Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct

New England Journal of Medicine

Volumn 378, Issue 1, 2018, Pages 11-21

  Nogueira, R G ^a   Jadhav, A P ^b   Haussen, D C ^a   Bonafe, A ^e   Budzik, R F ^g   Bhuva, P ⁱ   Yavagal, D R ^l   Ribo, M ^p   Cognard, C ^f   Hanel, R A ^m   Sila, C A ^h   Hassan, A E ^j   Millan, M ^r   Levy, E I ^s   Mitchell, P ^t   Chen, M ^u   English, J D ^v   Shah, Q A ^d   Silver, F L ^ac   Pereira, V M ^ac   Mehta, B P ⁿ   Baxter, B W ^ad   Abraham, M G ^ae   Cardona, P ^q   Veznedaroglu, E ^af   Hellinger, F R ^o   Feng, L ^x   Kirmani, J F ^ag   Lopes, D K ^u   Jankowitz, B T ^c   Frankel, M R ^a   Costalat, V ^e   Vora, N A ^g   Yoo, A J ⁱ   Malik, A M ^l   Furlan, A J ^h   Rubiera, M ^p   Aghaebrahim, A ^m   Olivot, J M ^f   Tekle, W G ^j   Shields, R ^aa   Graves, T ^k   Lewis, R J ^k,ab   Smith, W S ^w   Liebeskind, D S ^y,z   Saver, J L ^z   Jovin, T G ^b   more..

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^c Neurosurgery   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e GUI DE CHAULIAC HOSPITAL   (France)

^f TOULOUSE UNIVERSITY HOSPITAL   (France)

^g RIVERSIDE METHODIST HOSPITAL   (United States)

^h UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

ⁱ Texas Stroke Institute   (United States)

^j Valley Baptist Medical Center   (United States)

^k BERRY CONSULTANTS   (United States)

^l JACKSON MEMORIAL HOSPITAL   (United States)

^m Division of Endocrinology   (United States)

ⁿ MEMORIAL REGIONAL HOSPITAL   (United States)

^o FLORIDA HOSPITAL   (United States)

^p HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^q HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^r UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^s UNIVERSITY AT BUFFALO   (United States)

^t Royal Melbourne Hospital   (United States)

^u RUSH UNIVERSITY MEDICAL CENTER   (United States)

^v CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^w UNIVERSITY OF CALIFORNIA   (United States)

^x KAISER PERMANENTE   (United States)

^y Stroke Center   (United States)

^z UNIVERSITY OF CALIFORNIA   (United States)

^aa Stryker Orthopaedics   (United States)

^ab HARBOR UCLA MEDICAL CENTER   (United States)

^ac TORONTO WESTERN HOSPITAL   (Canada)

^ad UNIVERSITY OF TENNESSEE AT CHATTANOOGA   (United States)

^ae UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^af Capital Health   (United States)

^ag NEW JERSEY NEUROSCIENCE INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; CEREBROVASCULAR ACCIDENT; CLINICAL DEFICIT; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; INTERNAL CAROTID ARTERY OCCLUSION; MAJOR CLINICAL STUDY; MALE; MEDICAL CARE; MULTICENTER STUDY; OCCLUSIVE CEREBROVASCULAR DISEASE; PATIENT SAFETY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RANKIN SCALE; SYMPTOMATOLOGY; THROMBECTOMY; TIME TO TREATMENT; TREATMENT OUTCOME; BAYES THEOREM; CLINICAL TRIAL; COMPLICATION; DIAGNOSTIC IMAGING; DISABILITY; ENDOVASCULAR SURGERY; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; PROCEDURES; VERY ELDERLY;

FIBRINOLYTIC AGENT;

AGED; AGED, 80 AND OVER; BAYES THEOREM; CEREBRAL INFARCTION; COMBINED MODALITY THERAPY; DISABILITY EVALUATION; ENDOVASCULAR PROCEDURES; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INTRACRANIAL HEMORRHAGES; MALE; MIDDLE AGED; STROKE; THROMBECTOMY; TIME-TO-TREATMENT;

EID: 85040348659     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1706442     Document Type: Article

References (26)

