Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required

British Journal of Cancer

Volumn 117, Issue 12, 2017, Pages 1736-1742

  Staudacher, Alexander H ^a   Brown, Michael P ^a,b,c  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Antibody drug conjugate; Bystander killing; Cathepsin B; Non internalising

Indexed keywords

ANTIBODY DRUG CONJUGATE; BRENTUXIMAB VEDOTIN; CATHEPSIN B; MEMBRANE ANTIGEN; TRASTUZUMAB EMTANSINE; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

ANTINEOPLASTIC ACTIVITY; BYSTANDER EFFECT; CELL KILLING; DISULFIDE BOND; DRUG APPROVAL; DRUG BINDING; DRUG TRANSPORT; FOOD AND DRUG ADMINISTRATION; HUMAN; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; TUMOR MICROENVIRONMENT; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG RELEASE; MOLECULARLY TARGETED THERAPY; NEOPLASM;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BYSTANDER EFFECT; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HUMANS; IMMUNOCONJUGATES; MOLECULAR TARGETED THERAPY; NEOPLASMS;

EID: 85038356456     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2017.367     Document Type: Short Survey

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