Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design

ChemMedChem

Volumn 13, Issue 3, 2018, Pages 241-250

  Axer, Alexander ^a   Hermann, Sven ^a,b   Kehr, Gerald ^a   Clases, David ^a   Karst, Uwe ^a   Fischer Riepe, Lena ^a   Roth, Johannes ^a,b   Fobker, Manfred ^a   Schäfers, Michael ^a,b   Gilmour, Ryan ^a   Faust, Andreas ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

carbohydrates; imaging agents; inflammation; radiopharmaceuticals; technetium

Indexed keywords

AAX 21; AAX 31; AAX 32; ALPHA GLUCOSIDASE; AMYLASE; ENZYME; FLUORODEOXYGLUCOSE F 18; MALTODEXTRIN; MALTODEXTRIN F 18; MALTOHEXAOSE F 18; MALTOPENTAOSE F 18; MALTOSE BINDING PROTEIN; MALTOTRIOSE F 18; MB 1143; MB 1143 TC 99M; STARCH DEGRADING ENZYME; TRACER; UNCLASSIFIED DRUG; CONTRAST MEDIUM; MALTOHEXAOSE; OLIGOSACCHARIDE; POLYSACCHARIDE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BACTERIAL METABOLISM; BACTERIUM DETECTION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG UPTAKE; ENZYME ACTIVITY; FOOT PAD; HUMAN; IN VIVO STUDY; INFLAMMATION; ISOTOPE LABELING; MOLECULAR IMAGING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOCHEMISTRY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SUBSTITUTION REACTION; THIN LAYER CHROMATOGRAPHY; TRANSPORT KINETICS; URINARY EXCRETION; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DIAGNOSTIC IMAGING; METABOLISM; OXIDATION REDUCTION REACTION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; CONTRAST MEDIA; FLUORODEOXYGLUCOSE F18; HUMANS; ISOTOPE LABELING; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; OLIGOSACCHARIDES; OXIDATION-REDUCTION; POLYSACCHARIDES; RADIOPHARMACEUTICALS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TECHNETIUM; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 85040619787     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201700543     Document Type: Article

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