-
1
-
-
62549115263
-
Multimodal approaches to the treatment of hepatocellular carcinoma
-
Cabibbo, G., Latteri, F., Antonucci, M. & Craxi, A. Multimodal approaches to the treatment of hepatocellular carcinoma. Nat. Clin. Pract. Gastroenterol. Hepatol. 6, 159-169 (2009).
-
(2009)
Nat. Clin. Pract. Gastroenterol. Hepatol
, vol.6
, pp. 159-169
-
-
Cabibbo, G.1
Latteri, F.2
Antonucci, M.3
Craxi, A.4
-
2
-
-
84891740035
-
Chemopreventive strategies in hepatocellular carcinoma
-
Singh, S., Singh, P. P., Roberts, L. R. & Sanchez, W. Chemopreventive strategies in hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 11, 45-54 (2014).
-
(2014)
Nat. Rev. Gastroenterol. Hepatol
, vol.11
, pp. 45-54
-
-
Singh, S.1
Singh, P.P.2
Roberts, L.R.3
Sanchez, W.4
-
3
-
-
84988416810
-
Reprogramming glucose metabolism in cancer: Can it be exploited for cancer therapy?
-
Hay, N. Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? Nat. Rev. Cancer 16, 635-649 (2016).
-
(2016)
Nat. Rev. Cancer
, vol.16
, pp. 635-649
-
-
Hay, N.1
-
4
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
Robey, R. B. & Hay, N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 25, 4683-4696 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
5
-
-
0038714272
-
Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function
-
Wilson, J. E. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J. Exp. Biol. 206, 2049-2057 (2003).
-
(2003)
J. Exp. Biol
, vol.206
, pp. 2049-2057
-
-
Wilson, J.E.1
-
6
-
-
84938835765
-
Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1
-
Guo, C. et al. Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1. Nat. Commun. 6, 6069 (2015).
-
(2015)
Nat. Commun
, vol.6
, pp. 6069
-
-
Guo, C.1
-
7
-
-
0037056002
-
Mitochondrial bound type II hexokinase: A key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention
-
Pedersen, P. L., Mathupala, S., Rempel, A., Geschwind, J. F. & Ko, Y. H. Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. Biochim. Biophys. Acta 1555, 14-20 (2002).
-
(2002)
Biochim. Biophys. Acta
, vol.1555
, pp. 14-20
-
-
Pedersen, P.L.1
Mathupala, S.2
Rempel, A.3
Geschwind, J.F.4
Ko, Y.H.5
-
8
-
-
84922071134
-
Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma
-
Guzman, G. et al. Evidence for heightened hexokinase II immunoexpression in hepatocyte dysplasia and hepatocellular carcinoma. Dig. Dis. Sci. 60, 420-426 (2015).
-
(2015)
Dig. Dis. Sci
, vol.60
, pp. 420-426
-
-
Guzman, G.1
-
9
-
-
84881557242
-
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
-
Patra, K. C. et al. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell. 24, 213-228 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 213-228
-
-
Patra, K.C.1
-
10
-
-
84878525884
-
Doxycycline alters metabolism and proliferation of human cell lines
-
Ahler, E. et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS ONE 8, e64561 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e64561
-
-
Ahler, E.1
-
11
-
-
0032890448
-
Chinese hamster ovary cells with reduced hexokinase activity maintain normal GDP-mannose levels
-
O'Rear, J. L., Scocca, J. R., Walker, B. K., Kaiden, A. & Krag, S. S. Chinese hamster ovary cells with reduced hexokinase activity maintain normal GDP-mannose levels. J. Cell Biochem. 72, 56-66 (1999).
-
(1999)
J. Cell Biochem
, vol.72
, pp. 56-66
-
-
O'Rear, J.L.1
Scocca, J.R.2
Walker, B.K.3
Kaiden, A.4
Krag, S.S.5
-
12
-
-
84924326053
-
Understanding the complex-I-ty of metformin action: Limiting mitochondrial respiration to improve cancer therapy
-
Luengo, A., Sullivan, L. B. & Heiden, M. G. Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy. BMC Biol. 12, 82 (2014).
-
(2014)
BMC Biol
, vol.12
, pp. 82
-
-
Luengo, A.1
Sullivan, L.B.2
Heiden, M.G.3
-
13
-
-
84905757105
-
Metformin-mode of action and clinical implications for diabetes and cancer
-
Pernicova, I. & Korbonits, M. Metformin-mode of action and clinical implications for diabetes and cancer. Nat. Rev. Endocrinol. 10, 143-156 (2014).
-
(2014)
Nat. Rev. Endocrinol
, vol.10
, pp. 143-156
-
-
Pernicova, I.1
Korbonits, M.2
-
14
-
-
21744459535
-
Regulation of mTOR and cell growth in response to energy stress by REDD1
-
Sofer, A., Lei, K., Johannessen, C. M. & Ellisen, L. W. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol. 25, 5834-5845 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 5834-5845
-
-
Sofer, A.1
Lei, K.2
Johannessen, C.M.3
Ellisen, L.W.4
-
15
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
Brugarolas, J. et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18, 2893-2904 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
-
16
-
-
0031852596
-
Further studies on the coupling of mitochondrially bound hexokinase to intramitochondrially compartmented ATP, generated by oxidative phosphorylation
-
Cesar, M. d. C. & Wilson J. E. Further studies on the coupling of mitochondrially bound hexokinase to intramitochondrially compartmented ATP, generated by oxidative phosphorylation. Arch. Biochem. Biophys. 350, 109-117 (1998).
