메뉴 건너뛰기




Volumn 14, Issue 2, 2018, Pages 286-293

Involvement of TLR3-Dependent PGES Expression in Immunosuppression by Human Bone Marrow Mesenchymal Stem Cells

Author keywords

Cyclooxygenase 2; Immunosuppression; Mesenchymal stem cell; Prostaglandin E synthase; Prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; GAMMA INTERFERON; PROSTAGLANDIN E2; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR; PROSTAGLANDIN E SYNTHASE; TLR3 PROTEIN, HUMAN;

EID: 85038883223     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-017-9793-6     Document Type: Article
Times cited : (20)

References (31)
  • 1
    • 33744913533 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease
    • PID: 16732175
    • Ringden, O., Uzunel, M., Rasmusson, I., Remberger, M., Sundberg, B., Lonnies, H., et al. (2006). Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation, 81(10), 1390–1397.
    • (2006) Transplantation , vol.81 , Issue.10 , pp. 1390-1397
    • Ringden, O.1    Uzunel, M.2    Rasmusson, I.3    Remberger, M.4    Sundberg, B.5    Lonnies, H.6
  • 2
    • 84983287795 scopus 로고    scopus 로고
    • Establishing a tree shrew model of systemic lupus erythematosus and cell transplantation treatment
    • Ruan, G. P., Yao, X., Liu, J. F., He, J., Li, Z. A., Yang, J. Y., et al. (2016). Establishing a tree shrew model of systemic lupus erythematosus and cell transplantation treatment. Stem Cell Research & Therapy, 7(1), 121.
    • (2016) Stem Cell Research & Therapy , vol.7 , Issue.1 , pp. 121
    • Ruan, G.P.1    Yao, X.2    Liu, J.F.3    He, J.4    Li, Z.A.5    Yang, J.Y.6
  • 3
    • 48249144864 scopus 로고    scopus 로고
    • Immunomodulation by mesenchymal stem cells: A potential therapeutic strategy for type 1 diabetes
    • Abdi, R., Fiorina, P., Adra, C., Atkinson, N., M., & Sayegh, M. H. (2008). Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes, 57(7), 1759–1767.
    • (2008) Diabetes , vol.57 , Issue.7 , pp. 1759-1767
    • Abdi, R.1    Fiorina, P.2    Adra, C.3    Atkinson, N.4    Sayegh, M.H.5
  • 5
    • 30144440925 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate B-cell functions
    • COI: 1:CAS:528:DC%2BD28XhsVGksQ%3D%3D, PID: 16141348
    • Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., et al. (2006). Human mesenchymal stem cells modulate B-cell functions. Blood, 107(1), 367–372.
    • (2006) Blood , vol.107 , Issue.1 , pp. 367-372
    • Corcione, A.1    Benvenuto, F.2    Ferretti, E.3    Giunti, D.4    Cappiello, V.5    Cazzanti, F.6
  • 6
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • PID: 11986244
    • Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P. D., Matteucci, P., et al. (2002). Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 99(10), 3838–3843.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6
  • 7
    • 61849123247 scopus 로고    scopus 로고
    • Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25(High) forkhead box P3 + regulatory T cells
    • COI: 1:CAS:528:DC%2BD1MXksVKhsrg%3D
    • English, K., Ryan, J. M., Tobin, L., Murphy, M. J., Barry, F. P., & Mahon, B. P. (2009). Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25(High) forkhead box P3 + regulatory T cells. Clininical and Experimental Immunology, 156(1), 149–160.
    • (2009) Clininical and Experimental Immunology , vol.156 , Issue.1 , pp. 149-160
    • English, K.1    Ryan, J.M.2    Tobin, L.3    Murphy, M.J.4    Barry, F.P.5    Mahon, B.P.6
  • 8
    • 38949183675 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2
    • COI: 1:CAS:528:DC%2BD1cXhvFejtLk%3D, PID: 17951526
    • Spaggiari, G. M., Capobianco, A., Abdelrazik, H., Becchetti, F., Mingari, M. C., & Moretta, L. (2008). Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2. Blood, 111(3), 1327–1333.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1327-1333
    • Spaggiari, G.M.1    Capobianco, A.2    Abdelrazik, H.3    Becchetti, F.4    Mingari, M.C.5    Moretta, L.6
  • 9
    • 69249227552 scopus 로고    scopus 로고
    • MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2
    • COI: 1:CAS:528:DC%2BD1MXotlWru7w%3D, PID: 19398717
    • Spaggiari, G. M., Abdelrazik, H., Becchetti, F., & Moretta, L. (2009). MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood, 113(26), 6576–6583.
