Efficacy of modified atkins ketogenic diet in chronic cluster headache: An open-label, single-arm, clinical trial

Frontiers in Neurology

Volumn 9, Issue FEB, 2018, Pages

  Di Lorenzo, Cherubino ^a   Coppola, Gianluca ^b   Di Lenola, Davide ^c   Evangelista, Maurizio ^d   Sirianni, Giulio ^e   Rossi, Paolo ^f   Di Lorenzo, Giorgio ^g   Serrao, Mariano ^c   Pierelli, Francesco ^c,h  

^a IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^b IRCCS FONDAZIONE BIETTI   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

^e Wellness and Dietary Medicine   (Italy)

^f INI   (Italy)

^g UNIVERSITY OF ROME TOR VERGATA   (Italy)

^h IRCCS NEUROMED   (Italy)

Author keywords

Cluster headache; Drug resistance; Ketogenesis; Ketogenic diet; Ketone bodies; Modified Atkins diet

Indexed keywords

CARBOHYDRATE; LIPID; PROTEIN;

ADULT; ANALGESIA; ARTICLE; CARBOHYDRATE INTAKE; CHRONIC CLUSTER HEADACHE; CLINICAL ARTICLE; CLINICAL TRIAL; FAT INTAKE; FEMALE; HUMAN; KETOGENIC DIET; LIPID DIET; LOW CARBOHYDRATE DIET; MALE; MIDDLE AGED; MODIFIED ATKINS DIET; PROSPECTIVE STUDY; PROTEIN DIET; PROTEIN INTAKE;

EID: 85041923773     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2018.00064     Document Type: Article

References (15)

1. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia (2013) 33:629-808. doi:10.1177/0333102413485658
2. Di Lorenzo C, Coppola G, Di Lorenzo G, Bracaglia M, Rossi P, Pierelli F. The use of illicit drugs as self-medication in the treatment of cluster headache: results from an Italian online survey. Cephalalgia (2016) 36:194-8. doi:10.1177/0333102415583145
3. Di Lorenzo C, Coppola G, Sirianni G, Di Lorenzo G, Bracaglia M, Di Lenola D, et al. Migraine improvement during short lasting ketogenesis: a proof-of-concept study. Eur J Neurol (2015) 22:170-7. doi:10.1111/ene.12550
4. Di Lorenzo C, Coppola G, Bracaglia M, Di Lenola D, Evangelista M, Sirianni G, et al. Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study. J Headache Pain (2016) 17:58. doi:10.1186/s10194-016-0650-9
5. McDonald L. The Ketogenic Diet. Austin, TX: Lyle McDonald (1998)
6. Church WH, Adams RE, Wyss LS. Ketogenic diet alters dopaminergic activity in the mouse cortex. Neurosci Lett (2014) 571:1-4. doi:10.1016/j.neulet.2014.04.016
7. Lepper A, Frese A, Summ O, Nofer JR, Evers S. Hypothalamic dopaminergic stimulation in cluster headache. Cephalalgia (2013) 33:1155-9. doi:10.1177/0333102413487445
8. Di Lorenzo C, Coppola G, Pierelli F. A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. Cephalalgia (2013) 33:1272-6. doi:10.1177/0333102413490346
9. Coppola G, Di Lorenzo C, Bracaglia M, Di Lenola D, Parisi V, Perrotta A, et al. Lateralized nociceptive blink reflex habituation deficit in episodic cluster headache: correlations with clinical features. Cephalalgia (2015) 35:600-7. doi:10.1177/0333102414550418
10. Erecinska M, Nelson D, Daikhin Y, Yudkoff M. Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. J Neurochem (1996) 67:2325-34. doi:10.1046/j.1471-4159.1996.67062325.x
11. Khatami R, Tartarotti S, Siccoli MM, Bassetti CL, Sándor PS. Long-term efficacy of sodium oxybate in 4 patients with chronic cluster headache. Neurology (2011) 77:67-70. doi:10.1212/WNL.0b013e31822313c6
12. Hidalgo H, Uhl V, Gantenbein AR, Sándor PS, Kallweit U. Efficiency of sodium oxybate in episodic cluster headache. Headache (2013) 53:1490-1. doi:10.1111/head.12068
13. Cervenka MC, Henry BJ, Felton EA, Patton K, Kossoff EH. Establishing an adult epilepsy diet center: experience, efficacy and challenges. Epilepsy Behav (2016) 58:61-8. doi:10.1016/j.yebeh.2016.02.038
14. Leone M, Proietti Cecchini A. Deep brain stimulation in headache. Cephalalgia (2016) 36(12):1143-8. doi:10.1177/0333102415607176
15. Leone M, Proietti Cecchini A, Messina G, Franzini A. Long-term occipital nerve stimulation for drug-resistant chronic cluster headache. Cephalalgia (2017) 37:756-63. doi:10.1177/0333102416652623