Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 6, 2012, Pages 1284-1293

  Daley, Denise ^a   Park, Julie E ^a   He, Jian Qing ^a   Yan, Jin ^a   Akhabir, Loubna ^a   Stefanowicz, Dorota ^a   Becker, Allan B ^b   Chan Yeung, Moira ^a   Bossé, Yohan ^c,d   Kozyrskyj, Anita L ^e,f   James, Alan L ^g   Musk, Arthur W ^g   Laprise, Catherine ^h,i   Hegele, Richard G ^j   Paré, Peter D ^a   Sandford, Andrew J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c LAVAL UNIVERSITY   (Canada)

^d UNIVERSITÉ LAVAL   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

^f UNIVERSITY OF MANITOBA   (Canada)

^g SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^h UNIVERSITÉ DU QUÉBEC À CHICOUTIMI   (Canada)

ⁱ UNIVERSITÉ DE MONTRÉAL   (Canada)

^j UNIVERSITY OF TORONTO   (Canada)

more..

Author keywords

airway hyperresponsiveness; association; Asthma; atopic asthma; atopy; gene environment interactions; genetics; viral exposures

Indexed keywords

INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 18 RECEPTOR; MEMBRANE PROTEIN; PROTEIN NFKBIA; PROTEIN NFKBIB; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; ATOPY; AUSTRALIA; BIRTH; CANADA; CHILD; CLINICAL ASSESSMENT TOOL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; FAMILY; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; HIGH RISK PATIENT; HUMAN; INFANT; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; PARAINFLUENZA VIRUS; PHENOTYPE; PICORNAVIRUS; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT ALLERGY; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSMISSION DISEQUILIBRIUM TEST; VIRUS CELL INTERACTION; VIRUS INFECTION;

ASTHMA; AUSTRALIA; CANADA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNITY, INNATE; INFANT; INFANT, NEWBORN; MALE; POLYMORPHISM, GENETIC; RECEPTORS, INTERLEUKIN-1; TOLL-LIKE RECEPTOR 1; VIRUS DISEASES;

EID: 84870292367     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.07.051     Document Type: Article

References (54)

1. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC Lancet 351 1998 1225 1232
2. P.J. Gergen, and K.B. Weiss The increasing problem of asthma in the United States Am Rev Respir Dis 146 1992 823 824
3. C. Anandan, U. Nurmatov, O.C. van Schayck, and A. Sheikh Is the prevalence of asthma declining? Systematic review of epidemiological studies Allergy 65 2010 152 167
4. D.P. Strachan Hay fever, hygiene, and household size BMJ 299 1989 1259 1260
5. A. Dunne, and L.A. O'Neill The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense Sci STKE 2003 2003 re3
6. S. Phipps, C.E. Lam, P.S. Foster, and K.I. Matthaei The contribution of toll-like receptors to the pathogenesis of asthma Immunol Cell Biol 85 2007 463 470
7. K. Gupta, and A. Bewtra IL-1 receptor-type expression in relation to atopy J Allergy Clin Immunol 103 1999 1100 1107
8. M. Watanabe, H. Kaneko, H. Shikano, M. Aoki, H. Sakaguchi, and E. Matsui Predominant expression of 950delCAG of IL-18R alpha chain cDNA is associated with reduced IFN-gamma production and high serum IgE levels in atopic Japanese children J Allergy Clin Immunol 109 2002 669 675
9. K. Kuribayashi, T. Kodama, H. Okamura, M. Sugita, and T. Matsuyama Effects of post-inhalation treatment with interleukin-12 on airway hyper-reactivity, eosinophilia and interleukin-18 receptor expression in a mouse model of asthma Clin Exp Allergy 32 2002 641 649
10. P. Ahmad-Nejad, S. Mrabet-Dahbi, K. Breuer, M. Klotz, T. Werfel, and U. Herz The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype J Allergy Clin Immunol 113 2004 565 567
11. E. Noguchi, F. Nishimura, H. Fukai, J. Kim, K. Ichikawa, and M. Shibasaki An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population Clin Exp Allergy 34 2004 177 183
12. K. Tantisira, W.T. Klimecki, R. Lazarus, L.J. Palmer, B.A. Raby, and D.J. Kwiatkowski Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma Genes Immun 5 2004 343 346
13. R. Lazarus, W.T. Klimecki, B.A. Raby, D. Vercelli, L.J. Palmer, and D.J. Kwiatkowski Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies Genomics 81 2003 85 91
14. H. Lyon, C. Lange, S. Lake, E.K. Silverman, A.G. Randolph, and D. Kwiatkowski IL10 gene polymorphisms are associated with asthma phenotypes in children Genet Epidemiol 26 2004 155 165
15. P.N. Le Souef Gene-environmental interaction in the development of atopic asthma: new developments Curr Opin Allergy Clin Immunol 9 2009 123 127
16. P.D. Sly The early origins of asthma: who is really at risk? Curr Opin Allergy Clin Immunol 11 2011 24 28
17. F.D. Martinez The origins of asthma and chronic obstructive pulmonary disease in early life Proc Am Thorac Soc 6 2009 272 277
18. T.M. Ball, J.A. Castro-Rodriguez, K.A. Griffith, C.J. Holberg, F.D. Martinez, and A.L. Wright Siblings, day-care attendance, and the risk of asthma and wheezing during childhood N Engl J Med 343 2000 538 543
19. K.K. Lee, R.G. Hegele, J. Manfreda, K. Wooldrage, A.B. Becker, and A.C. Ferguson Relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: the Canadian Asthma Primary Prevention Study Pediatr Pulmonol 42 2007 290 297
20. J.E. Gern The ABCs of rhinoviruses, wheezing, and asthma J Virol 84 2010 7418 7426
21. S.D. Message, and S.L. Johnston The immunology of virus infection in asthma Eur Respir J 18 2001 1013 1025
22. E.K. Miller, J.V. Williams, T. Gebretsadik, K.N. Carroll, W.D. Dupont, and Y.A. Mohamed Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness J Allergy Clin Immunol 127 2011 883 891
23. S. Guerra, and F.D. Martinez Asthma genetics: from linear to multifactorial approaches Annu Rev Med 59 2008 327 341
24. D. Daley, M. Lemire, L. Akhabir, M. Chan-Yeung, J.Q. He, and T. McDonald Analyses of associations with asthma in four asthma population samples from Canada and Australia Hum Genet 125 2009 445 459
25. M. Chan-Yeung, J. Manfreda, H. Dimich-Ward, A. Ferguson, W. Watson, and A. Becker A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants Arch Pediatr Adolesc Med 154 2000 657 663
26. M. Chan-Yeung, A. Ferguson, W. Watson, H. Dimich-Ward, R. Rousseau, and M. Lilley The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age J Allergy Clin Immunol 116 2005 49 55
27. L.L. Gilbert, A. Dakhama, B.M. Bone, E.E. Thomas, and R.G. Hegele Diagnosis of viral respiratory tract infections in children by using a reverse transcription-PCR panel J Clin Microbiol 34 1996 140 143
28. R.G. Hegele, H.Y. Ahmad, A.B. Becker, H. Dimich-Ward, A.C. Ferguson, and J. Manfreda The association between respiratory viruses and symptoms in 2-week-old infants at high risk for asthma and allergy J Pediatr 138 2001 831 837
