Metformin inhibits development of diabetic retinopathy through microRNA-497A-5p

American Journal of Translational Research

Volumn 9, Issue 12, 2017, Pages 5558-5566

  Zhang, Yi ^a   Chen, Fei ^a   Wang, Liang ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Diabetic retinopathy (DR); MiR 497a 5p; Retina neovascularization; Vascular endothelial cell growth factor A (VEGF A)

Indexed keywords

METFORMIN; MICRORNA; MICRORNA 497A 5P; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ANGIOGRAPHY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; RETINA NEOVASCULARIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 85038936951     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Gunasekaran U and Gannon M. Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) 2011; 3: 565-575.
2. Alusik S and Paluch Z. Metformin: the past, presence, and future. Minerva Med 2015; 106: 233-238.
3. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352: 854-865.
4. Dallaglio K, Bruno A, Cantelmo AR, Esposito AI, Ruggiero L, Orecchioni S, Calleri A, Bertolini F, Pfeffer U, Noonan DM and Albini A. Paradoxic effects of metformin on endothelial cells and angiogenesis. Carcinogenesis 2014; 35: 1055-1066.
5. Li X, Liu X, Guo H, Zhao Z, Li YS and Chen G. The significance of the increased expression of phosphorylated MeCP2 in the membranes from patients with proliferative diabetic retinopathy. Sci Rep 2016; 6: 32850.
6. Wang Y and Yan H. MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy. Sci Rep 2016; 6: 26909.
7. Agrawal R, Smart T, Nobre-Cardoso J, Richards C, Bhatnagar R, Tufail A, Shima D, Jones PH and Pavesio C. Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique. Sci Rep 2016; 6: 15873.
8. Zhang L, Li Y, Payne J, Srivastava S, Fan X, Fung J, Li X, Kern TS and Lin F. Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients. Sci Rep 2016; 6: 20341.
9. Veluthakal R, Kumar B, Mohammad G, Kowluru A and Kowluru RA. Tiam1-Rac1 Axis promotes activation of p38 MAP Kinase in the development of diabetic retinopathy: evidence for a requisite role for protein palmitoylation. Cell Physiol Biochem 2015; 36: 208-220.
10. Chen WP, Wang YD, Ma Y, Zhang ZY, Hu LY, Lin JL and Lin BQ. Danhong Huayu Koufuye combined with metformin attenuated diabetic retinopathy in Zucker diabetic fatty rats. Int J Ophthalmol 2015; 8: 1094-1100.
11. Xiao X, Prasadan K, Guo P, El-Gohary Y, Fischbach S, Wiersch J, Gaffar I, Shiota C and Gittes GK. Pancreatic duct cells as a source of VEGF in mice. Diabetologia 2014; 57: 991-1000.
12. Xiao X, Guo P, Chen Z, El-Gohary Y, Wiersch J, Gaffar I, Prasadan K, Shiota C and Gittes GK. Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic Beta cells as a regulator of Beta cell mass. J Biol Chem 2013; 288: 8636-8646.
13. Villalta SA, Lang J, Kubeck S, Kabre B, Szot GL, Calderon B, Wasserfall C, Atkinson MA, Brekken RA, Pullen N, Arch RH and Bluestone JA. Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes 2013; 62: 2870-2878.
14. Zhou J, Gao Y, Yi X and Ding Y. Ginsenoside Rh2 suppresses neovascularization in xenograft psoriasis model. Cell Physiol Biochem 2015; 36: 980-987.
15. Xu L, Sun K, Xia M, Li X and Lu Y. MMP13 regulates aggressiveness of pediatric multiple myeloma through VEGF-C. Cell Physiol Biochem 2015; 36: 509-516.
16. Jiang H, Wu X, Wang H, Huang C and Zhang L. Combined anti-PLGF and anti-endostatin treatments inhibit ocular hemangiomas. Cell Physiol Biochem 2015; 36: 930-936.
17. Huo X, Li Y, Jiang Y, Sun X, Gu L, Guo W and Sun D. Inhibition of ocular neovascularization by co-inhibition of VEGF-A and PLGF. Cell Physiol Biochem 2015; 35: 1787-1796.
18. Gao Q, Yao X and Zheng J. MiR-323 inhibits prostate cancer vascularization through adiponectin receptor. Cell Physiol Biochem 2015; 36: 1491-1498.
19. Gu A, Lu J, Wang W, Shi C, Han B and Yao M. Role of miR-497 in VEGF-A-mediated cancer cell growth and invasion in non-small cell lung cancer. Int J Biochem Cell Biol 2016; 70: 118-125.
20. Schroeder IS, Rolletschek A, Blyszczuk P, Kania G and Wobus AM. Differentiation of mouse embryonic stem cells to insulin-produc-ing cells. Nat Protoc 2006; 1: 495-507.
21. Higgins RD, Yu K, Sanders RJ, Nandgaonkar BN, Rotschild T and Rifkin DB. Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy. Curr Eye Res 1999; 18: 20-27.
22. Wang J, Li G, Wang Y, Tang S, Sun X, Feng X, Li Y, Bao G, Li P, Mao X, Wang M and Liu P. Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1alpha/VEGF secretion axis. Oncotarget 2015; 6: 44579-44592.
23. Gao S, Jiang J, Li P, Song H, Wang W, Li C and Kong D. Attenuating tumour angiogenesis: a preventive role of metformin against breast cancer. Biomed Res Int 2015; 2015: 592523.
24. Di Pietro M, Parborell F, Irusta G, Pascuali N, Bas D, Bianchi MS, Tesone M and Abramovich D. Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model. Endocrinology 2015; 156: 1453-1463.