메뉴 건너뛰기




Volumn 96, Issue 5, 2011, Pages 729-737

Polymorphisms of nuclear factor-κB family genes are associated with development of multiple myeloma and treatment outcome in patients receiving bortezomib-based regimens

Author keywords

Multiple myeloma; NF B; SNP

Indexed keywords

BORTEZOMIB; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; THALIDOMIDE;

EID: 79955738089     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.030577     Document Type: Article
Times cited : (44)

References (45)
  • 1
    • 6944235003 scopus 로고    scopus 로고
    • Multiple myeloma
    • Kyle RA, Rajkumar SV. Multiple myeloma. N Engl J Med. 2004;351(18):1860-1873.
    • (2004) N Engl J Med , vol.351 , Issue.18 , pp. 1860-1873
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 2
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 2009;8(1):33-40.
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.1 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 3
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factorkappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
    • Basseres DS, Baldwin AS. Nuclear factorkappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene. 2006;25(51):6817-6830.
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6817-6830
    • Basseres, D.S.1    Baldwin, A.S.2
  • 4
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-kappaB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications
    • Jost PJ, Ruland J. Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood. 2007;109(7):2700-2707.
    • (2007) Blood , vol.109 , Issue.7 , pp. 2700-2707
    • Jost, P.J.1    Ruland, J.2
  • 5
    • 36348988506 scopus 로고    scopus 로고
    • Nuclear factor κB as a target for new drug development in myeloid malignancies
    • Cilloni D, Martinelli G, Messa F, Baccarani M, Saglio G. Nuclear factor κB as a target for new drug development in myeloid malignancies. Haematologica. 2007;92(9): 1224-1229.
    • (2007) Haematologica , vol.92 , Issue.9 , pp. 1224-1229
    • Cilloni, D.1    Martinelli, G.2    Messa, F.3    Baccarani, M.4    Saglio, G.5
  • 6
    • 33750475618 scopus 로고    scopus 로고
    • Current insights into the regulation of programmed cell death by NF-kappaB
    • Dutta J, Fan Y, Gupta N, Fan G, Gelinas C. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene. 2006;25(51):6800-6816.
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6800-6816
    • Dutta, J.1    Fan, Y.2    Gupta, N.3    Fan, G.4    Gelinas, C.5
  • 7
    • 29444453188 scopus 로고    scopus 로고
    • The anti-death machinery in IKK/NF-kappaB signaling
    • Luo JL, Kamata H, Karin M. The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol. 2005;25(6):541-550.
    • (2005) J Clin Immunol , vol.25 , Issue.6 , pp. 541-550
    • Luo, J.L.1    Kamata, H.2    Karin, M.3
  • 8
    • 0344845002 scopus 로고    scopus 로고
    • Dying for NFkappaB? Control of cell death by transcriptional regulation of the apoptotic machinery
    • Burstein E, Duckett CS. Dying for NFkappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol. 2003;15(6):732-737.
    • (2003) Curr Opin Cell Biol , vol.15 , Issue.6 , pp. 732-737
    • Burstein, E.1    Duckett, C.S.2
  • 9
    • 64849085443 scopus 로고    scopus 로고
    • Proteasome inhibitors in multiple myeloma
    • Anderson KC. Proteasome inhibitors in multiple myeloma. Semin Oncol. 2009;36(2 Suppl 1):S20-S26.
    • (2009) Semin Oncol , vol.36 , Issue.1-2 SUPPL.
    • Anderson, K.C.1
  • 10
    • 27144477320 scopus 로고    scopus 로고
    • N-(4-hydroxyphenyl) retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factorkappaB- regulated gene products
    • Shishodia S, Gutierrez AM, Lotan R, Aggarwal BB. N-(4-hydroxyphenyl) retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factorkappaB- regulated gene products. Cancer Res. 2005;65(20):9555-9565.
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9555-9565
    • Shishodia, S.1    Gutierrez, A.M.2    Lotan, R.3    Aggarwal, B.B.4
  • 11
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
    • Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007;12(2):115-130.
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 115-130