29. A.L. Kozyrskyj, X.M. Mai, P. McGrath, K.T. Hayglass, A.B. Becker, and B. Macneil Continued exposure to maternal distress in early life is associated with an increased risk of childhood asthma Am J Respir Crit Care Med 177 2008 142 147
30. X.M. Mai, A.B. Becker, E.A. Sellers, J.J. Liem, and A.L. Kozyrskyj The relationship of breast-feeding, overweight, and asthma in preadolescents J Allergy Clin Immunol 120 2007 551 556
31. A.L. Kozyrskyj, K.T. HayGlass, A.J. Sandford, P.D. Pare, M. Chan-Yeung, and A.B. Becker A novel study design to investigate the early-life origins of asthma in children (SAGE study) Allergy 64 2009 1185 1193
32. P. Begin, K. Tremblay, D. Daley, M. Lemire, S. Claveau, and C. Salesse Association of urokinase-type plasminogen activator with asthma and atopy Am J Respir Crit Care Med 175 2007 1109 1116
33. A.H. Poon, C. Laprise, M. Lemire, A. Montpetit, D. Sinnett, and E. Schurr Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy Am J Respir Crit Care Med 170 2004 967 973
34. B.A. Raby, R. Lazarus, E.K. Silverman, S. Lake, C. Lange, and M. Wjst Association of vitamin D receptor gene polymorphisms with childhood and adult asthma Am J Respir Crit Care Med 170 2004 1057 1065
35. A.L. James, M.W. Knuiman, H.C. Bartholomew, and A.B. Musk What can Busselton population health surveys tell us about asthma in older people? Med J Aust 183 suppl 2005 S17 S19
36. A.L. James, L.J. Palmer, E. Kicic, P.S. Maxwell, S.E. Lagan, and G.F. Ryan Decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking Am J Respir Crit Care Med 171 2005 109 114
37. S. Godfrey Bronchial hyper-responsiveness in children Paediatr Respir Rev 1 2000 148 155
38. S. Godfrey, C. Springer, E. Bar-Yishay, and A. Avital Cut-off points defining normal and asthmatic bronchial reactivity to exercise and inhalation challenges in children and young adults Eur Respir J 14 1999 659 668
39. C.S. Carlson, M.A. Eberle, M.J. Rieder, Q. Yi, L. Kruglyak, and D.A. Nickerson Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium Am J Hum Genet 74 2004 106 120
40. F. Dudbridge Pedigree disequilibrium tests for multilocus haplotypes Genet Epidemiol 25 2003 115 121
41. F. Dudbridge Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data Hum Hered 66 2008 87 98
42. R.S. Spielman, and W.J. Ewens The TDT and other family-based tests for linkage disequilibrium and association Am J Hum Genet 59 1996 983 989
43. J.Q. He, T.S. Hallstrand, D. Knight, M. Chan-Yeung, A. Sandford, and B. Tripp A thymic stromal lymphopoietin gene variant is associated with asthma and airway hyperresponsiveness J Allergy Clin Immunol 124 2009 222 229
44. H.J. Cordell Estimation and testing of gene-environment interactions in family-based association studies Genomics 93 2009 5 9
45. F. Colotta, F. Re, M. Muzio, R. Bertini, N. Polentarutti, and M. Sironi Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4 Science 261 1993 472 475
46. T. Sekigawa, A. Tajima, T. Hasegawa, Y. Hasegawa, H. Inoue, and Y. Sano Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma Clin Exp Allergy 39 2009 972 981
47. O. Takeuchi, S. Sato, T. Horiuchi, K. Hoshino, K. Takeda, and Z. Dong Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins J Immunol 169 2002 10 14
48. Y. Guan, D.R. Ranoa, S. Jiang, S.K. Mutha, X. Li, and J. Baudry Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling J Immunol 184 2010 5094 5103
49. M.S. Kormann, M. Depner, D. Hartl, N. Klopp, T. Illig, and J. Adamski Toll-like receptor heterodimer variants protect from childhood asthma J Allergy Clin Immunol 122 2008 86 92 e1-8
50. R.R. Schumann, S.R. Leong, G.W. Flaggs, P.W. Gray, S.D. Wright, and J.C. Mathison Structure and function of lipopolysaccharide binding protein Science 249 1990 1429 1431
51. S.D. Wright, R.A. Ramos, P.S. Tobias, R.J. Ulevitch, and J.C. Mathison CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein Science 249 1990 1431 1433
52. H. Gazzano-Santoro, J.B. Parent, L. Grinna, A. Horwitz, T. Parsons, and G. Theofan High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide Infect Immun 60 1992 4754 4761
53. N.E. Reijmerink, D.S. Postma, M. Bruinenberg, I.M. Nolte, D.A. Meyers, and E.R. Bleecker Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy J Allergy Clin Immunol 122 2008 651 654 e8
54. M.F. Moffatt, I.G. Gut, F. Demenais, D.P. Strachan, E. Bouzigon, and S. Heath A large-scale, consortium-based genomewide association study of asthma N Engl J Med 363 2010 1211 1221