Xu, G.L., Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes. J. Ethnopharmacol. 151:2 (2014), 864–872.
    • (2014) J. Ethnopharmacol. , vol.151 , Issue.2 , pp. 864-872
    • Zhang, C.H.1    Yu, R.Y.2    Liu, Y.H.3    Tu, X.Y.4    Tu, J.5    Wang, Y.S.6    Xu, G.L.7
  • 29
    • 84879422237 scopus 로고    scopus 로고
    • Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1/Akt pathway
    • Koren-Gluzer, M., Aviram, M., Hayek, T., Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1/Akt pathway. Atherosclerosis 229:1 (2013), 71–78.
    • (2013) Atherosclerosis , vol.229 , Issue.1 , pp. 71-78
    • Koren-Gluzer, M.1    Aviram, M.2    Hayek, T.3
  • 30
    • 67349113398 scopus 로고    scopus 로고
    • Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes
    • Yao, H.T., Lin, P., Chang, Y.W., Chen, C.T., Chiang, M.T., Chang, L., Kuo, Y.C., Tsai, H.T., Yeh, T.K., Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Toxicology 47:7 (2009), 1703–1709.
    • (2009) Toxicology , vol.47 , Issue.7 , pp. 1703-1709
    • Yao, H.T.1    Lin, P.2    Chang, Y.W.3    Chen, C.T.4    Chiang, M.T.5    Chang, L.6    Kuo, Y.C.7    Tsai, H.T.8    Yeh, T.K.9
  • 31
    • 0027179792 scopus 로고
    • Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes
    • Shimojo, N., Ishizaki, T., Imaoka, S., Funae, Y., Fujii, S., Okuda, K., Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes. Biochem. Pharmacol. 46 (1993), 621–627.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 621-627
    • Shimojo, N.1    Ishizaki, T.2    Imaoka, S.3    Funae, Y.4    Fujii, S.5    Okuda, K.6
  • 32
    • 84883267259 scopus 로고    scopus 로고
    • Effects of orexin A on GLUT4 expression and lipid content via MAPK signaling in 3T3-L1 adipocytes
    • Shen, Y., Zhao, Y., Zheng, D., Chang, X., Ju, S., Guo, L., Effects of orexin A on GLUT4 expression and lipid content via MAPK signaling in 3T3-L1 adipocytes. J. Steroid Biochem. Mol. Biol. 138((2013), 376–383.
    • (2013) J. Steroid Biochem. Mol. Biol. , vol.138 , pp. 376-383
    • Shen, Y.1    Zhao, Y.2    Zheng, D.3    Chang, X.4    Ju, S.5    Guo, L.6
  • 33
    • 0026040907 scopus 로고
    • Development of muscle insulin resistance after liver insulin resistance in high-fat–fed rats
    • Kraegen, E.W., Clark, P.W., Jenkins, A.B., Daley, E.A., Chisholm, D.J., Storlien, L.H., Development of muscle insulin resistance after liver insulin resistance in high-fat–fed rats. Diabetes 40:11 (1991), 1397–1403.
    • (1991) Diabetes , vol.40 , Issue.11 , pp. 1397-1403
    • Kraegen, E.W.1    Clark, P.W.2    Jenkins, A.B.3    Daley, E.A.4    Chisholm, D.J.5    Storlien, L.H.6
  • 34
    • 84893820972 scopus 로고    scopus 로고
    • ABTS+ scavenging potency of selected flavonols from Hypericum perforatum L. by HPLC-ESI/MS QQQ: Reaction observation, adduct characterization and scavenging activity determination
    • Liu, Y.R., Li, W.G., Chen, L.F., Xiao, B.K., Yang, J.Y., Yang, L., Zhang, C.G., Huang, R.Q., Dong, J.X., ABTS+ scavenging potency of selected flavonols from Hypericum perforatum L. by HPLC-ESI/MS QQQ: Reaction observation, adduct characterization and scavenging activity determination. Food Res. Int. 58 (2014), 47–58.
    • (2014) Food Res. Int. , vol.58 , pp. 47-58
    • Liu, Y.R.1    Li, W.G.2    Chen, L.F.3    Xiao, B.K.4    Yang, J.Y.5    Yang, L.6    Zhang, C.G.7    Huang, R.Q.8    Dong, J.X.9
  • 35
    • 84872605803 scopus 로고    scopus 로고
    • Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays
    • López-Alarcón, C., Denicola, A., Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays. Anal. Chim. Acta 763 (2013), 1–10.
    • (2013) Anal. Chim. Acta , vol.763 , pp. 1-10
    • López-Alarcón, C.1    Denicola, A.2
  • 36
    • 0034861322 scopus 로고    scopus 로고
    • α-Glucosidase inhibitory action of natural acylated anthocyanins. 1. Survey of natural pigments with potent inhibitory activity
    • Matsui, T., Ueda, T., Oki, T., Sugita, K., Terahara, N., Matsumoto, K., α-Glucosidase inhibitory action of natural acylated anthocyanins. 1. Survey of natural pigments with potent inhibitory activity. J. Agric. Food Chem. 49:4 (2001), 1948–1951.
    • (2001) J. Agric. Food Chem. , vol.49 , Issue.4 , pp. 1948-1951
    • Matsui, T.1    Ueda, T.2    Oki, T.3    Sugita, K.4    Terahara, N.5    Matsumoto, K.6
  • 37
    • 84957429141 scopus 로고    scopus 로고
    • Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats
    • Ren, B., Qin, W., Wu, F., Wang, S., Pan, C., Wang, L., Zeng, B., Ma, S., Liang, J., Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. Eur. J. Pharmacol. 15:773 (2016), 13–23.
    • (2016) Eur. J. Pharmacol. , vol.15 , Issue.773 , pp. 13-23
    • Ren, B.1    Qin, W.2    Wu, F.3    Wang, S.4    Pan, C.5    Wang, L.6    Zeng, B.7    Ma, S.8    Liang, J.9
  • 38
    • 85016000826 scopus 로고    scopus 로고
    • In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw. on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes
    • Semaan, D.G., Igoli, J.O., Young, L., Marrero, E., Gray, A.I., Rowan, E.G., In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw. on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes. J. Ethnopharmacol. 5:203 (2017), 39–46.
    • (2017) J. Ethnopharmacol. , vol.5 , Issue.203 , pp. 39-46
    • Semaan, D.G.1    Igoli, J.O.2    Young, L.3    Marrero, E.4    Gray, A.I.5    Rowan, E.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.