    • Annunziata, C.M.1    Davis, R.E.2    Demchenko, Y.3    Bellamy, W.4    Gabrea, A.5    Zhan, F.6
  • 12
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NFkappaB pathway in multiple myeloma
    • Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ, et al. Promiscuous mutations activate the noncanonical NFkappaB pathway in multiple myeloma. Cancer Cell. 2007;12(2):131-144.
    • (2007) Cancer Cell , vol.12 , Issue.2 , pp. 131-144
    • Keats, J.J.1    Fonseca, R.2    Chesi, M.3    Schop, R.4    Baker, A.5    Chng, W.J.6
  • 13
    • 0035896422 scopus 로고    scopus 로고
    • Defective lymphotoxin- beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
    • Yin L, Wu L, Wesche H, Arthur CD, White JM, Goeddel DV, et al. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science. 2001;291(5511):2162-5.
    • (2001) Science , vol.291 , Issue.5511 , pp. 2162-2165
    • Yin, L.1    Wu, L.2    Wesche, H.3    Arthur, C.D.4    White, J.M.5    Goeddel, D.V.6
  • 14
    • 38849140346 scopus 로고    scopus 로고
    • A novel mutation in the Nfkb2 gene generates an NF-kappa B2 super repressor
    • Tucker E, O'Donnell K, Fuchsberger M, Hilton AA, Metcalf D, Greig K, et al. A novel mutation in the Nfkb2 gene generates an NF-kappa B2 super repressor. J Immunol. 2007;179(11):7514-7522.
    • (2007) J Immunol , vol.179 , Issue.11 , pp. 7514-7522
    • Tucker, E.1    O'Donnell, K.2    Fuchsberger, M.3    Hilton, A.A.4    Metcalf, D.5    Greig, K.6
  • 15
    • 14544286868 scopus 로고    scopus 로고
    • TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5 mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs
    • Hauer J, Puschner S, Ramakrishnan P, Simon U, Bongers M, Federle C, et al. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5 mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci USA. 2005;102(8):2874-289.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.8 , pp. 2874-2879
    • Hauer, J.1    Puschner, S.2    Ramakrishnan, P.3    Simon, U.4    Bongers, M.5    Federle, C.6
  • 16
    • 2942731516 scopus 로고    scopus 로고
    • Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptorassociated factor 3-induced degradation
    • Liao G, Zhang M, Harhaj EW, Sun SC. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptorassociated factor 3-induced degradation. J Biol Chem. 2004;279(25):26243-26250.
    • (2004) J Biol Chem , vol.279 , Issue.25 , pp. 26243-26250
    • Liao, G.1    Zhang, M.2    Harhaj, E.W.3    Sun, S.C.4
  • 17
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • Nakanishi C, Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer. 2005;5(4):297-309.
    • (2005) Nat Rev Cancer , vol.5 , Issue.4 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 21
    • 41549133200 scopus 로고    scopus 로고
    • Proteasome inhibitors in cancer therapy: Lessons from the first decade
    • Orlowski RZ, Kuhn DJ. Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res. 2008; 14(6):1649-1657.
    • (2008) Clin Cancer Res , vol.14 , Issue.6 , pp. 1649-1657
    • Orlowski, R.Z.1    Kuhn, D.J.2
  • 22
    • 39749085426 scopus 로고    scopus 로고
    • Sustained complete remissions in multiple myeloma linked to bortezomib in total therapy 3: Comparison with total therapy 2
    • Pineda-Roman M, Zangari M, Haessler J, Anaissie E, Tricot G, van RF, et al. Sustained complete remissions in multiple myeloma linked to bortezomib in total therapy 3: comparison with total therapy 2. Br J Haematol. 2008;140(6):625-634.
    • (2008) Br J Haematol , vol.140 , Issue.6 , pp. 625-634
    • Pineda-Roman, M.1    Zangari, M.2    Haessler, J.3    Anaissie, E.4    Tricot, G.5    Van, R.F.6
  • 23
    • 64749097025 scopus 로고    scopus 로고
    • Front-line treatment in younger patients with multiple myeloma
    • Rajkumar SV, Sonneveld P. Front-line treatment in younger patients with multiple myeloma. Semin Hematol. 2009;46(2):118-126.
    • (2009) Semin Hematol , vol.46 , Issue.2 , pp. 118-126
    • Rajkumar, S.V.1    Sonneveld, P.2
  • 24
    • 18644365198 scopus 로고    scopus 로고
    • Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma
    • Parker KM, Ma MH, Manyak S, Altamirano CV, Tang YM, Frantzen M, et al. Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. Cancer Genet Cytogenet. 2002;137(1):43-48.
