11 C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11 C-(R)-PK11195

Journal of Cerebral Blood Flow and Metabolism

Volumn 38, Issue 3, 2018, Pages 393-403

  Kobayashi, Masato ^a   Jiang, Teresa ^a   Telu, Sanjay ^a   Zoghbi, Sami S ^a   Gunn, Roger N ^b,c   Rabiner, Eugenii A ^b   Owen, David R ^c   Guo, Qi ^b   Pike, Victor W ^a   Innis, Robert B ^a   Fujita, Masahiro ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b Imanova Ltd   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

18 kDa (TSPO); metabolite corrected arterial input; positron emission tomography; rs6971 polymorphism; XBD173

Indexed keywords

C11 DPA 713; CARRIER PROTEIN; EMAPUNIL; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; TRANSLOCATOR PROTEIN 18 KDA; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; ACETAMIDE DERIVATIVE; CARBON; CARBON-11; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N,N-DIETHYL-2-(2-(4-METHOXYPHENYL)-5,7-DIMETHYL-PYRAZOLO(1,5-A)PYRIMIDIN-3-YL)-ACETAMIDE; N-BENZYL-N-ETHYL-2-(7,8-DIHYDRO-7-METHYL-8-OXO-2-PHENYL-9H-PURIN-9-YL)ACETAMIDE; PROTEIN BINDING; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TSPO PROTEIN, HUMAN;

ADULT; ARTICLE; BRAIN; BRAIN SIZE; DRUG SCREENING; DYNAMICS; FEMALE; FUNCTIONAL NEUROIMAGING; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; NERVOUS SYSTEM INFLAMMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; BRAIN ARTERY; BRAIN CIRCULATION; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; GENETICS; METABOLISM; NORMAL HUMAN;

ACETAMIDES; ADULT; BRAIN; CARBON RADIOISOTOPES; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; FEMALE; HEALTHY VOLUNTEERS; HUMANS; ISOQUINOLINES; MALE; POLYMORPHISM, GENETIC; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PURINES; PYRAZOLES; PYRIMIDINES; RADIOPHARMACEUTICALS; RECEPTORS, GABA;

EID: 85041561873     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X17699223     Document Type: Article

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