The development of immunoconjugates for targeted cancer therapy
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Anetumab ravtansine: A novel mesothelin-Targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect
Golfier, S. et al. Anetumab ravtansine: a novel mesothelin-Targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect. Mol. Cancer Ther. 13, 1537-1548 (2014).
Tai, Y. T. et al. Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma. Blood 123, 3128-3138 (2014).
Novel Phase i dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma
Tannir, N. M. et al. Novel Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma. Invest. New Drugs 32, 1246-1257 (2014).
Efficacy studies of an antibody-drug conjugate PSMA-ADC in patient-derived prostate cancer xenografts
DiPippo, V. A. et al. Efficacy studies of an antibody-drug conjugate PSMA-ADC in patient-derived prostate cancer xenografts. Prostate 75, 303-313 (2015).
SGN-LIV1A: A novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer
Sussman, D. et al. SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer. Mol. Cancer Ther. 13, 2991-3000 (2014).
The CD37-Targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model
Beckwith, K. A. et al. The CD37-Targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. Leukemia 28, 1501-1510 (2014).