THC alters alters morphology of neurons in medial prefrontal cortex, orbital prefrontal cortex, and nucleus accumbens and alters the ability of later experience to promote structural plasticity

Synapse

Volumn 72, Issue 3, 2018, Pages

  Kolb, Bryan ^a,b   Li, Yilin ^a   Robinson, Terry ^c   Parker, Linda A ^d  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

^b CANADIAN INSTITUTE FOR ADVANCED RESEARCH   (Canada)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF GUELPH   (Canada)

Author keywords

D9 THC; dendrite; enriched environment; golgi cox; neuroplasticity; spines

Indexed keywords

DRONABINOL; PSYCHOSTIMULANT AGENT; PSYCHOTROPIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ANALYSIS; BRAIN NERVE CELL; CELL DENSITY; CELL STRUCTURE; CHEMICAL INTERACTION; CONTROLLED STUDY; DENDRITE; DRUG EFFECT; DRUG EXPOSURE; GOLGI STAIN; LOCOMOTION; LONG EVANS RAT; LONG TERM EXPOSURE; MALE; MEDIAL PREFRONTAL CORTEX; NERVE CELL GROWTH; NERVE CELL PLASTICITY; NERVE STIMULATION; NONHUMAN; NUCLEUS ACCUMBENS; ORBITAL PREFRONTAL CORTEX; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; ANIMAL; ANIMAL HOUSING; CHEMICALLY INDUCED; COGNITIVE DEFECT; ENVIRONMENT; MOTOR ACTIVITY; NERVE CELL; PATHOLOGY; PHYSIOLOGY;

ANIMALS; COGNITIVE DYSFUNCTION; DRONABINOL; ENVIRONMENT; HOUSING, ANIMAL; MALE; MOTOR ACTIVITY; NEURONAL PLASTICITY; NEURONS; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PSYCHOTROPIC DRUGS; RATS, LONG-EVANS;

EID: 85041139411     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.22020     Document Type: Article

References (31)