    • (2002) Cancer Genet Cytogenet , vol.137 , Issue.1 , pp. 43-48
    • Parker, K.M.1    Ma, M.H.2    Manyak, S.3    Altamirano, C.V.4    Tang, Y.M.5    Frantzen, M.6
  • 25
    • 33845657849 scopus 로고    scopus 로고
    • Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma
    • Spink CF, Gray LC, Davies FE, Morgan GJ, Bidwell JL. Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma. Cancer Lett. 2007;246(1-2):92-99.
    • (2007) Cancer Lett , vol.246 , Issue.1-2 , pp. 92-99
    • Spink, C.F.1    Gray, L.C.2    Davies, F.E.3    Morgan, G.J.4    Bidwell, J.L.5
  • 26
    • 1242307897 scopus 로고    scopus 로고
    • A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene
    • Klein W, Tromm A, Folwaczny C, Hagedorn M, Duerig N, Epplen JT, et al. A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene. Int J Colorectal Dis. 2004;19(2):153-156.
    • (2004) Int J Colorectal Dis , vol.19 , Issue.2 , pp. 153-156
    • Klein, W.1    Tromm, A.2    Folwaczny, C.3    Hagedorn, M.4    Duerig, N.5    Epplen, J.T.6
  • 27
    • 0035348059 scopus 로고    scopus 로고
    • Polymorphisms in the IkappaB-alpha promoter region and risk of diseases involving inflammation and fibrosis
    • Mozzato-Chamay N, Corbett EL, Bailey RL, Mabey DC, Raynes J, Conway DJ. Polymorphisms in the IkappaB-alpha promoter region and risk of diseases involving inflammation and fibrosis. Genes Immun. 2001;2(3):153-155.
    • (2001) Genes Immun , vol.2 , Issue.3 , pp. 153-155
    • Mozzato-Chamay, N.1    Corbett, E.L.2    Bailey, R.L.3    Mabey, D.C.4    Raynes, J.5    Conway, D.J.6
  • 28
    • 2142771661 scopus 로고    scopus 로고
    • Inhibitor kappa B-alpha (IkappaBalpha) promoter polymorphisms in UK and Dutch sarcoidosis
    • Abdallah A, Sato H, Grutters JC, Veeraraghavan S, Lympany PA, Ruven HJ, et al. Inhibitor kappa B-alpha (IkappaBalpha) promoter polymorphisms in UK and Dutch sarcoidosis. Genes Immun. 2003;4(6):450-454.
    • (2003) Genes Immun , vol.4 , Issue.6 , pp. 450-454
    • Abdallah, A.1    Sato, H.2    Grutters, J.C.3    Veeraraghavan, S.4    Lympany, P.A.5    Ruven, H.J.6
  • 30
    • 0016804136 scopus 로고
    • A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival
    • Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975;36(3):842-854.
    • (1975) Cancer , vol.36 , Issue.3 , pp. 842-854
    • Durie, B.G.1    Salmon, S.E.2
  • 31
    • 18244428600 scopus 로고    scopus 로고
    • Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant
    • Blade J, Samson D, Reece D, Apperley J, Bjorkstrand B, Gahrton G, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998;102(5): 1115-1123.
    • (1998) Br J Haematol , vol.102 , Issue.5 , pp. 1115-1123
    • Blade, J.1    Samson, D.2    Reece, D.3    Apperley, J.4    Bjorkstrand, B.5    Gahrton, G.6
  • 33
    • 18944381751 scopus 로고    scopus 로고
    • SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
    • Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005;15(2):97-8.
    • (2005) Cell Res , vol.15 , Issue.2 , pp. 97-98
    • Shi, Y.Y.1    He, L.2
  • 34
    • 64149129845 scopus 로고    scopus 로고
    • A partition-ligation-combinationsubdivision EM algorithm for haplotype inference with multiallelic markers: Update of the SHEsis
    • Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z, et al. A partition-ligation-combinationsubdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Res. 2009;19(4):519-523.
    • (2009) Cell Res , vol.19 , Issue.4 , pp. 519-523
    • Li, Z.1    Zhang, Z.2    He, Z.3    Tang, W.4    Li, T.5    Zeng, Z.6
  • 35
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81(3):559-75.
    • (2007) Am J Hum Genet , vol.81 , Issue.3 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5    Bender, D.6
  • 36
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001;68(4):978-89.
    • (2001) Am J Hum Genet , vol.68 , Issue.4 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 37
    • 0242691208 scopus 로고    scopus 로고
    • A comparison of bayesian methods for haplotype reconstruction from population genotype data
    • Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet. 2003;73(5):1162-9.
    • (2003) Am J Hum Genet , vol.73 , Issue.5 , pp. 1162-1169
