Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

ACS Medicinal Chemistry Letters

Volumn 7, Issue 3, 2016, Pages 217-222

  Lin, Hong ^a   Zeng, Jin ^a   Xie, Ren ^a   Schulz, Mark J ^a   Tedesco, Rosanna ^a   Qu, Junya ^a   Erhard, Karl F ^a   MacK, James F ^a   Raha, Kaushik ^a   Rendina, Alan R ^a   Szewczuk, Lawrence M ^a   Kratz, Patricia M ^a   Jurewicz, Anthony J ^a   Cecconie, Ted ^a   Martens, Stan ^a   McDevitt, Patrick J ^a   Martin, John D ^a   Chen, Stephenie B ^a   Jiang, Yong ^a   Nickels, Leng ^a   Schwartz, Benjamin J ^a   Smallwood, Angela ^a   Zhao, Baoguang ^a   Campobasso, Nino ^a   Qian, Yanqiu ^a   Briand, Jacques ^a   Rominger, Cynthia M ^a   Oleykowski, Catherine ^a   Hardwicke, Mary Ann ^a   Luengo, Juan I ^a   more..

^a GLAXOSMITHKLINE   (United States)

Author keywords

crystal structure; Hexokinase 2 inhibitor; structure activity relationship selectivity

Indexed keywords

GLUCOSAMINE DERIVATIVE; GLUCOSE; LACTIC ACID;

ARTICLE; BLADDER TUMOR; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CULTURE; CONFORMATION; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; GLYCOLYSIS; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

EID: 84960896869     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00214     Document Type: Article

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