-
(1998)
Arch. Biochem. Biophys
, vol.350
, pp. 109-117
-
-
Cesar, M.D.C.1
Wilson, J.E.2
-
17
-
-
84960893940
-
The nurture of tumors can drive their metabolic phenotype
-
Schug, Z. T., Vande Voorde, J. & Gottlieb, E. The nurture of tumors can drive their metabolic phenotype. Cell. Metab. 23, 391-392 (2016).
-
(2016)
Cell. Metab
, vol.23
, pp. 391-392
-
-
Schug, Z.T.1
Vande Voorde, J.2
Gottlieb, E.3
-
18
-
-
84863011452
-
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
-
Yuneva, M. O. et al. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell. Metab. 15, 157-170 (2012).
-
(2012)
Cell. Metab
, vol.15
, pp. 157-170
-
-
Yuneva, M.O.1
-
19
-
-
0030915085
-
Cloning and functional expression of a human liver organic cation transporter
-
Zhang, L. et al. Cloning and functional expression of a human liver organic cation transporter. Mol. Pharmacol. 51, 913-921 (1997).
-
(1997)
Mol. Pharmacol
, vol.51
, pp. 913-921
-
-
Zhang, L.1
-
20
-
-
79959764729
-
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
-
Ben Sahra, I. et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res. 71, 4366-4372 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 4366-4372
-
-
Ben Sahra, I.1
-
21
-
-
77955287742
-
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
-
Kalender, A. et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell. Metab. 11, 390-401 (2010).
-
(2010)
Cell. Metab
, vol.11
, pp. 390-401
-
-
Kalender, A.1
-
22
-
-
0027517726
-
53 tumor suppressor genes in human hepatoma cell lines
-
Puisieux, A. et al. Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J. 7, 1407-1413 (1993).
-
(1993)
FASEB J
, vol.7
, pp. 1407-1413
-
-
Puisieux, A.1
-
23
-
-
84960896869
-
Discovery of a novel 2,6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors
-
Lin, H. et al. Discovery of a novel 2,6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors. ACS Med. Chem. Lett. 7, 217-222 (2016).
-
(2016)
ACS Med. Chem. Lett
, vol.7
, pp. 217-222
-
-
Lin, H.1
-
24
-
-
84870668228
-
Parallel labeling experiments with [1,2-(13)C] glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism
-
Ahn, W. S. & Antoniewicz, M. R. Parallel labeling experiments with [1,2-(13)C] glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism. Metab. Eng. 15, 34-47 (2013).
-
(2013)
Metab. Eng
, vol.15
, pp. 34-47
-
-
Ahn, W.S.1
Antoniewicz, M.R.2
-
25
-
-
35348941242
-
Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis
-
Antoniewicz, M. R., Kelleher, J. K. & Stephanopoulos, G. Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Anal. Chem. 79, 7554-7559 (2007).
-
(2007)
Anal. Chem
, vol.79
, pp. 7554-7559
-
-
Antoniewicz, M.R.1
Kelleher, J.K.2
Stephanopoulos, G.3
-
26
-
-
0029664919
-
Correction of 13C mass isotopomer distributions for natural stable isotope abundance
-
Fernandez, C. A., Des Rosiers, C., Previs, S. F., David, F. & Brunengraber, H. Correction of 13C mass isotopomer distributions for natural stable isotope abundance. J. Mass Spectrom. 31, 255-262 (1996).
-
(1996)
J. Mass Spectrom
, vol.31
, pp. 255-262
-
-
Fernandez, C.A.1
Des Rosiers, C.2
Previs, S.F.3
David, F.4
Brunengraber, H.5
-
27
-
-
51049091904
-
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line
-
Yoo, H., Antoniewicz, M. R., Stephanopoulos, G. & Kelleher, J. K. Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J. Biol. Chem. 283, 20621-20627 (2008).
-
(2008)
J. Biol. Chem
, vol.283
, pp. 20621-20627
-
-
Yoo, H.1
Antoniewicz, M.R.2
Stephanopoulos, G.3
Kelleher, J.K.4
-
28
-
-
84939420225
-
(13)C-metabolic flux analysis of co-cultures: A novel approach
-
Gebreselassie, N. A. & Antoniewicz, M. R. (13)C-metabolic flux analysis of co-cultures: a novel approach. Metab. Eng. 31, 132-139 (2015).
-
(2015)
Metab. Eng
, vol.31
, pp. 132-139
-
-
Gebreselassie, N.A.1
Antoniewicz, M.R.2
-
29
-
-
84971673738
-
Evidence for transketolase-like TKTL1 flux in CHO cells based on parallel labeling experiments and (13)C-metabolic flux analysis
-
Ahn, W. S., Crown, S. B. & Antoniewicz, M. R. Evidence for transketolase-like TKTL1 flux in CHO cells based on parallel labeling experiments and (13)C-metabolic flux analysis. Metab. Eng. 37, 72-78 (2016).
-
(2016)
Metab. Eng
, vol.37
, pp. 72-78
-
-
Ahn, W.S.1
Crown, S.B.2
Antoniewicz, M.R.3
-
30
-
-
33745155105
-
Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements
-
Antoniewicz, M. R., Kelleher, J. K. & Stephanopoulos, G. Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab. Eng. 8, 324-337 (2006).
-
(2006)
Metab. Eng
, vol.8
, pp. 324-337
-
-
Antoniewicz, M.R.1
Kelleher, J.K.2
Stephanopoulos, G.3
-
31
-
-
84961219443
-
Spontaneous hepatocellular carcinoma after the combined deletion of Akt isoforms
-
Wang, Q. et al. Spontaneous hepatocellular carcinoma after the combined deletion of Akt isoforms. Cancer Cell 29, 523-535 (2016).
-
(2016)
Cancer Cell
, vol.29
, pp. 523-535
-
-
Wang, Q.1
|