Characterisation of peptide interactions that regulate PKCε activation

FEBS Letters

Volumn 592, Issue 2, 2018, Pages 179-189

  Chandrashekaran, Indu R ^a   Norton, Raymond S ^a   Schmitz Peiffer, Carsten ^b,c  

^a MONASH UNIVERSITY   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

C2 domain; peptides; protein kinase C; RACK2; saturation transfer difference NMR; surface plasmon resonance

Indexed keywords

PEPTIDE; PEPTIDE EPSILON V1 2; PEPTIDE PSEUDO EPSILON RECEPTOR FOR ACTIVATED C KINASE; PROTEIN KINASE C EPSILON; RECEPTOR FOR ACTIVATED C KINASE 2; UNCLASSIFIED DRUG; PROTEIN BINDING; RECEPTOR FOR ACTIVATED C KINASE;

ARTICLE; BIOPHYSICS; ENZYME ACTIVATION; ENZYME BINDING; ENZYME INHIBITION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SURFACE PLASMON RESONANCE; ANIMAL; BINDING SITE; CHEMISTRY; DRUG EFFECT; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BINDING SITES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN KINASE C-EPSILON; PROTEIN STRUCTURE, TERTIARY; RECEPTORS FOR ACTIVATED C KINASE; SURFACE PLASMON RESONANCE;

EID: 85040219737     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1002/1873-3468.12953     Document Type: Article

References (37)

1. Reyland ME (2009) Protein kinase C isoforms: multi-functional regulators of cell life and death. Front Biosci 14, 2386–2399.
2. Schmitz-Peiffer C (2013) The tail wagging the dog - regulation of lipid metabolism by protein kinase C. The FEBS journal 280, 5371–5383.
3. Schmitz-Peiffer C and Biden TJ (2008) Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes. Diabetes 57, 1774–1783.
4. Mochly-Rosen D, Das K and Grimes KV (2012) Protein kinase C, an elusive therapeutic target? Nat Rev Drug Discov 11, 937–957.
5. Antal CE and Newton AC (2014) Tuning the signalling output of protein kinase C. Biochem Soc Trans 42, 1477–1483.
6. Budas GR, Koyanagi T, Churchill EN and Mochly-Rosen D (2007) Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic. Biochem Soc Trans 35, 1021–1026.
7. Rechfeld F, Gruber P, Kirchmair J, Boehler M, Hauser N, Hechenberger G, Garczarczyk D, Lapa GB, Preobrazhenskaya MN, Goekjian P et al. (2014) Thienoquinolines as novel disruptors of the PKCepsilon/RACK2 protein-protein interaction. J Med Chem 57, 3235–3246.
8. Parker PJ and Murray-Rust J (2004) PKC at a glance. J Cell Sci 117, 131–132.
9. Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC and Newton AC (2016) Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation. Biochem J 473, 509–523.
10. Esseltine JL and Scott JD (2013) AKAP signaling complexes: pointing towards the next generation of therapeutic targets? Trends Pharmacol Sci 34, 648–655.
11. Schechtman D and Mochly-Rosen D (2001) Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20, 6339–6347.
12. Csukai M, Chen CH, Dematteis MA and Mochly-Rosen D (1997) The coatomer protein beta’-cop, a selective binding protein (RACK) for PKCε. J Biol Chem 272, 29200–29206.
13. Waters MG, Serafini T and Rothman JE (1991) ‘Coatomer’: a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles. Nature 349, 248–251.
14. Serafini T, Orci L, Amherdt M, Brunner M, Kahn RA and Rothman JE (1991) ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein. Cell 67, 239–253.
15. Johnson JA, Gray MO, Chen CH and Mochly-Rosen D (1996) A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. J Biol Chem 271, 24962–24966.
16. Yedovitzky M, Mochlyrosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E and Nesher R (1997) Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic β-cells. J Biol Chem 272, 1417–1420.
17. Gray MO, Karliner JS and Mochly-Rosen D (1997) A selective epsilon-protein kinase c antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J Biol Chem 272, 30945–30951.
18. Schmitz-Peiffer C, Laybutt DR, Burchfield JG, Gurisik E, Narasimhan S, Mitchell CJ, Pedersen DJ, Braun U, Cooney GJ, Leitges M et al. (2007) Inhibition of PKCε improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab 6, 320–328.
19. House C and Kemp BE (1987) Protein kinase C contains a pseudosubstrate prototype in its regulatory domain. Science 238, 1726–1728.
20. Dorn GW, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN and Mochly-Rosen D (1999) Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proc Nat Acad Sci USA 96, 12798–12803.
21. Souroujon MC and Mochly-Rosen D (1998) Peptide modulators of protein-protein interactions in intracellular signaling. Nat Biotechnol 16, 919–924.
22. 2+-independent C2 domains. J Mol Biol 311, 837–849.
23. Wang QJ, Lu G, Schlapkohl WA, Goerke A, Larsson C, Mischak H, Blumberg PM and Mushinski JF (2004) The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-δ and -ε. Mol Cancer Res 2, 129–140.
24. Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J and Mochly-Rosen D (2004) A critical intramolecular interaction for protein kinase C epsilon translocation. J Biol Chem 279, 15831–15840.
25. Schasfoort RB (2017) Handbook of Surface Plasmon Resonance, The Royal Society of Chemistry
26. Meyer B and Peters T (2003) NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors. Angew Chem Int Ed Engl 42, 864–890.
27. Burchfield JG, Lennard AJ, Narasimhan S, Hughes WE, Wasinger VC, Corthals GL, Okuda T, Kondoh H, Biden TJ and Schmitz-Peiffer C (2004) Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase Cθ. J Biol Chem 279, 18623–18632.
28. Liron T, Chen LE, Khaner H, Vallentin A and Mochly-Rosen D (2007) Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide. J Mol Cell Cardiol 42, 835–841.
29. + channels. Am J Physiol 281, C1477–C1486.
30. Malhotra A, Kang BPS, Hashmi S and Meggs LG (2005) PKC epsilon inhibits the hyperglycemia-induced apoptosis signal in adult rat ventricular myocytes. Mol Cell Biochem 268, 169–173.
31. Brandman R, Disatnik MH, Churchill E and Mochly-Rosen D (2007) Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces. J Biol Chem 282, 4113–4123.
32. Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D and Diamond I (2008) Dopamine and ethanol cause translocation of epsilonPKC associated with εRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways. Mol Pharmacol 73, 1105–1112.
33. Monti M, Donnini S, Morbidelli L, Giachetti A, Mochly-Rosen D, Mignatti P and Ziche M (2013) PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting. J Mol Cell Cardiol 63, 107–117.
34. Farah CA and Sossin WS (2011) A new mechanism of action of a C2 domain-derived novel PKC inhibitor peptide. Neurosci Lett 504, 306–310.
35. Slater SJ, Seiz JL, Cook AC, Buzas CJ, Malinowski SA, Kershner JL, Stagliano BA and Stubbs CD (2002) Regulation of PKCαactivity by C1-C2 domain interactions. J Biol Chem 277, 15277–15285.
36. Newton AC, Antal CE and Steinberg SF (2016) Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond) 130, 1499–1510.
37. Raddatz K, Turner N, Frangioudakis G, Liao BM, Pedersen DJ, Cantley J, Wilks D, Preston E, Hegarty BD, Leitges M et al. (2011) Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice. Diabetologia 54, 1447–1456.