Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design

Science

Volumn 359, Issue 6373, 2018, Pages 290-296

  Du, Yushen ^a,b   Xin, Li ^c   Shi, Yuan ^a   Zhang, Tian Hao ^a,d   Wu, Nicholas C ^d   Dai, Lei ^a   Gong, Danyang ^a   Brar, Gurpreet ^a   Shu, Sara ^a   Luo, Jiadi ^a,e,f   Reiley, William ^g   Tseng, Yen Wen ^a   Bai, Hongyan ^c   Wu, Ting Ting ^a   Wang, Jieru ^a,e   Shu, Yuelong ^c,h   Sun, Ren ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c BEIJING HOSPITAL   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f CENTRAL SOUTH UNIVERSITY   (China)

^g TRUDEAU INSTITUTE   (United States)

^h SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; HERMES ANTIGEN; INFLUENZA VACCINE; INTERFERON; INTERLEUKIN 7 RECEPTOR; L SELECTIN;

GENOME; GENOMICS; HOMOLOGY; IMITATION; IMMUNE RESPONSE; INFLUENZA; PATHOGEN; PROTEIN; VACCINE;

ADAPTIVE IMMUNITY; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE RESPONSE; DRUG DESIGN; GENE IDENTIFICATION; GENE MUTATION; GENOME-WIDE ASSOCIATION STUDY; HIGH THROUGHPUT SEQUENCING; HUMAN; IN VITRO STUDY; INFLUENZA A VIRUS; INFLUENZA VACCINATION; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; VIRUS REPLICATION; ANIMAL; DRUG EFFECT; GENETICS; IMMUNOLOGY; INFLUENZA; MOUSE; MUSTELA PUTORIUS FURO; MUTATION; ORTHOMYXOVIRUS INFECTION; REPRODUCTIVE FITNESS; VACCINE IMMUNOGENICITY; VIRUS GENOME;

INFLUENZA A VIRUS;

ANIMALS; FERRETS; GENETIC FITNESS; GENOME, VIRAL; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNITY, CELLULAR; IMMUNOGENICITY, VACCINE; INFLUENZA A VIRUS; INFLUENZA VACCINES; INFLUENZA, HUMAN; INTERFERONS; MICE; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; VIRUS REPLICATION;

EID: 85040570901     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aan8806     Document Type: Article

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