Allostatic load but not medical burden predicts memory performance in late-life bipolar disorder

International Journal of Geriatric Psychiatry

Volumn 33, Issue 3, 2018, Pages 546-552

  Vaccarino, Sophie R ^a,b   Rajji, Tarek K ^a,b   Gildengers, Ariel G ^c   Waters, Sarah E S ^a,b   Butters, Meryl A ^c   Menon, Mahesh ^a,d   Blumberger, Daniel M ^a,b   Voineskos, Aristotle N ^a,b   Miranda, Dielle ^a,b   Mulsant, Benoit H ^a,b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

affective disorders; bipolar disorder; cognition; old age; physical health

Indexed keywords

ADULT; ALLOSTASIS; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; EXECUTIVE FUNCTION; FEMALE; HUMAN; INFORMATION PROCESSING; LANGUAGE ABILITY; MALE; MENTAL PERFORMANCE; PREDICTION; RECALL; VISUOMOTOR COORDINATION; AGED; CASE CONTROL STUDY; COGNITION; COGNITIVE DEFECT; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; REGRESSION ANALYSIS;

AGED; ALLOSTASIS; BIPOLAR DISORDER; CASE-CONTROL STUDIES; COGNITION; COGNITION DISORDERS; COGNITIVE DYSFUNCTION; COMORBIDITY; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; REGRESSION ANALYSIS;

EID: 85041714153     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.4829     Document Type: Article

References (43)

