Microbial regulation of the L cell transcriptome

Scientific Reports

Volumn 8, Issue 1, 2018, Pages

  Arora, Tulika ^a,b   Akrami, Rozita ^a   Pais, Ramona ^c   Bergqvist, Linda ^a   Johansson, Bengt R ^d   Schwartz, Thue W ^b   Reimann, Frank ^c   Gribble, Fiona M ^c   Bäckhed, Fredrik ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Capital Region   (Denmark)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; TRANSCRIPTOME;

ANIMAL; BIOLOGY; ENTEROENDOCRINE CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GENETICS; HOST PATHOGEN INTERACTION; INTESTINE FLORA; METABOLISM; MICROBIOLOGY; MICROFLORA; MOUSE; PROCEDURES; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALS; COMPUTATIONAL BIOLOGY; ENTEROENDOCRINE CELLS; GASTROINTESTINAL MICROBIOME; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GLUCAGON-LIKE PEPTIDE 1; HOST-PATHOGEN INTERACTIONS; MICE; MICE, TRANSGENIC; MICROBIOTA; TRANSCRIPTOME;

EID: 85040811485     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-18079-2     Document Type: Article

References (35)

1. Tremaroli, V., & Backhed, F. Functional interactions between the gut microbiota and host metabolism. Nature 489, 242-249 (2012).
2. Schroeder, B. O., & Backhed, F. Signals from the gut microbiota to distant organs in physiology and disease. Nat Med 22, 1079-1089 (2016).
3. Sommer, F., & Backhed, F. The gut microbiota-masters of host development and physiology. Nat Rev Microbiol 11, 227-238 (2013).
4. Sommer, F., & Backhed, F. Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology. Bioessays 38, 455-464 (2016).
5. Sternini, C., Anselmi, L., & Rozengurt, E. Enteroendocrine cells: a site of ?taste? in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes 15, 73-78 (2008).
6. Gribble, F. M., & Reimann, F. Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium. Annu Rev Physiol 78, 277-299 (2016).
7. Drucker, D. J., et al. Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits. Diabetes Care 33, 428-433 (2010).
8. Tolhurst, G., Reimann, F., & Gribble, F. M. Nutritional regulation of glucagon-like peptide-1 secretion. J Physiol 587, 27-32 (2009).
9. Tolhurst, G., et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 61, 364-371 (2012).
10. Brighton, C. A., et al. Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors. Endocrinology 156, 3961-3970 (2015).
11. Cani, P. D., Hoste, S., Guiot, Y., & Delzenne, N. M. Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 98, 32-37 (2007).
12. Delmee, E., et al. Relation between colonic proglucagon expression and metabolic response to oligofructose in high fat diet-fed mice. Life Sci 79, 1007-1013 (2006).
13. Wichmann, A., et al. Microbial modulation of energy availability in the colon regulates intestinal transit. Cell Host Microbe 14, 582-590 (2013).
14. Donohoe, D. R., et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab 13, 517-526 (2011).
15. Reimann, F., et al. Glucose sensing in L cells: a primary cell study. Cell Metab 8, 532-539 (2008).
16. Richards, P., et al. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides 77, 21-27 (2016).
17. Stappenbeck, T. S., Hooper, L. V., & Gordon, J. I. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci USA 99, 15451-15455 (2002).
18. Kelly, J. R., et al. Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci 9, 392 (2015).
19. Hooper, L. V., Littman, D. R., & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268-1273 (2012).
20. Larsson, E., et al. Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88. Gut 61, 1124-1131 (2012).
21. Sommer, F., Nookaew, I., Sommer, N., Fogelstrand, P., & Backhed, F. Site-specific programming of the host epithelial transcriptome by the gut microbiota. Genome Biol 16, 62 (2015).
22. Johansson, M. E., et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA 105, 15064-15069 (2008).
23. Bohorquez, D. V., et al. Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. J Clin Invest 125, 782-786 (2015).
24. Arvidsson, C., Hallen, A., & Backhed, F. Generating and Analyzing Germ-Free Mice. Curr Protoc Mouse Biol 2, 307-316 (2012).
25. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria (2015).
26. JW, M. mogene20sttranscriptcluster.db: Affymetrix mogene20 annotation data (chip mogene20sttranscriptcluster). R package version 8.2.0.
27. Lance, G. N., & Williams, W. T. Mixed-data classificatory programs. I. Agglomerative Systems. Australian Computer Journal 15-20 (1967).
28. Murtagh, F., & Legendre, P. Ward?s Hierarchical Agglomerative Clustering Method: Which Algorithms Implement Ward?s Criterion? Journal of Classification 31, 274-295 (2014).
29. Ritchie, M. E., et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43, e47 (2015).
30. Yu, G., Wang, L. G., Han, Y., & He, Q. Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16, 284-287 (2012).
31. Carlson, M.org.Mm.eg.db: Genome wide annotation for Mouse. R package version 3.4.1 (2017).
32. Benjamini, Y., & Hochberg, Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society. Series B (Methodological) 289-300 (1995).
33. Hanbo, C. VennDiagram: Generate high-resolution Venn and Euler plots. R package version 1.6.9. http://CRAN.R-project.org/package=VennDiagram (2014).
34. Wickham, H. ggplot2: elegant graphics for data analysis. 1 edn, (Springer-Verlag New York, 2009).
35. Walter, W., Sanchez-Cabo, F., & Ricote, M. GOplot: an R package for visually combining expression data with functional analysis. Bioinformatics 31, 2912-2914 (2015).