Genetic variations in NF-κB were associated with the susceptibility to hepatitis C virus infection among Chinese high-risk population

Scientific Reports

Volumn 8, Issue 1, 2018, Pages

  Tian, Ting ^a,b   Wang, Jie ^a   Huang, Peng ^a   Li, Jun ^c   Yu, Rongbin ^a   Fan, Haozhi ^a,b   Xia, Xueshan ^d   Han, Yaping ^c   Zhang, Yun ^b   Yue, Ming ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Huadong Research Institute for Medicine and Biotechnics   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; VIRUS RNA;

ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; BIOLOGY; CHINA; CONFORMATION; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOTYPE; HAPLOTYPE; HEPACIVIRUS; HEPATITIS C; HUMAN; MALE; MUTATION; NUCLEOTIDE SEQUENCE; ODDS RATIO; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSMISSION; VIROLOGY;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CHINA; COMPUTATIONAL BIOLOGY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HAPLOTYPES; HEPACIVIRUS; HEPATITIS C; HUMANS; MALE; MUTATION; NF-KAPPA B; NUCLEIC ACID CONFORMATION; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, VIRAL;

EID: 85040450883     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-18463-y     Document Type: Article

References (38)

1. Kao, J. H. et al. Urgency to treat patients with chronic hepatitis C in Asia. Journal of gastroenterology and hepatology 32, 966-974 (2017).
2. Cox, A. L. Global control of hepatitis C virus. Science 349, 790-791 (2015).
3. Hoshida, Y., Fuchs, B. C., Bardeesy, N., Baumert, T. F. & Chung, R. T. Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma. Journal of hepatology 61, S79-S90 (2014).
4. European Association for the Study of the Liver. EASL Recommendations on Treatment of Hepatitis C 2016. Journal of hepatology 66, 153 (2017).
5. Omata, M. et al. APASL consensus statements and recommendations for hepatitis C prevention, epidemiology, and laboratory testing. Hepatology international 10, 681-701 (2016).
6. Bowie, A. & O'Neill, L. A. Oxidative stress and nuclear factor-?B activation: a reassessment of the evidence in the light of recent discoveries. Biochemical pharmacology 59, 13-23 (2000).
7. Wietek, C. & O'Neill, L. A. Diversity and regulation in the NF-?B system. Trends in biochemical sciences 32, 311-319 (2007).
8. Li, Q. & Verma, I. M. NF-[kappa] B regulation in the immune system. Nature reviews. Immunology 2, 725-734 (2002).
9. O'Neill, L. A. & Bowie, A. G. Sensing and signaling in antiviral innate immunity. Current Biology 20, R328-R333 (2010).
10. Miggin, S. M. et al. NF-?B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proceedings of the National Academy of Sciences 104, 3372-3377 (2007).
11. Park, M. H. & Hong, J. T. Roles of NF-?B in cancer and inflammatory diseases and their therapeutic approaches. Cells 5, 15 (2016).
12. Bowie, A. G. & Unterholzner, L. Viral evasion and subversion of pattern-recognition receptor signalling. Nature reviews. Immunology 8, 911-922 (2008).
13. O'Brown, Z. K., Van Nostrand, E. L., Higgins, J. P. & Kim, S. K. The inflammatory transcription factors NF?B, STAT1 and STAT3 drive age-associated transcriptional changes in the human kidney. PLoS genetics 11, e1005734 (2015).
14. Hashimoto, R. et al. Variants of the RELA gene are associated with schizophrenia and their startle responses. Neuropsychopharmacology 36, 1921-1931 (2011).
15. Gao, J. et al. Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case-control study in Shanghai, China. BMJ open 4, e004427 (2014).
16. Edenberg, H. J. et al. Association of NFKB1, which encodes a subunit of the transcription factor NF-?B, with alcohol dependence. Human molecular genetics 17, 963-970 (2008).
17. Du, J. et al. Polymorphisms of NF-?B family genes are associated with development of multiple myeloma and treatment outcome in patients undergoing bortezomib-based regimens. Haematologica 96, 729-737 (2011).
18. Leung, G. et al. Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery. Lymphatic research and biology 12, 10-22 (2014).
19. Byun, E. et al. Cytokine polymorphisms are associated with daytime napping in adults living with HIV. Sleep Medicine 32, 162-170 (2017).
20. Aouizerat, B. E. et al. Phenotypic and molecular evidence suggests that decrements in morning and evening energy are distinct but related symptoms. Journal of pain and symptom management 50, 599-614. e3 (2015).
21. Bhattacherjee, V. et al. Use of NS-4 peptides to identify type-specific antibody to hepatitis C virus genotypes 1, 2, 3, 4, 5 and 6. Journal of General Virology 76, 1737-1748 (1995).
22. Yue, M. et al. Toll-like receptor 7 variations are associated with the susceptibility to HCV infection among Chinese females. Infection, Genetics and Evolution 27, 264-270 (2014).
23. Yue, M. et al. Sex-specific association between X-linked Toll-like receptor 7 with the outcomes of hepatitis C virus infection. Gene 548, 244-250 (2014).
24. Yue, M. et al. Association of interleukin-18 gene polymorphisms with the outcomes of hepatitis C virus infection in high-risk Chinese Han population. Immunology letters 154, 54-60 (2013).
25. Yue, M. et al. Human leukocyte antigen class II alleles are associated with hepatitis C virus natural susceptibility in the Chinese population. International journal of molecular sciences 16, 16792-16805 (2015).
26. Xu, X. et al. Genetic variants in human leukocyte antigen-DP influence both hepatitis C virus persistence and hepatitis C virus F protein generation in the Chinese Han population. International journal of molecular sciences 15, 9826-9843 (2014).
27. Wu, M.-p et al. Genetic variations in vitamin D receptor were associated with the outcomes of hepatitis C virus infection among Chinese population. Journal of human genetics 61, 129-135 (2016).
28. Tang, S. et al. Association of genetic variants in estrogen receptor ? with HCV infection susceptibility and viral clearance in a highrisk Chinese population. European journal of clinical microbiology & infectious diseases 33, 999-1010 (2014).
29. Cheng, C.-W. et al. Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features. PLoS One 8, e56130 (2013).
30. Yu, Y. et al. The joint association of REST and NFKB1 polymorphisms on the risk of colorectal cancer. Annals of human genetics 76, 269-276 (2012).
31. Fakhir, F.-Z. et al. The-94Ins/DelATTG polymorphism in NF?B1 promoter modulates chronic hepatitis C and liver disease progression. Infection, Genetics and Evolution 39, 141-146 (2016).
32. Bowes, J. et al. Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort. Annals of the rheumatic diseases 71, 1350-1354 (2012).
33. Daley, D. et al. Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes. Journal of Allergy and Clinical Immunology 130, 1284-1293 (2012).
34. Chorev, M. & Carmel, L. The function of introns. Front genet 3, 1-15 (2012).
35. Damgaard, C. K. et al. A 5? splice site enhances the recruitment of basal transcription initiation factors in vivo. Molecular cell 29, 271-278 (2008).
36. Seeff, L. B. Natural history of chronic hepatitis C. Hepatology 36, S35-S46 (2002).
37. Fish, E. N. The X-files in immunity: sex-based differences predispose immune responses. Nature reviews. Immunology 8, 737-744 (2008).
38. Cui, Y. & Jia, J. Update on epidemiology of hepatitis B and C in China. Journal of gastroenterology and hepatology 28, 7-10 (2013).