1. Whiteford HA, Degenhardt L, Rehm J et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet. 2013;382(9904):1575-1586.
2. Frias A, Palma C, Farriols N. Neurocognitive impairments among youth with pediatric bipolar disorder: a systematic review of neuropsychological research. J Affect Disord. 2014;166:297-306.
3. Gildengers AG, Butters MA, Chisholm D et al. Cognition in older adults with bipolar disorder versus major depressive disorder. Bipolar Disord. 2012;14(2):198-205.
4. Martinez-Aran A, Vieta E, Reinares M et al. Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. Am J Psychiatry. 2004;161(2):262-270.
5. Pavuluri MN, West A, Hill SK et al. Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths. J Am Acad Child Adolesc Psychiatry. 2009;48(3):299-307.
6. Quraishi S, Frangou S. Neuropsychology of bipolar disorder: a review. J Affect Disord. 2002;72(3):209-226.
7. Thompson JM, Gallagher P, Hughes JH et al. Neurocognitive impairment in euthymic patients with bipolar affective disorder. Br J Psychol. 2005;186:32-40.
8. Young RC, Murphy CF, Heo M et al. Cognitive impairment in bipolar disorder in old age: literature review and findings in manic patient. J Affect Disord. 2006;92(1):125-131.
9. Gildengers AG, Chisholm D, Butters MA et al. Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression? Psychol Med. 2013;43(4):801-811.
10. Martinez-Aran A, Vieta E, Colom F et al. Cognitive impairment in euthymic bioplar patients: implications for clinical and functional outcome. Bipolar Disord. 2004;6(3):224-232.
11. Pavuluri MN, Schenkel LS, Aryal S et al. Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients. Am J Psychiatry. 2006;163(2):286-293.
12. Robinson LJ, Thompson JM, Gallagher P et al. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord. 2006;93(1–3):105-115.
13. van Gorp WG, Altshuler L, Theberge DC et al. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence—a preliminary study. Arch Gen Psychiatry. 1998;55(1):41-46.
14. Biederman J, Petty CR, Wozniak J et al. Impact of executive function deficits in youth with bipolar I disorder: a controlled study. Psychiatry Res. 2011;186(1):58-64.
15. Gildengers AG, Mulsant BH, Begley A et al. The longitudinal course of cognition in older adults with bipolar disorder. Bipolar Disord. 2009;11(7):744-752.
16. Wingo AP, Harvey PD, Baldessarini RJ. Neurocognitive impairment in bipolar disorder patients: functional implications. Bipolar Disord. 2009;11(2):113-125.
17. Gildengers AG, Butters MA, Chisholm D et al. Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder. Am J Geriatr Psychiatry. 2007;15(2):174-179.
18. Gildengers AG, Whyte EM, Drayer RA et al. Medical burden in late-life bipolar and major depressive disorders. Am J Geriatr Psychiatry. 2008;16(3):194-200.
19. Sajatovic M, Forester BP, Gildengers A, Mulsant BH. Aging changes and medical complexity in late-life bipolar disorder: emerging research findings that may help advance care. Neuropsychiatry. 2013;3(6):621-633.
20. Kupfer DJ. The increasing medical burden in bipolar disorder. JAMA. 2005;293(20):2528-2530.
21. Brietzke E, Kapczinski F, Grassi-Oliveira R, Grande I, Vieta E, McIntyre RS. Insulin dysfunction and allostatic load in bipolar disorder. Expert Rev Neurother. 2011;11(7):1017-1028.
22. McIntyre RS, Konarski JZ, Misener VL, Kennedy SH. Bipolar disorder and diabetes mellitus: epidemiology, etiology, and treatment implications. Ann Clin Psychiatry. 2005;17(2):83-93.
23. Sylvia LG, Ametrano RM, Nierenberg AA. Exercise treatment for bipolar disorder: potential mechanisms of action mediated through increased neurogenesis and decreased allostatic load. Psychother Psychosom. 2010;79(2):87-96.
24. Muneer A. Bipolar disorder: role of inflammation and the development of disease biomarkers. Psychiatry Investig. 2016;13(1):18-33.
25. Kapczinski F, Vieta E, Andreazza AC et al. Allostatic load in bipolar disorder: implications for pathophysiology and treatment. Neurosci Biobehav Rev. 2008;32(4):675-692.
26. Kupfer DJ, Frank E, Ritchey FC. Staging bipolar disorder: what data and what models are needed? Lancet Psychiatry. 2015;2(6):564-570.
27. Vieta E, Popovic D, Rosa AR et al. The clinical implications of cognitive impairment and allostatic load in bipolar disorder. Eur Psychiatry. 2013;28(1):21-29.
28. McEwen BS, Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav. 2003;43(1):2-15.
29. Grande I, Magalhaes PV, Kunz M, Vieta E, Kapczinski F. Mediators of allostasis and systemic toxicity in bipolar disorder. Physiol Behav. 2012;106(1):46-50.
30. Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS. Price of adaptation—allostatic load and its health consequences—MacArthur studies of successful aging. Arch Intern Med. 1997;157(19):2259-2268.
31. Seeman TE, McEwen BS, Rowe JW, Singer BH. Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proc Natl Acad Sci U S A. 2001;98(8):4770-4775.
32. Bizik G, Picard M, Nijjar R et al. Allostatic load as a tool for monitoring physiological dysregulations and comorbidities in patients with severe mental illnesses. Harv Rev Psychiatry. 2013;21(6):296-313.
33. First MB. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition. New York: Biometrics Research, New York State Psychiatric Institute; 2002.
34. Hamilton MA. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6(4):278-296.
35. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133(5):429-435.
36. Wechsler D. Wechsler Test of Adult Reading. San Antonio, TX: Harcourt Assessment; 2001.
37. Miller MD et al. Rating chronic medical illness burden in geropsychiatric practice and research—application of the cumulative illness rating-scale. Psychiatry Res. 1992;41(3):237-248.
38. Truelsen T, Lindenstrom E, Boysen G. Comparison of probability of stroke between the Copenhagen-City-Heart-Study and the Framingham-Study. Stroke. 1994;25(4):802-807.
39. Wolf PA, Dagostino RB, Belanger AJ, Kannel WB. Probability of stroke—a risk profile from the Framingham-Study. Stroke. 1991;22(3):312-318.
40. Andreazza AC, Gildengers A, Rajji TK, Zuzarte PML, Mulsant BH, Young LT. Oxidative stress in older patients with bipolar disorder. Am J Geriatr Psychiatry. 2015;23(3):314-319.
41. Andreazza AC, Shao L, Wang JF, Young LT. Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch Gen Psychiatry. 2010;67(4):360-368.
42. Goldman N, Turra CM, Glei DA, Lin YH, Weinstein M. Physiological dysregulation and changes in health in an older population. Exp Gerontol. 2006;41(9):862-870.
43. Karlamangla AS, Singer BH, Seeman TE. Reduction in allostatic load in older adults is associated with lower all-cause mortality risk: MacArthur studies of successful aging. Psychosom Med. 2006;68(3):500-507.