    • (2009) Blood , vol.113 , Issue.26 , pp. 6576-6583
    • Spaggiari, G.M.1    Abdelrazik, H.2    Becchetti, F.3    Moretta, L.4
  • 10
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • COI: 1:CAS:528:DC%2BD2MXhsVGjt7Y%3D, PID: 15494428
    • Aggarwal, S., & Pittenger, M. F. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 105(4), 1815–1822.
    • (2005) Blood , vol.105 , Issue.4 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 11
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • COI: 1:CAS:528:DC%2BD2cXlt1Krt7k%3D, PID: 15001472
    • Meisel, R., Zibert, A., Laryea, M., Gobel, U., Daubener, W., & Dilloo, D. (2004). Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood, 103(12), 4619–4621.
    • (2004) Blood , vol.103 , Issue.12 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Gobel, U.4    Daubener, W.5    Dilloo, D.6
  • 12
    • 84863230136 scopus 로고    scopus 로고
    • Soluble molecules are key in maintaining the immunomodulatory activity of murine mesenchymal stromal cells
    • COI: 1:CAS:528:DC%2BC38XjslKjsLs%3D, PID: 22250196
    • Liu, H., Lu, K., MacAry, P. A., Wong, K. L., Heng, A., Cao, T., et al. (2012). Soluble molecules are key in maintaining the immunomodulatory activity of murine mesenchymal stromal cells. Journal of Cell Science, 125(Pt 1), 200–208.
    • (2012) Journal of Cell Science , vol.125 , pp. 200-208
    • Liu, H.1    Lu, K.2    MacAry, P.A.3    Wong, K.L.4    Heng, A.5    Cao, T.6
  • 13
    • 33846006154 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD2sXivVyrur0%3D, PID: 16985180
    • Sato, K., Ozaki, K., Oh, I., Meguro, A., Hatanaka, K., Nagai, T., et al. (2007). Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood, 109(1), 228–234.
    • (2007) Blood , vol.109 , Issue.1 , pp. 228-234
    • Sato, K.1    Ozaki, K.2    Oh, I.3    Meguro, A.4    Hatanaka, K.5    Nagai, T.6
  • 14
    • 63049103761 scopus 로고    scopus 로고
    • In vitro and in vivo immunosuppressive characteristics of hepatocyte growth factor-modified murine mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD1MXktlKjsLc%3D, PID: 19368120
    • Bian, L., Guo, Z. K., Wang, H. X., Wang, J. S., Wang, H., Li, Q. F., et al. (2009). In vitro and in vivo immunosuppressive characteristics of hepatocyte growth factor-modified murine mesenchymal stem cells. In vivo, 23(1), 21–27.
    • (2009) In vivo , vol.23 , Issue.1 , pp. 21-27
    • Bian, L.1    Guo, Z.K.2    Wang, H.X.3    Wang, J.S.4    Wang, H.5    Li, Q.F.6
  • 15
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: advances in eicosanoid biology
    • COI: 1:CAS:528:DC%2BD3MXovFSqurw%3D, PID: 11729303
    • Funk, C. D. (2001). Prostaglandins and leukotrienes: advances in eicosanoid biology. Science, 294(5548), 1871–1875.
    • (2001) Science , vol.294 , Issue.5548 , pp. 1871-1875
    • Funk, C.D.1
  • 16
    • 33745266737 scopus 로고    scopus 로고
    • Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
    • COI: 1:CAS:528:DC%2BD28XksFymsLw%3D, PID: 16540375
    • Park, J. Y., Pillinger, M. H., & Abramson, S. B. (2006). Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clinical Immunology, 119(3), 229–240.
    • (2006) Clinical Immunology , vol.119 , Issue.3 , pp. 229-240
    • Park, J.Y.1    Pillinger, M.H.2    Abramson, S.B.3
  • 17
    • 84857999388 scopus 로고    scopus 로고
    • Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BC38XjtVOksLY%3D, PID: 22333568
    • Hegyi, B., Kudlik, G., Monostori, E., & Uher, F. (2012). Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells. Biochemical and Biophysical Research Communications, 419(2), 215–220.
