2-Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells

Redox Biology

Volumn 15, Issue , 2018, Pages 441-451

  Bernhart, Eva ^a   Kogelnik, Nora ^a   Prasch, Jürgen ^a   Gottschalk, Benjamin ^a   Goeritzer, Madeleine ^a,b   Depaoli, Maria Rosa ^a   Reicher, Helga ^a   Nusshold, Christoph ^a   Plastira, Ioanna ^a   Hammer, Astrid ^a   Fauler, Günter ^a   Malli, Roland ^a,b   Graier, Wolfgang F ^a,b   Malle, Ernst ^a   Sattler, Wolfgang ^a,b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b BIOTECHMED GRAZ   (Austria)

Author keywords

Apoptosis; Blood brain barrier; Lipotoxicity; Myeloperoxidase; Neuroinflammation; Structured illumination microscopy

Indexed keywords

2 CHLOROHEXADECANOIC ACID; ADENOSINE TRIPHOSPHATE; ALKYNE; GSK 2606414; INTERLEUKIN 6; INTERLEUKIN 8; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PALMITIC ACID; PROCASPASE 3; PROTEIN SERINE THREONINE KINASE INHIBITOR; TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG; 2-CHLOROHEXADECANOIC ACID; 7-METHYL-5-(1-((3-(TRIFLUOROMETHYL)PHENYL)ACETYL)-2,3-DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO(2,3-D)PYRIMIDIN-4-AMINE; ADENINE; INDOLE DERIVATIVE; PALMITIC ACID DERIVATIVE; PERK KINASE; PEROXIDASE; PROTEIN KINASE R;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LIPOTOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSCRIPTION INITIATION; ANALOGS AND DERIVATIVES; APOPTOSIS; BRAIN; CELL LINE; DRUG EFFECT; ENDOTHELIUM CELL; GENETICS; LEUKOCYTE; METABOLISM; PATHOLOGY;

ADENINE; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIAL CELLS; HUMANS; INDOLES; INTERLEUKIN-8; LEUKOCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PALMITIC ACIDS; PEROXIDASE;

EID: 85041580979     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2018.01.003     Document Type: Article

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