    • Stephens, M.1    Donnelly, P.2
  • 38
    • 33744475085 scopus 로고    scopus 로고
    • A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter
    • De Gobbi M, Viprakasit V, Hughes JR, Fisher C, Buckle VJ, Ayyub H, et al. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. Science. 2006;312(5777):1215-7.
    • (2006) Science , vol.312 , Issue.5777 , pp. 1215-1217
    • de Gobbi, M.1    Viprakasit, V.2    Hughes, J.R.3    Fisher, C.4    Buckle, V.J.5    Ayyub, H.6
  • 39
    • 0942276839 scopus 로고    scopus 로고
    • The intronic prothrombin 19911A>G polymorphism influences splicing efficiency and modulates effects of the 20210G>A polymorphism on mRNA amount and expression in a stable reporter gene assay system
    • von AN, Oellerich M. The intronic prothrombin 19911A>G polymorphism influences splicing efficiency and modulates effects of the 20210G>A polymorphism on mRNA amount and expression in a stable reporter gene assay system. Blood. 2004;103(2):586-593.
    • (2004) Blood , vol.103 , Issue.2 , pp. 586-593
    • Von, A.N.1    Oellerich, M.2
  • 40
    • 34248648455 scopus 로고    scopus 로고
    • Intronic microRNA: Discovery and biological implications
    • Li SC, Tang P, Lin WC. Intronic microRNA: discovery and biological implications. DNA Cell Biol. 2007;26(4):195-207.
    • (2007) DNA Cell Biol , vol.26 , Issue.4 , pp. 195-207
    • Li, S.C.1    Tang, P.2    Lin, W.C.3
  • 41
    • 70349243697 scopus 로고    scopus 로고
    • Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells
    • Hideshima T, Ikeda H, Chauhan D, Okawa Y, Raje N, Podar K, et al. Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells. Blood. 2009;114(5):1046-1052.
    • (2009) Blood , vol.114 , Issue.5 , pp. 1046-1052
    • Hideshima, T.1    Ikeda, H.2    Chauhan, D.3    Okawa, Y.4    Raje, N.5    Podar, K.6
  • 43
    • 77249167366 scopus 로고    scopus 로고
    • A prospective, multicenter, randomized, trial of bortezomib/melphalan/prednisone (VMP) versus bortezomib/thalidomide/ prednisone (VTP) as induction therapy followed by maintenance treatment with bortezomib/thalidomide (VT) versus bortezomib/ prednisone (VP) in elderly untreated patients with multiple myeloma older than 65 years
    • (ASH Annual Meeting Abstracts)., Abstract 3
    • Mateos MV, Oriol A, Martinez J, Cibeira MT, Gutiérrez NC, Terol MJ, et al. A prospective, multicenter, randomized, trial of bortezomib/melphalan/prednisone (VMP) versus bortezomib/thalidomide/ prednisone (VTP) as induction therapy followed by maintenance treatment with bortezomib/thalidomide (VT) versus bortezomib/ prednisone (VP) in elderly untreated patients with multiple myeloma older than 65 years. Blood (ASH Annual Meeting Abstracts). 2009;114(22):Abstract 3.
    • (2009) Blood , vol.114 , Issue.22
    • Mateos, M.V.1    Oriol, A.2    Martinez, J.3    Cibeira, M.T.4    Gutiérrez, N.C.5    Terol, M.J.6
  • 44
    • 79953083067 scopus 로고    scopus 로고
    • Sequencing novel agents in relapsed/refractory multiple myeloma: Use of bortezomib-based therapy after lenalidomide + dexamethasone
    • Abstract 1853
    • Reece DE, Trieu Y, Chen C, Kukreti V, Xu W, Anglin P, et al. Sequencing Novel Agents in relapsed/refractory multiple myeloma: use of bortezomib-based therapy after lenalidomide + dexamethasone. Blood (ASH Annual Meeting Abstracts). 2009;114 (22):Abstract 1853.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , Issue.22
    • Reece, D.E.1    Trieu, Y.2    Chen, C.3    Kukreti, V.4    Xu, W.5    Anglin, P.6
  • 45
    • 33847369790 scopus 로고    scopus 로고
    • Treatment of newly diagnosed multiple myeloma based on Mayo Stratification of Myeloma and Risk-adapted Therapy (mSMART): Consensus statement
    • Dispenzieri A, Rajkumar SV, Gertz MA, Fonseca R, Lacy MQ, Bergsagel PL, et al. Treatment of newly diagnosed multiple myeloma based on Mayo Stratification of Myeloma and Risk-adapted Therapy (mSMART): consensus statement. Mayo Clin Proc. 2007;82(3):323-341.
    • (2007) Mayo Clin Proc , vol.82 , Issue.3 , pp. 323-341
    • Dispenzieri, A.1    Rajkumar, S.V.2    Gertz, M.A.3    Fonseca, R.4    Lacy, M.Q.5    Bergsagel, P.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.