    • (2012) Biochemical and Biophysical Research Communications , vol.419 , Issue.2 , pp. 215-220
    • Hegyi, B.1    Kudlik, G.2    Monostori, E.3    Uher, F.4
  • 18
    • 77951975599 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism
    • COI: 1:CAS:528:DC%2BC3cXlvVegur8%3D, PID: 20207200
    • Chen, K., Wang, D., Du, W. T., Han, Z. B., Ren, H., et al. (2010). Human umbilical cord mesenchymal stem cells hUC-MSCs exert immunosuppressive activities through a PGE2-dependent mechanism. Clinical Immunology, 135(3), 448–458.
    • (2010) Clinical Immunology , vol.135 , Issue.3 , pp. 448-458
    • Chen, K.1    Wang, D.2    Du, W.T.3    Han, Z.B.4    Ren, H.5
  • 19
    • 84971325257 scopus 로고    scopus 로고
    • PGE2 maintains self-renewal of human adult stem cells via EP2-mediated autocrine signaling and its production is regulated by cell-to-cell contact
    • COI: 1:CAS:528:DC%2BC28XptVSmsbw%3D, PID: 27230257
    • Lee, B. C., Kim, H. S., Shin, T. H., Kang, I., Lee, J. Y., Kim, J. J., et al. (2016). PGE2 maintains self-renewal of human adult stem cells via EP2-mediated autocrine signaling and its production is regulated by cell-to-cell contact. Scientific Reports, 6, 26298.
    • (2016) Scientific Reports , vol.6 , pp. 26298
    • Lee, B.C.1    Kim, H.S.2    Shin, T.H.3    Kang, I.4    Lee, J.Y.5    Kim, J.J.6
  • 20
    • 84989790738 scopus 로고    scopus 로고
    • Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-gamma-treated mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BC2MXhsFGht73E, PID: 26416211
    • Hermankova, B., Zajicova, A., Javorkova, E., Chudickova, M., Trosan, P., Hajkova, M., et al. (2016). Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-gamma-treated mesenchymal stem cells. Immunobiology, 221(2), 129–136.
    • (2016) Immunobiology , vol.221 , Issue.2 , pp. 129-136
    • Hermankova, B.1    Zajicova, A.2    Javorkova, E.3    Chudickova, M.4    Trosan, P.5    Hajkova, M.6
  • 21
    • 84905472517 scopus 로고    scopus 로고
    • A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging
    • PID: 25090227
    • Yu, K. R., Lee, J. Y., Kim, H. S., Hong, I. S., Choi, S. W., Seo, Y., et al. (2014). A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging. PLoS One, 9(8), e102426.
    • (2014) PLoS One , vol.9 , Issue.8
    • Yu, K.R.1    Lee, J.Y.2    Kim, H.S.3    Hong, I.S.4    Choi, S.W.5    Seo, Y.6
  • 22
    • 77955093536 scopus 로고    scopus 로고
    • Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton’s Jelly and bone marrow sources
    • COI: 1:CAS:528:DC%2BC3cXpsFKqurs%3D, PID: 20619400
    • Najar, M., Raicevic, G., Boufker, H. I., Fayyad Kazan, H., De Bruyn, C., Meuleman, N., et al. (2010). Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue, Wharton’s Jelly and bone marrow sources. Cellular Immunology, 264(2), 171–179.
    • (2010) Cellular Immunology , vol.264 , Issue.2 , pp. 171-179
    • Najar, M.1    Raicevic, G.2    Boufker, H.I.3    Fayyad Kazan, H.4    De Bruyn, C.5    Meuleman, N.6
  • 23
    • 84994304901 scopus 로고    scopus 로고
    • Mesenchymal stem cells improve mouse non-heart-beating liver graft survival by inhibiting Kupffer cell apoptosis via TLR4-ERK1/2-Fas/FasL-caspase3 pathway regulation
    • Tian, Y., Wang, J., Wang, W., Ding, Y., Sun, Z., Zhang, Q., et al. (2016). Mesenchymal stem cells improve mouse non-heart-beating liver graft survival by inhibiting Kupffer cell apoptosis via TLR4-ERK1/2-Fas/FasL-caspase3 pathway regulation. Stem Cell Research & Therapy, 7(1), 157.
    • (2016) Stem Cell Research & Therapy , vol.7 , Issue.1 , pp. 157
    • Tian, Y.1    Wang, J.2    Wang, W.3    Ding, Y.4    Sun, Z.5    Zhang, Q.6
  • 24
    • 22544436066 scopus 로고    scopus 로고
    • Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4 + T cells
    • COI: 1:CAS:528:DC%2BD2MXmtlWjtrc%3D
    • Baratelli, F., Lin, Y., Zhu, L., Yang, S. C., Heuzé-Vourc’h, N., Zeng, G., et al. (2005). Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4 + T cells. Journal of Immunology, 175(3), 1483–1490.
