Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial

Drug Research

Volumn 68, Issue 7, 2018, Pages 403-409

  Panahi, Yunes ^a   Khalili, Nahid ^a   Sahebi, Ebrahim ^b   Namazi, Soha ^b   Simental Mendía, Luis E ^c   Majeed, Muhammed ^d   Sahebkar, Amirhossein ^e,f  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^d SABINSA CORPORATION   (United States)

^e MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Curcuminoids; hepatic steatosis index; high sensitivity C reactive protein; homeostatic model assessments; type 2 diabetes mellitus

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; C PEPTIDE; C REACTIVE PROTEIN; CURCUMINOID DERIVATIVE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PIPERINE; PLACEBO; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; ALKALOID; AMIDE; ANTIOXIDANT; CURCUMIN; PIPERIDINE DERIVATIVE;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DIABETIC PATIENT; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; ADOLESCENT; BLOOD; DIETARY SUPPLEMENT; DRUG EFFECT; INFLAMMATION; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALANINE TRANSAMINASE; ALKALOIDS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BENZODIOXOLES; BIOMARKERS; BLOOD GLUCOSE; C-REACTIVE PROTEIN; CURCUMIN; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; OXIDATIVE STRESS; PIPERIDINES; POLYUNSATURATED ALKAMIDES; YOUNG ADULT;

EID: 85042212656     PISSN: 21949379     EISSN: 21949387     Source Type: Journal    
DOI: 10.1055/s-0044-101752     Document Type: Article

References (51)