1. Arnold, J. C., Topple, A. N., Hunt, G. E., & McGregor, I. S. (1998). Effects of preexposure and co-administration of the cannabinoid receptor agonist CP 55,940 on behavioral sensitization to cocaine. European Journal of Pharmacology, 354, 9–16.
2. Battistella, G., Fornari, E., Annoni, J.-M., Chitoui, H., Dao, K., Fabritius, M., … Giroud, C. (2014). Long-term effects of cannabis on brain structure. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 39, 2041–2048.
3. Behan, A. T., Hryniewiecka, M., O'tuathaigh, C. M., Kinsella, A., Cannon, M., Karayiorgou, M., … Cotter, D. R. (2012). Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways. Neuropsychopharmacol, 37, 1773–1783.
4. Bennett, E. L., Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1964). Chemical and anatomical plasticity of the brain. Science (New York, N.Y.), 146, 610–619.
5. Churchwell, J. C., Lopez-Larson, M., & Yurgelun-Todd, D. A. (2010). Altered frontal cortical volume and decision making in adolescent cannabis users. Frontiers in Psychology, 1, 225.
6. Dong, Y., & Nestler, E. J. (2014). The neural rejuvenation hypothesis of cocaine addiction. Trends in Pharmacological Sciences, 35, 374–383.
7. Ellgren, M., Hurd, Y. L., & Franck, J. (2004). Amphetamine effects on dopamine levels and behavior following cannabinoid exposure during adolescence. European Journal of Pharmacology, 497, 205–213.
8. Gardner, E. L., & Lowinson, J. H. (1991). Marijuana's interaction with brain reward systems: Update. Pharmacology, Biochemistry, and Behavior, 40, 571–580.
9. Gibb, R., & Kolb, B. (1998). A method for vibratome sectioning of Golgi-Cox stained whole rat brain. Journal of Neuroscience Methods, 79, 1–4.
10. Hamilton, D., & Kolb, B. (2005). Nicotine, experience, and brain plasticity. Behavioral Neuroscience, 119, 355–365.
11. Himmler, B. T., Mychasiuk, R., Nakahashi, A., Himmler, S. M., Pellis, S. M., & Kolb, B. Juvenile social experience and differential age-related changes in the dendritic morphologies of subareas of the prefrontal cortex in rats. In submission.
12. Kolb, B., Forgie, M., Gibb, R., Gorny, G., & Rowntree, S. (1998). Age, experience, and the changing brain. Neuroscience and Biobehavioral Reviews, 22, 143–159.
13. Kolb, B., Gibb, R., & Gorny, G. (2003c). Experience-dependent changes in dendritic arbor and spine density in neocortex vary with age and sex. Neurobiology of Learning and Memory, 791, 1–10.
14. Kolb, B., Gorny, G., Li, Y., Samaha, A. N., & Robinson, T. E. (2003a). Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America, 100, 10523–10528.
15. Kolb, B., Gorny, G., Limebeer, C. L., & Parker, L. A. (2006). Chronic treatment with Delta-9-tetrahydrocannabinol alters the structure of neurons in the nucleus accumbens shell and medial prefrontal cortex of rats. Synapse (New York, N.Y.), 60, 429–436.
16. Kolb, B., Gorny, G., Sonderpalm, A., & Robinson, T. E. (2003b). Environmental complexity has different effects on the structure of neurons in the prefrontal cortex versus the parietal cortex or nucleus accumbens. Synapse (New York, N.Y.), 48, 149–153.
17. Lawston, J., Borella, A., Robinson, J. K., & Whitaker-Azmitia, P. M. (2000). Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55, 212-2. Brain Research, 877, 407–410.
18. Muschamp, J. W., & Siviy, S. M. (2002). Behavioral sensitization to amphetamine follows chronic administration of the CB1 agonist WIN 55, 212-2 in Lewis rats. Pharmacology, Biochemistry and Behavior, 73, 835–842.
19. Mychasiuk, R., Muhammad, A., Ilnytsky, S., & Kolb, B. (2013). Persistent gene expression changes in NAc, mPFC, and OFC associated with previous nicotine or amphetamine exposure. Behavioural Brain Research, 256, 655–651.
20. Mychasiuk, R., Muhammad, A., & Kolb, B. (2014). Environmental enrichment alters structural plasticity of the adolescent brain but does not remediate the effects of prenatal nicotine exposure. Synapse, 68, 293–305.
21. Orr, J. M., Paschall, C. J., & Banich, M. T. (2016). Recreational marijuana use impacts white matter integrity and subcortical (but not cortical) morphometry. NeuroImage. Clinical, 12, 47–56.
22. Rampon, C., Jiang, C. H., Dong, H., Tang, Y.-P., Lockhart, D. J., Schultz, P. G., … Hu, Y. (2000). Effects of environmental enrichment on gene expression in the brain. Proceedings of the National Academy of Sciences of the United States of America, 97, 12880–12884.
23. Robinson, T. E., & Kolb, B. (2004). Structural plasticity associated with drugs of abuse. Neuropharmacology, 47 Suppl 1, 33–46.
24. Robison, A. J., & Nestler, E. J. (2011). Transciptional and epigenetic mechanisms of addiction. Nature Review Neuroscience, 12, 623–637
25. Sañudo-Peña, M. C., Romero, J., Seale, G. E., Fernandez-Ruiz, J. J., & Walker, J. M. (2000). Activational role of cannabinoids on movement. European Journal of Pharmacology, 391, 269–274.
26. Scallet, A. C., Uemura, E., Andrews, A., Ali, S. F., McMillan, D. E., Paule, M. G., … Slikker, W. Jr. (1987). Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC). Brain Research, 436, 193–198.
27. Sirevaag, A. M., & Greenough, W. T. (1987). Differntial rearing effects on rat visual cortex synapses. III. Neuronal and glial nuclei, boutons, dendrites, and capillaries. Brain Research, 424, 320–332.
28. Sirevaag, A. M., & Greenough, W. T. (1988). A multivariate statistical summary of synaptic plasticity measures in rats exposed to complex, social and individual environments. Brain Research, 441, 386–392.
29. Spiga, S., Lintas, A., Migliore, M., & Diana, M. (2010). Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. Addiction Biology, 15, 266–276.
30. Van Praag, H., Kempermann, G., & Gage, F. H. (2000). Neural consequences of environmental enrichment. Nature Reviews. Neuroscience, 1, 191–196.
31. Weiland, B. J., Thayer, R. E., Depue, B. E., Sabbineni, A., Bryan, A. D., & Hutchison, K. E. (2015). Daily marijuana use is not associated with brain morphometric measures in adolescents or adults. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 35, 1505–1512.