    • (2005) Journal of Immunology , vol.175 , Issue.3 , pp. 1483-1490
    • Baratelli, F.1    Lin, Y.2    Zhu, L.3    Yang, S.C.4    Heuzé-Vourc’h, N.5    Zeng, G.6
  • 25
    • 84862291054 scopus 로고    scopus 로고
    • Safety of mesenchymal stem cells for clinical application
    • PID: 22685475
    • Wang, Y., Han, Z. B., Song, Y. P., & Han, Z. C. (2012). Safety of mesenchymal stem cells for clinical application. Stem Cells International, 2012, 652034.
    • (2012) Stem Cells International , vol.2012 , pp. 652034
    • Wang, Y.1    Han, Z.B.2    Song, Y.P.3    Han, Z.C.4
  • 26
    • 0030861750 scopus 로고    scopus 로고
    • Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines
    • COI: 1:CAS:528:DyaK2sXms1GgsL4%3D, PID: 9376604
    • Hill, G. R., Crawford, J. M., Cooke, K. R., Brinson, Y. S., Pan, L., & Ferrara, J. L. (1997). Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood, 90(8), 3204–3213.
    • (1997) Blood , vol.90 , Issue.8 , pp. 3204-3213
    • Hill, G.R.1    Crawford, J.M.2    Cooke, K.R.3    Brinson, Y.S.4    Pan, L.5    Ferrara, J.L.6
  • 27
    • 84904498956 scopus 로고    scopus 로고
    • The biology of graft-versus-host disease: experimental systems instructing clinical practice
    • COI: 1:CAS:528:DC%2BC2cXht1Cqu7%2FP, PID: 24914137
    • Markey, K. A., MacDonald, K. P., & Hill, G. R. (2014). The biology of graft-versus-host disease: experimental systems instructing clinical practice. Blood, 124(3), 354–362.
    • (2014) Blood , vol.124 , Issue.3 , pp. 354-362
    • Markey, K.A.1    MacDonald, K.P.2    Hill, G.R.3
  • 28
    • 84905197650 scopus 로고    scopus 로고
    • Virus interactions with endothelial cell receptors: implications for viral pathogenesis
    • COI: 1:CAS:528:DC%2BC2cXhtlGgtr%2FK, PID: 25063986
    • Dalrymple, N. A., & Mackow, E. R. (2014). Virus interactions with endothelial cell receptors: implications for viral pathogenesis. Current Opinion in Virology, 7, 134–140.
    • (2014) Current Opinion in Virology , vol.7 , pp. 134-140
    • Dalrymple, N.A.1    Mackow, E.R.2
  • 29
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD28XhtFGht7bJ, PID: 16123384
    • Krampera, M., Cosmi, L., Angeli, R., Pasini, A., Liotta, F., Andreini, A., et al. (2006). Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells, 24(2), 386–398.
    • (2006) Stem Cells , vol.24 , Issue.2 , pp. 386-398
    • Krampera, M.1    Cosmi, L.2    Angeli, R.3    Pasini, A.4    Liotta, F.5    Andreini, A.6
  • 30
    • 84863637920 scopus 로고    scopus 로고
    • Functional heterogeneity of mesenchymal stem cells: implications for cell therapy
    • COI: 1:CAS:528:DC%2BC38XpvFOgtLg%3D, PID: 22511358
    • Phinney, D. G. (2012). Functional heterogeneity of mesenchymal stem cells: implications for cell therapy. Journal of Cellular Biochemistry, 113(9), 2806–2812.
    • (2012) Journal of Cellular Biochemistry , vol.113 , Issue.9 , pp. 2806-2812
    • Phinney, D.G.1
  • 31
    • 84896487062 scopus 로고    scopus 로고
    • Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density
    • Kim, D. S., Lee, M. W., Yoo, K. H., Lee, T. H., Kim, H. J., Jang, I. K., et al. (2014). Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density. PLoS One, 9(1), e83363.
    • (2014) Plos One , vol.9 , Issue.1
    • Kim, D.S.1    Lee, M.W.2    Yoo, K.H.3    Lee, T.H.4    Kim, H.J.5    Jang, I.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.