1. Ganjali S. Blesso C. N. Banach M. et al. Effects of curcumin on HDL functionality. Pharmacological research: 2017; 119 208 218
2. Lelli D. Sahebkar A. Johnston T. P. et al. Curcumin use in pulmonary diseases: State of the art and future perspectives. Pharmacological research: 2017; 115 133 148
3. Mirzaei H. Naseri G. Rezaee R. et al. Curcumin: A new candidate for melanoma therapy? International journal of cancer: 2016; 139 1683 1695
4. Momtazi A. A. Shahabipour F. Khatibi S. et al. Curcumin as a MicroRNA regulator in cancer: A Review. Reviews of physiology, biochemistry and pharmacology: 2016; 171 1 38
5. Panahi Y. KP Mohtashami R. et al. Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial. Drug Res (Stuttg): 2017; 67 244 251
6. Panahi Y. Rahimnia A. R. Sharafi M. et al. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytotherapy research: PTR: 2014; 28 1625 1631
7. Rahmani S. Asgary S. Askari G. et al. Treatment of non-alcoholic fatty liver disease with curcumin: A randomized placebo-controlled trial. Phytotherapy research: PTR: 2016; 30 1540 1548
8. Saberi-Karimian M. Katsiki N. Caraglia M. et al. Vascular endothelial growth factor: An important molecular target of curcumin. Critical reviews in food science and nutrition: 2017; 1 14
9. Sahebkar A. Henrotin Y. Analgesic Efficacy and safety of curcuminoids in clinical practice: A systematic review and meta-analysis of randomized controlled trials. Pain medicine: 2016; 17 1192 1202
10. Chuengsamarn S. Rattanamongkolgul S. Luechapudiporn R. et al. Curcumin extract for prevention of type 2 diabetes. Diabetes care: 2012; 35 2121 2127
11. Na L. X. Li Y. Pan H. Z. et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial. Molecular nutrition & food research: 2013; 57 1569 1577
12. Hajavi J, MA Johnston TP et al. Curcumin: A naturally occurring modulator of adipokines in diabetes. J Cell Biochem 2017
13. Katsiki N. YJ Gotzamani-Psarrakou A. et al. Adipokines and vascular risk in type 2 diabetes mellitus. Angiology: 2011; 62 601 604
14. Wahlstrom B. Blennow G. A study on the fate of curcumin in the rat. Acta pharmacologica et toxicologica: 1978; 43 86 92
15. Shoba G. JD Joseph T. et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med: 1998; 64 353 356
16. Panahi Y. KN Sahebi E. et al. Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial. Inflammopharmacology: 2017; 25 25 31
17. Panahi Y. KN Sahebi E. et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial. Complement Ther Med: 2017; 33 1 5
18. Cicero AF G. Colletti A. Bajraktari G. et al. Lipid-lowering nutraceuticals in clinical practice: Position paper from an International Lipid Expert Panel. Nutrition reviews: 2017; 75 731 767
19. Cicero AF G. Colletti A. Bajraktari G. et al. Lipid lowering nutraceuticals in clinical practice: Position paper from an International Lipid Expert Panel. Archives of medical science:AMS: 2017; 13 965 1005
20. Johnston T. P. Korolenko T. A. Pirro M. et al. Preventing cardiovascular heart disease: Promising nutraceutical and non-nutraceutical treatments for cholesterol management. Pharmacological research: 2017; 120 219 225
21. Sahebkar A. Serban M. C. Gluba-Brzozka A. et al. Lipid-modifying effects of nutraceuticals: An evidence-based approach. Nutrition: 2016; 32 1179 1192
22. Ward N. Sahebkar A. Banach M. et al. Recent perspectives on the role of nutraceuticals as cholesterol-lowering agents. Current opinion in lipidology: 2017; 28 495 501
23. Cicero A. F. Colletti A. Role of phytochemicals in the management of metabolic syndrome. Phytomedicine: International journal of phytotherapy and phytopharmacology: 2016; 23 1134 1144
24. Sahebkar A. Curcuminoids for the management of hypertriglyceridaemia. Nature reviews Cardiology: 2014; 11 123
25. Granados-Castro L. F. R-RD Fernández-Rojas B. et al. Curcumin prevents paracetamol-induced liver mitochondrial alterations. J Pharm Pharmacol: 2016; 68 245 256
26. Naik S. R. TV Patil S. R. Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: Evidence of its antioxidant property. Exp Toxicol Pathol: 2011; 63 419 431
27. Yousef M. I. OS El-Guendi M. I. et al. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol: 2010; 48 3246 3261
28. Chuengsamarn S. RS Luechapudiporn R. et al. Curcumin extract for prevention of type 2 diabetes. Diabetes care: 2012; 35 2121 2127
29. Panahi Y. KN Hosseini M. S. et al. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial. Complement Ther Med: 2014; 22 851 857
30. Lee J. H. KD Kim H. J. et al. Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis: 2010; 42 503 508
31. Na L. X. LY Pan H. Z. et al. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial. Mol Nutr Food Res: 2013; 57 1569 1577
32. Fujiwara H. HM Zhou X. et al. Curcumin inhibits glucose production in isolated mice hepatocytes. Diabetes Res Clin Pract: 2008; 80 185 191
33. Seo K. I. CM Jung U. J. et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res: 2008; 52 995 1004
34. Hotamisligil G. S. PP Budavari A. et al. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science: 1996; 271 665 668
35. Naugler W. E. KM The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med: 2008; 14 109 119
36. Panahi Y. Alishiri G. H. Parvin S. et al. Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial. Journal of dietary supplements: 2016; 13 209 220
37. Panahi Y. Ghanei M. Hajhashemi A. et al. Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical symptoms and quality of life in subjects with chronic pulmonary complications due to sulfur mustard: A randomized controlled trial. Journal of dietary supplements: 2016; 13 93 105
38. Sahebkar A. Serban M. C. Ursoniu S. et al. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods: 2015; 18 898 909
39. Meghana K. SG Ramesh B. Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role. Eur J Pharmacol: 2007; 577 183 191
40. A.S Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother Res: 2014; 28 633 642
41. Panahi Y. HM Khalili N. et al. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin Nutr: 2015; 34 1101 1108
42. Lloyd-Jones D. M. LK Tian L. et al. Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease. Ann Intern Med: 2006; 145 35 42
43. Ganjali S. Sahebkar A. Mahdipour E. et al. Investigation of the effects of curcumin on serum cytokines in obese individuals: A randomized controlled trial. TheScientificWorldJournal: 2014; 2014 898361
44. Mollazadeh H. Cicero AF G. Blesso C. N. et al. Immune modulation by curcumin: The role of interleukin-10. Critical reviews in food science and nutrition: 2017; 1 13
45. Panahi Y. Hosseini M. S. Khalili N. et al. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clinical nutrition: 2015; 34 1101 1108
46. Sahebkar A. Cicero AF G. Simental-Mendia L. E. et al. Curcumin downregulates human tumor necrosis factor-alpha levels: A systematic review and meta-analysis ofrandomized controlled trials. Pharmacological research: 2016; 107 234 242
47. Moshage H. J. RH van Pelt J. F. et al. The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes. Biochem Biophys Res Commun: 1988; 155 112 117
48. Meng Z. YC Deng Q. et al. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacol Sin: 2013; 34 901 911
49. Leclercq I. A. FG Sempoux C. et al. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol: 2004; 41 926 934
50. Vizzutti F. PA Galastri S. et al. Curcumin limits the fibrogenic evolution of experimental steatohepatitis. Lab Invest: 2010; 90 104 115
51. Ramirez-Tortosa M. C. R-T C. Mesa M. D. et al. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic Biol Med: 2009; 47 924 931