1. Berkhemer OA, Fransen PSS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015;372:11-20.
2. Campbell BCV, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 2015;372:1009-18.
3. Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 2015;372:1019-30.
4. Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med 2015;372:2296-306.
5. Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 2015;372:2285-95.
6. Bracard S, Ducrocq X, Mas JL, et al. Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial. Lancet Neurol 2016;15:1138-47.
7. Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a metaanalysis of individual patient data from five randomised trials. Lancet 2016;387:1723-31.
8. Saver JL, Goyal M, van der Lugt A, et al. Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA 2016;316:1279-88.
9. Dávalos A, Blanco M, Pedraza S, et al. The clinical-DWI mismatch: a new diagnostic approach to the brain tissue at risk of infarction. Neurology 2004;62:2187-92.
10. Jovin TG, Liebeskind DS, Gupta R, et al. Imaging-based endovascular therapy for acute ischemic stroke due to proximal intracranial anterior circulation occlusion treated beyond 8 hours from time last seen well: retrospective multicenter analysis of 237 consecutive patients. Stroke 2011;42:2206-11.
11. Lansberg MG, Cereda CW, Mlynash M, et al. Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue. Neurology 2015;85:708-14.
12. Jovin TG, Saver JL, Ribo M, et al. Diffusionweighted imaging or computerized tomography perfusion assessment with clinical mismatch in the triage of wake up and late presenting strokes undergoing neurointervention with Trevo (DAWN) trial methods. Int J Stroke 2017;12:641-52.
13. Stryker. Welcome to the DAWN trial campus (http://dawntrial.trainingcampus.net).
14. NETT mRS test. Ann Arbor: University of Michigan (https://lessons.ummu.umich.edu/2k/nett-mrs/test).
15. Patel RD, Starkman S, Hamilton S, et al. The Rankin Focused Assessment-Ambulation: a method to score the Modified Rankin Scale with emphasis on walking ability. J Stroke Cerebrovasc Dis 2016;25:2172-6.
16. Rivero-Arias O, Ouellet M, Gray A, Wolstenholme J, Rothwell PM, Luengo-Fernandez R. Mapping the modified Rankin scale (mRS) measurement into the generic EuroQol (EQ-5D) health outcome. Med Decis Making 2010;30:341-54.
17. Hong KS, Saver JL. Quantifying the value of stroke disability outcomes: WHO Global Burden of Disease Project disability weights for each level of the modified Rankin Scale. Stroke 2009;40:3828-33.
18. Chaisinanunkul N, Adeoye O, Lewis RJ, et al. Adopting a patient-centered approach to primary outcome analysis of acute stroke trials using a utility-weighted modified Rankin scale. Stroke 2015;46:2238-43.
19. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-29.
20. Hernández-Pérez M, Pérez de la Ossa N, Aleu A, et al. Natural history of acute stroke due to occlusion of the middle cerebral artery and intracranial internal carotid artery. J Neuroimaging 2014;24:354-8.
21. Lima FO, Furie KL, Silva GS, et al. Prognosis of untreated strokes due to anterior circulation proximal intracranial arterial occlusions detected by use of computed tomography angiography. JAMA Neurol 2014;71:151-7.
22. Janardhan V, Venizelos A, Gianatasio RM, et al. Natural history of acute stroke from large vessel proximal occlusion: a comparison with the IMS III patients. Stroke 2014;45:Suppl 1: AWMP8.
23. Albers GW, Lansberg MG, Kemp S, et al. A multicenter randomized controlled trial of endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3). Int J Stroke 2017;12:896-905.
24. Mishra NK, Christensen S, Wouters A, et al. Reperfusion of very low cerebral blood volume lesion predicts parenchymal hematoma after endovascular therapy. Stroke 2015;46:1245-9.
25. Copen WA, Rezai Gharai L, Barak ER, et al. Existence of the diffusion-perfusion mismatch within 24 hours after onset of acute stroke: dependence on proximal arterial occlusion. Radiology 2009;250:878-86.
26. Rai AT, Seldon AE, Boo S, et al. A populationbased incidence of acute large vessel occlusions and thrombectomy eligible patients indicates significant potential for growth of endovascular stroke therapy in the USA. J Neurointerv Surg 2017;9:722-6.